| Outcome Measures: |
Primary: Change from baseline in hepatic insulin sensitivity, Baseline, 25 weeks|Change from baseline in peripheral tissue insulin sensitivity, Baseline, 25 weeks|Change from baseline in liver fat content, determined using magnetic resonance spectroscopy (MRS), Baseline, 25 weeks|Change from baseline in insulin secretion rate (ISR) during mixed-meal tolerance test (MMTT), Baseline, 25 weeks|Change from baseline in beta-cell glucose sensitivity, determined as a slope of ISR vs. plasma glucose concentration during MMTT, Baseline, 25 weeks | Secondary: Changes from baseline in substrate oxidation and energy production rates during MMTT and euglycemic clamp, Baseline, 25 weeks|Changes from baseline in insulin clearance during MMTT and euglycemic clamp, Baseline, 25 weeks|Change from baseline in suppression of free fatty acids (FFAs) during euglycemic clamp, Baseline, 25 weeks|Changes from baseline in basal and postprandial plasma glucagon, FFAs and β-hydroxybutyrate during MMTT, Baseline, 25 weeks|Change from baseline in renal threshold for glucose (RTG), estimated using an MMTT-based method, Baseline, 25 weeks
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