| Trial ID: | L6711 |
| Source ID: | NCT00771693
|
| Associated Drug: |
Insulin Aspart (Novorapid®)
|
| Title: |
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
|
| Acronym: |
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes Mellitus|Postprandial Hyperglycemia
|
| Interventions: |
DRUG: Insulin aspart (Novorapid®)
|
| Outcome Measures: |
Primary: To evaluate if platelet activation following a carbohydrate rich meal is related to the post-prandial hyperglycemia, and thus can be attenuated by premeal insulin treatment in patients with T2DM., 90 minutes after the meal|Co- primary platelet response variables: U46619 stimulated platelet P- selectin activation, platelet-leukocyte aggregation, platelet-platelet aggregates and platelet-monocyte aggregates., After completion of the study in 20 patients | Secondary: To elucidate if short-term lowering of blood glucose by insulin infusion (pretreatment standardization of blood glucose) reduces platelet activity in patients with T2DM., After completion of the glucose normalization (before the meal)
|
| Sponsor/Collaborators: |
Sponsor: Karolinska Institutet
|
| Gender: |
ALL
|
| Age: |
CHILD, ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
18
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2007-05
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| Completion Date: |
2011-07
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| Results First Posted: |
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| Last Update Posted: |
2022-05-27
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| Locations: |
Department of Medicine, Clinical pharmacology Unit, Karolinska University Hospital, Solna., Stockholm, SE 171 76, Sweden
|
| URL: |
https://clinicaltrials.gov/show/NCT00771693
|
