| Outcome Measures: |
Primary: Maximum Plasma Concentration (Cmax), 0, 0.5, 2, 3, 4.5 6, 24, and 48 hours post dose|Area Under the Concentration Time Curve From Time Zero to 24 Hours (AUC0-24), 0, 0.5, 2, 3, 4.5, 6, and 24 hours post dose|Area Under the Concentration Time Curve From Time Zero to 48 Hours (AUC0-48), 0, 0.5, 2, 3, 4.5 6, 24, and 48 hours post dose|Area Under the Concentration Time Curve From Time Zero to Infinity (AUC0-∞), 0, 0.5, 2, 3, 4.5, 6, 24, and 48 hours post dose|Volume of Distribution at Steady State (Vss), The theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug, 0, 0.5, 2, 3, 4.5, 6, 24, and 48 hours post dose|Elimination Rate Constant (Ke), 0, 0.5, 2, 3, 4.5, 6, 24, and 48 hours post dose|Total Drug Clearance (CLtotal), The rate at which a drug substance is removed from the body, 0, 0.5, 2, 3, 4.5, 6, 24, and 48 hours post dose|Drug Clearance Due to Dialysis (CLdialysis), The rate at which a drug substance is removed from the body due to dialysis therapy, 0, 0.5, 2, 3, 4.5, 6, 24, and 48 hours post dose |
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