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Clinical Trial Details

Trial ID: L6810
Source ID: NCT00442845
Associated Drug: Atorvastatin (Lipitor)
Title: Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)
Acronym: ACTFAST
Status: COMPLETED
Study Results: NO
Results:
Conditions: Coronary Arteriosclerosis|Diabetes Mellitus, Type 2|Cerebrovascular Accident|Dyslipidemia|Peripheral Vascular Disease
Interventions: DRUG: Atorvastatin (Lipitor)
Outcome Measures: Primary: Proportion of subjects achieving a LDL-C target of < 100 mg/dL (2.6 mmol/L) after 12 weeks. | Secondary: Percentage of subjects achieving:|LDL-C target <100 mg/dL (<2.6 mmol/L) after 6 weeks of treatment.|Total cholesterol (TC)/HDL-C ratio target (<4.0) after 6 and 12 weeks of treatment.|Either the LDL-C <100mg/dL (<2.6 mmol/L) or TC/HDL-C ratio (<4.0) targets after 6 and 12 weeks of treatment.|Both the LDL-C <100mg/dL (<2.6 mmol/L) and TC/HDL-C ratio (<4.0) targets after 6 and 12 weeks of treatment.|LDL-C <100mg/dL (<2.6 mmol/L) or TC/HDL-C ratio (<4.0) targets after 6 and 12 weeks of treatment by LDL-C strata.|LDL-C target (<100 mg/dL) by primary inclusion diagnosis (CHD, CHD-equivalent, diabetes or 10-year CHD risk-equivalent >20%).|The mean percent change in LDL-C, high density lipoprotein cholesterol (HDL-C),TC/HDL-C ratio, non HDL-C (in subjects with triglycerides [TG] ≥200 mg/dL or 2.3 mmol/L), TC and TG from baseline to 6 and 12 weeks of treatment.|Change from baseline in apolipoprotein-B (Apo-B) and change from baseline in glycosylated hemoglobin (HbA1c) was assessed at 12 weeks.
Sponsor/Collaborators: Sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 2080
Study Type: INTERVENTIONAL
Study Designs: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2003-01
Completion Date: 2004-02
Results First Posted:
Last Update Posted: 2021-02-18
Locations: Pfizer Investigational Site, Mississauga, Ontario, Cameroon|Pfizer Investigational Site, Calgary, Alberta, Canada|Pfizer Investigational Site, Edmonton, Alberta, Canada|Pfizer Investigational Site, Medicine Hat, Alberta, Canada|Pfizer Investigational Site, Red Deer, Alberta, Canada|Pfizer Investigational Site, Campbell River, British Columbia, Canada|Pfizer Investigational Site, Maple Ridge, British Columbia, Canada|Pfizer Investigational Site, Nanaimo, British Columbia, Canada|Pfizer Investigational Site, New Westminster, British Columbia, Canada|Pfizer Investigational Site, Richmond, British Columbia, Canada|Pfizer Investigational Site, Surrey, British Columbia, Canada|Pfizer Investigational Site, Vancouver, British Columbia, Canada|Pfizer Investigational Site, Vernon, British Columbia, Canada|Pfizer Investigational Site, Victoria, British Columbia, Canada|Pfizer Investigational Site, Brandon, Manitoba, Canada|Pfizer Investigational Site, Winnipeg, Manitoba, Canada|Pfizer Investigational Site, Ajax, Ontario, Canada|Pfizer Investigational Site, Brampton, Ontario, Canada|Pfizer Investigational Site, Burlington, Ontario, Canada|Pfizer Investigational Site, Cambridge, Ontario, Canada|Pfizer Investigational Site, Cornwall, Ontario, Canada|Pfizer Investigational Site, Etobicoke, Ontario, Canada|Pfizer Investigational Site, Mississauga, Ontario, Canada|Pfizer Investigational Site, Niagara Falls, Ontario, Canada|Pfizer Investigational Site, North York, Ontario, Canada|Pfizer Investigational Site, Orillia, Ontario, Canada|Pfizer Investigational Site, Oshawa, Ontario, Canada|Pfizer Investigational Site, Rexdale, Ontario, Canada|Pfizer Investigational Site, Sarnia, Ontario, Canada|Pfizer Investigational Site, Scarborough, Ontario, Canada|Pfizer Investigational Site, Simcoe, Ontario, Canada|Pfizer Investigational Site, Thunder Bay, Ontario, Canada|Pfizer Investigational Site, Toronto, Ontario, Canada|Pfizer Investigational Site, Weston, Ontario, Canada|Pfizer Investigational Site, Whitby, Ontario, Canada|Pfizer Investigational Site, Willowdale, Ontario, Canada|Pfizer Investigational Site, Chicoutimi, Quebec, Canada|Pfizer Investigational Site, Cowansville, Quebec, Canada|Pfizer Investigational Site, Drummondville, Quebec, Canada|Pfizer Investigational Site, Joliette, Quebec, Canada|Pfizer Investigational Site, Laval, Quebec, Canada|Pfizer Investigational Site, Levis, Quebec, Canada|Pfizer Investigational Site, Maria, Quebec, Canada|Pfizer Investigational Site, Montreal, Quebec, Canada|Pfizer Investigational Site, Newport, Quebec, Canada|Pfizer Investigational Site, Pointe Claire, Quebec, Canada|Pfizer Investigational Site, Repentigny, Quebec, Canada|Pfizer Investigational Site, Saint Hyacinthe, Quebec, Canada|Pfizer Investigational Site, Sainte Foy, Quebec, Canada|Pfizer Investigational Site, Sherbrooke, Quebec, Canada|Pfizer Investigational Site, St-georges (beauce), Quebec, Canada|Pfizer Investigational Site, St. Lambert, Quebec, Canada|Pfizer Investigational Site, Thetford Mines, Quebec, Canada|Pfizer Investigational Site, Vaudreuil, Quebec, Canada|Pfizer Investigational Site, Saskatoon, Saskatchewan, Canada|Pfizer Investigational Site, Quebec, Canada|Pfizer Investigational Site, Tricase, (le), Italy|Pfizer Investigational Site, Vimercate, (mi), Italy|Pfizer Investigational Site, Somma Lombardo, (va), Italy|Pfizer Investigational Site, Asti, Italy|Pfizer Investigational Site, Bari, Italy|Pfizer Investigational Site, Belluno, Italy|Pfizer Investigational Site, Bologna, Italy|Pfizer Investigational Site, Bolzano, Italy|Pfizer Investigational Site, Catania, Italy|Pfizer Investigational Site, Chieti, Italy|Pfizer Investigational Site, Ferrara, Italy|Pfizer Investigational Site, Firenze, Italy|Pfizer Investigational Site, Foggia, Italy|Pfizer Investigational Site, Grosseto, Italy|Pfizer Investigational Site, Napoli, Italy|Pfizer Investigational Site, Novara, Italy|Pfizer Investigational Site, Palermo, Italy|Pfizer Investigational Site, Perugia, Italy|Pfizer Investigational Site, Potenza, Italy|Pfizer Investigational Site, Prato, Italy|Pfizer Investigational Site, Roma, Italy|Pfizer Investigational Site, Salerno, Italy|Pfizer Investigational Site, San Donato Milanese, Italy|Pfizer Investigational Site, Sassari, Italy|Pfizer Investigational Site, Savona, Italy|Pfizer Investigational Site, Siena, Italy|Pfizer Investigational Site, Torino, Italy|Pfizer Investigational Site, Venezia, Italy|Pfizer Investigational Site, Hospitalet de Llobregat, Barcelona, Spain|Pfizer Investigational Site, Girona, Cataluna, Spain|Pfizer Investigational Site, Galdakao, Vizcaya, Spain|Pfizer Investigational Site, Avila, Spain|Pfizer Investigational Site, Barcelona, Spain|Pfizer Investigational Site, Granada, Spain|Pfizer Investigational Site, Huelva, Spain|Pfizer Investigational Site, Jerez de La Frontera, Spain|Pfizer Investigational Site, Madrid, Spain|Pfizer Investigational Site, Marbella, Spain|Pfizer Investigational Site, Sevilla, Spain|Pfizer Investigational Site, Tarragona, Spain|Pfizer Investigational Site, Valencia, Spain|Pfizer Investigational Site, Newtonabbey, Belfast, United Kingdom|Pfizer Investigational Site, Aylesbury, Buckinghamshire, United Kingdom|Pfizer Investigational Site, ELY, Cambs, United Kingdom|Pfizer Investigational Site, Peterborough, Cambs, United Kingdom|Pfizer Investigational Site, Newtonabbey, CO Antrim, United Kingdom|Pfizer Investigational Site, Hastings, EAST Sussex, United Kingdom|Pfizer Investigational Site, High Valleyfield, Fife, United Kingdom|Pfizer Investigational Site, Rutherglen, Glasgow, United Kingdom|Pfizer Investigational Site, Leslie, FIFE, Glenrotheshire, United Kingdom|Pfizer Investigational Site, Sunbury on Thames, Middlesex, United Kingdom|Pfizer Investigational Site, Frome, Somerset, United Kingdom|Pfizer Investigational Site, Barry, South Glamorgan, United Kingdom|Pfizer Investigational Site, Doncaster, South Yorkshire, United Kingdom|Pfizer Investigational Site, Stairfoot, Barnsley, South Yorkshire, United Kingdom|Pfizer Investigational Site, Addlestone, Surrey, United Kingdom|Pfizer Investigational Site, East Horsley, Surrey, United Kingdom|Pfizer Investigational Site, Atherstone, Warks, United Kingdom|Pfizer Investigational Site, Balsall Common, WEST Midlands, United Kingdom|Pfizer Investigational Site, Pound Hill, Crawley, WEST Sussex, United Kingdom|Pfizer Investigational Site, Trowbridge, Wiltshire, United Kingdom|Pfizer Investigational Site, Chippenham, Wilts, United Kingdom|Pfizer Investigational Site, Sheffield, Yorkshire, United Kingdom|Pfizer Investigational Site, Bath, United Kingdom|Pfizer Investigational Site
URL: https://clinicaltrials.gov/show/NCT00442845

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D320 Atorvastatin small molecule DB01076 Details