| Outcome Measures: |
Primary: HbA1c, Change from baseline in HbA1c level (%), baseline and 3, 12, and 24 months after intervention|Body mass index, Change from baseline in body mass index (kg/m\^2), baseline and 3, 12, and 24 months after intervention | Secondary: Estimated glomerular filtration rate, Change from baseline in level of estimated glomerular filtration rate (ml/min/1.73 m\^2), baseline, 12 and 24 months after intervention|HOMA-IR index, Change from baseline in level of HOMA-IR index (Homeostasis Model Assessment of Insulin Resistance) derived from the plasma insulin level (mIU/L) and plasma glucose level (mmol/L) of a participant: \[(plasma insulin level) x (plasma glucose level)\]/22.5, where the value of HOMA-IR index \> 2.0 suggests insulin resistance, baseline, 6 and 12 months after intervention|Urinary creatinine-adjusted excretion of albumin, Change from baseline in level of urinary creatinine-adjusted excretion of albumin in morning spot urine samples (mg/mmol), baseline, 12 and 24 months after intervention|Cardiovascular parameters of PAT and IMT, Change from baseline in peripheral arterial tone by using EndoPAT 2000, the thickness of intima-media complex of carotid arteries (μm), baseline, 6 and 12 months after intervention|LDL cholesterol, Change from baseline in level of LDL cholesterol (mmol/L), baseline, 6 and 12 months after intervention|Triglycerides, Change from baseline in level of triglycerides (mmol/L), baseline, 6 and 12 months after intervention|NT-proBNP, Change from baseline in serum level of NT-proBNP (pmol/L), baseline, 6 and 12 months after intervention|hsCRP, Change from baseline in serum level of hsCRP ( mg/L), baseline, 6 and 12 months after intervention|PAT, Change from baseline in peripheral arterial tone by using EndoPAT 2000 (Ratio is created using the post and pre occlusion values), baseline, 6 and 12 months after intervention|IMT, Change from baseline in the thickness of intima-media complex of carotid arteries (μm), baseline, 6 and 12 months after intervention|LV ejection fraction, Change from baseline in ejection fraction (%) by echocardiography, baseline, 6 and 12 months after intervention|LV mass index, Change from baseline in LV mass index (g/m\^2) by echocardiography, baseline, 6 and 12 months after intervention|GLS by 2D-STE, Change from baseline in global longitudinal strain by 2D Speckle-tracking echocardiography (%), baseline, 6 and 12 months after intervention|Molecular-genetic markers of endothelial damage, Change from baseline in serum level of microRNA-126, microRNA-21, microRNA-27, miRNA-125 and miRoRNA-155 (relative units), baseline, 6 and 12 months after intervention
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