| Outcome Measures: |
Primary: Inflammation assessed by measuring blood levels of inflammatory biomarkers, Investigate the effect of colchicine on the level inflammation blood biomarkers (C- reactive protein -CRP, IL-6, TNF-a) of adult patients on maintenance hemodialysis (MHD), 3 months|Incidence of treatment emergent adverse events as assessed by routine clinical and blood tests monitoring, In each visit (every month) participants will be interview for every change in their clinical status including specific known adverse events of colchicine (such as diarrhea , neuropathy, fever, muscle weakness). moreover, blood tests will be drawn for complete blood count and chemistry. physical examination will be carried out at ehch visit., 3 months | Secondary: Nutritional score- VAS - visual analog scale, - above 48 millimeteres is considered a good score for accessing no feeling of hunger, 3 months|Quality of life score-SF-36- "36 item short form survey", score range 0-100 - higher scores indicate better health status ( score of 50 is a normative value), 3 months|Body composition by bioimpedance-lean body mass, measurement of lean body mass will be described by killograms units, 3 months|NUTRITIONAL SCORE- ADAT- appetite and diet assessment tool, - 1- very good 2-good 3- fair 4- poor 5-very poor, 3 MONTHS|NUTRITIONAL SCORE- OSND- objective score of nutrition on dialysis, normal score 28-32, intermediate malnutrion 24-27, 23 and lower- severe malnutrition, 3 MONTHS|NUTRITIONAL SCORE-SNAQ- simplified nutritional appetite questionnaire - score, - score at or below 14 indicates significant risk of at least 5 % weight loss within 6 months, 3 MONTHS|NUTRITIONAL SCORE-MIS- malnutrition inflammation score, - 0 is normal, 30-severe degree of malnutrition and inflammation, 3 MONTHS|Quality of life score-ESAS- Edmonton Sympthom Assessemnt System, - score between 1-10 . 10 is worsth, 3 months|Quality of life score-EQ-5D - EuroQual-5 D, score between 0-100 , 0 is the worth health status as percieved by the patient, 100 is the best health status as percieved by the patient, 3 months|Body composition by bioimpedance- fat mass, measurement of fat mass will be described by killograms units, 3 months|Body composition by bioimpedance-phase angle, measurement of phase angle will be described by the time difference between adjacent current and voltage peaks, divided by 180 degrees, 3 months
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