| Trial ID: | L0731 |
| Source ID: | NCT01994733
|
| Associated Drug: |
Calcium Carbonate ( Intensive Phosphate Control)
|
| Title: |
Two phosphAte taRGets in End-stage Renal Disease Trial (TARGET)
|
| Acronym: |
TARGET
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
End-stage Renal Disease
|
| Interventions: |
DRUG: Calcium carbonate ( Intensive phosphate control)|DRUG: Calcium carbonate (Liberalized phosphate control)
|
| Outcome Measures: |
Primary: Serum phosphate concentration, 26 weeks | Secondary: Number of patients who successfully achieved target serum P at week 26 based on the arm to which they were randomized, 26 weeks|Treatment compliance as defined by taking the study medication at least 80% of the time, 26 weeks|Number of serious adverse events, 26 weeks|Number of hospitalizations for vascular reasons that are unrelated to dialysis access, 26 weeks|Proportion of patients with a vascular death or non-fatal vascular event, 26 weeks|Proportion of patients developing serum calcium > 2.60 mmol/L, 26 weeks|Number of fractures, 26 weeks|Number of patients developing calcific uremic arteriolopathy (ie, calciphylaxis), 26 weeks|Change in quality-of-life, 26 weeks
|
| Sponsor/Collaborators: |
Sponsor: Unity Health Toronto | Collaborators: Canadian Institutes of Health Research (CIHR)
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE2
|
| Enrollment: |
104
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
|
| Start Date: |
2014-01
|
| Completion Date: |
2015-04
|
| Results First Posted: |
|
| Last Update Posted: |
2015-06-23
|
| Locations: |
Foothills Medical Centre, Calgary, Alberta, T2N 2T9, Canada|Capital District Health Authority, Halifax, Nova Scotia, B3H 1V7, Canada|St. Joseph's Healthcare, Hamilton, Ontario, L8N 4A6, Canada|London Health Sciences Centre, London, Ontario, N6G 2V4, Canada|St. Michael's Hospital, Toronto, Ontario, M5B 1W8, Canada
|
| URL: |
https://clinicaltrials.gov/show/NCT01994733
|
