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Clinical Trial Details

Trial ID: L0750
Source ID: NCT06794996
Associated Drug: Inaxaplin
Title: Phase 2b Open-label Study of Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease
Acronym: AMPLIFIED
Status: RECRUITING
Study Results: NO
Results:
Conditions: Proteinuric Kidney Disease
Interventions: DRUG: Inaxaplin
Outcome Measures: Primary: Percent Change in Urine Albumin-Creatinine Ratio (UACR), Baseline and At Week 13 | Secondary: Safety and Tolerability as Assessed by Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs), From Baseline Up To Week 17
Sponsor/Collaborators: Sponsor: Vertex Pharmaceuticals Incorporated
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE2
Enrollment: 45
Study Type: INTERVENTIONAL
Study Designs: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2025-02-04
Completion Date: 2026-12-30
Results First Posted:
Last Update Posted: 2025-04-22
Locations: South Florida Research Institute, Lauderdale Lakes, Florida, 33313, United States|Renal Associates, LLC, Columbus, Georgia, 31904, United States|Javara Inc./Privia Medical Group Georgia, LLC - Fayetteville, Fayetteville, Georgia, 30214, United States|Georgia Nephrology, Lawrenceville, Georgia, 30046, United States|Javara Inc. /Privia Medical Group Georgia, LLC - Savannah, Savannah, Georgia, 31406, United States|Renal Associates of Baton Rouge, Baton Rouge, Louisiana, 70808, United States|Northwest Louisiana Nephrology, LLC - Shreveport, Shreveport, Louisiana, 71101, United States|Javara Inc./Privia Medical Group, LLC MidAtlantic-Silver Spring, MD, Silver Spring, Maryland, 20901, United States|Nephrology and Hypertension Associates, LTD, Tupelo, Mississippi, 38801, United States|DaVita Clinical Research, Las Vegas, Nevada, 89107, United States|Scott Research, Inc., Laurelton, New York, 11413, United States|North Carolina Nephrology P.A. - Cary Office, Cary, North Carolina, 27511, United States|Columbia Nephrology Associates, PA, Columbia, South Carolina, 29203, United States|Carolina Nephrology, PA, Spartanburg, South Carolina, 29306, United States|Dallas Renal Group - 2, Dallas, Texas, 75230, United States|Dallas Renal Group - 1, Dallas, Texas, 75237, United States|Dallas Nephrology Associates - Dallas Landry Office, Dallas, Texas, 75246, United States|Prolato Clinical Research Center, Houston, Texas, 77054, United States|Tks Research, P.L.L.C., Norfolk, Virginia, 23504, United States
URL: https://clinicaltrials.gov/show/NCT06794996

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress