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Clinical Trial Details

Trial ID: L0803
Source ID: NCT00221845
Associated Drug: Ace Inhibition
Title: Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
Acronym: ESCAPE
Status: COMPLETED
Study Results: NO
Results:
Conditions: Children|Chronic Renal Failure|Hypertension|Acquired Kidney Disease|Congenital Kidney Disease
Interventions: DRUG: ACE Inhibition|DRUG: Intensified Blood Pressure Control|DRUG: Add-on Angiotensin Receptor Blockade
Outcome Measures: Primary: Time interval to renal 'loss' as defined by an absolute decrease in creatinine clearance by 50 % or attainment of renal replacement therapy., two-monthly | Secondary: Effect of treatment on urinary protein excretion, two-monthly|Effect of treatment on blood pressure, two-monthly|Safety of treatment, initially weekly, than two-monthly
Sponsor/Collaborators: Sponsor: Heidelberg University | Collaborators: European Commission|Boehringer Ingelheim|Baxter Healthcare Corporation|Aventis Pharmaceuticals
Gender: ALL
Age: CHILD, ADULT
Phases: PHASE3
Enrollment: 400
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 1998-01
Completion Date: 2010-01
Results First Posted:
Last Update Posted: 2010-01-12
Locations: University Hospital Motol, 1st Department of Pediatrics, Prague, 150 18, Czech Republic|Hopital Necker, Division of Pediatric Nephrology, Paris, 75015, France|Inserm U574, Paris, 75015, France|Hopiteaux Universitaires de Strasbourg, Strasbourg, 67098, France|Humboldt University Berlin, Charité Children's Hospital, Department of Pediatric Nephrology, Berlin, 13353, Germany|University Hospital Essen, Department of Pediatrics, Pediatric Nephrology Unit, Essen, 45122, Germany|University Hospital Hamburg-Eppendorf, University Children's Hospital, Dept. of Pediatric Nephrology, Hamburg, 20246, Germany|Hannover Medical School, Children's Hospital Div. II, Pediatric Nephrology, Hannover, 30623, Germany|Division of Pediatric Nephrology, Children's Hospital, University of Heidelberg, Heidelberg, 69120, Germany|Urban Hospital St. Georg, Department of Pediatrics, Pediatric Nephrology Unit, Leipzig, 04129, Germany|Johannes Gutenberg University Mainz, Department of Pediatrics,, Mainz, 55131, Germany|Philipps University Marburg, Dept. of Pediatrics, Marburg, 35037, Germany|University Children's Hospital, Dept. of Nephrology, Rostock, 18050, Germany|Semmelweis University Budapest, 1st Department of Pediatrics, Budapest, 1083, Hungary|G.Gaslini Institute, Nephrology Unit, Genoa, 16148, Italy|Azienda Ospedaliera, Istitui Clinici di Perfezionamento, Servizio die Emodialisi Pediatrica, Milano, 20122, Italy|Azienda Ospedaliera die Padova. U.O. Nefrologia Dialisi e Trapianto - Dipartimento di Pediatria, Padova, 35128, Italy|Ospedale Pediatrico Bambino Gesù, Division of Nephrology and Dialysis, Rome, 00165, Italy|Ospedale Infantile Regina Margherita, U.O.A. Nefrologia, Dialisi, Trapianto, Torino, 10126, Italy|Vilnius University Children's Hospital, Pediatric Department, Nephrology Unit, Vilnius, 2600, Lithuania|Jagellonian University Medical College, Department of Pediatric Nephrology, Cracow, 30-663, Poland|Medical University of Gdansk, Pediatric Nephrology Department, Gdansk, 80-211, Poland|Clinic of Pediatrics, Pomeranian Academy of Medicine, Szczecin, 71-344, Poland|Children's Memorial Health Hospital, Nephrology and Kidney Transplantation Department, Warsaw, 04-736, Poland|Hospital S. Joao-Faculade de Medicina do Porto, Dept. of Pediatrics, Porto, 4202 - 451, Portugal|Faculty of Medicine Belgrade, University Children's Hospital, Nephrology Unit, Belgrade, 11000, Serbia|Karolinska Institute, Huddinge University Hospital, Dept. of Pediatrics, Stockholm, 14186, Sweden|University Children's Hospital, Nephrology Unit, Zürich, 8032, Switzerland|Cukurova University School of Medicine, Dept. of Pediatric Nephrology, Adana, 01330, Turkey|Hacettepe University, Faculty of Medicine, Pediatric Nephrology and Rheumatology, Ankara, 06100, Turkey|Istanbul University, Cerrahpasa Medical Faculty, Dept, of Pediatrics, Istanbul, 34303, Turkey|University of Istanbul, Istanbul Medical Faculty, Dept. of Pediatrics, Istanbul, 34390, Turkey|Ege University Medical Faculty, Dept. of Pediatric Nephrology, Izmir, 35100, Turkey
URL: https://clinicaltrials.gov/show/NCT00221845

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress