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Clinical Trial Details

Trial ID: L0866
Source ID: NCT05021835
Associated Drug: Ziltivekimab B
Title: ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
Acronym: ZEUS
Status: ACTIVE_NOT_RECRUITING
Study Results: NO
Results:
Conditions: Cardiovascular Risk|Chronic Kidney Disease|Inflammation
Interventions: DRUG: Ziltivekimab B|DRUG: Ziltivekimab C|DRUG: Placebo (Ziltivekimab B)|DRUG: Placebo (Ziltivekimab C)
Outcome Measures: Primary: Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke, Months, From randomisation (month 0) to end-of-study (up to 48 months) | Secondary: Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation, Months, From randomisation (month 0) to end-of-study (up to 48 months)|Number of heart failure hospitalisations or urgent heart failure visits or CV deaths, Count, From randomisation (month 0) to end-of-study (up to 48 months)|Time to first occurrence of a composite kidney endpoint consisting of: CV death, onset of persistent atleast 40 percent (%) reduction in eGFR (CKD-epidemiology collaboration [CKD-EPI]) compared with baseline, kidney failure, Months, From randomisation (month 0) to end-of-study (up to 48 months)|Time to occurrence of all-cause mortality, Months, From randomisation (month 0) to end-of-study (up to 48 months)|Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint., Months, From randomisation (month 0) to end-of-study (up to 48 months).|Time to first occurrence of MI (fatal and non-fatal)., Months, From randomisation (month 0) to end-of-study (up to 48 months).|Time to first occurrence of stroke (fatal and non-fatal)., Months, From randomisation (month 0) to end-of-study (up to 48 months).|Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke, Months, From randomisation (month 0) to end-of-study (up to 48 months).|Time to first occurrence of a 4-component kidney endpoint consisting of: onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure, Months, From randomisation (month 0) to end-of-study (up to 48 months).|Time to first occurrence of coronary revascularisation, Months, From randomisation (month 0) to end-of-study (up to 48 months).|Change in Urinary Abumin-to-Ceatinine ratio (UACR)., Percentage, From randomisation (month 0) to 2 years (24 months).|Change in eGFR (CKD-EPI)), mL/min/1.73 m\^2, From randomisation (month 0) to 2 years (24 months)|Annual rate of change in eGFR (CKD-EPI) (total eGFR slope), mL/min/1.73 m\^2/ year, From randomisation (month 0) to end-of-study (up to 48 months).|Change in high-sensitivity C-reactive protein (hs-CRP), Percentage, From randomisation (month 0) to 2 years (24 months|Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP), Percentage, From randomisation (month 0) to 2 years (24 months)|Change in left ventricular ejection fraction (LVEF), Percentage, From randomisation (month 0) to 2 years (24 months)|Number of events of atrial fibrillation, Count, From randomisation (month 0) to end-of-study (up to 48 months).|Change in haemoglobin, Grams per deciliter (g/dL), From randomisation (month 0) to 2 years (24 months)|Number of hospitalisations with infection as primary cause or death due to infection., Count, From randomisation (month 0) to end-of-study (up to 48 months).|Change in Short Form 36 (SF-36) Physical Component Score (PCS), Score on scale, From randomisation (month 0) to 2 years (24 months)
Sponsor/Collaborators: Sponsor: Novo Nordisk A/S
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE3
Enrollment: 6200
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Start Date: 2021-08-30
Completion Date: 2026-10-21
Results First Posted:
Last Update Posted: 2025-04-10
Locations: Uni of Alabama at Birmingham, Birmingham, Alabama, 35294, United States|Healthscan Clinical Trials,LLC., Montgomery, Alabama, 36106, United States|Aventiv Research Inc., Mesa, Arizona, 85206, United States|Unity Health-Searcy Medical Center, Searcy, Arkansas, 72143, United States|National Heart Institute Cal, Beverly Hills, California, 90211, United States|Valley Clinical Trials, Covina, California, 91723, United States|Valiance Clinical Research, Huntington Park, California, 90250, United States|Balboa Nephro Med Gr Inc LaMes, La Mesa, California, 91942, United States|First Valley Medical Group, Lancaster, California, 93534, United States|VA Loma Linda Hlthcr Sys, Loma Linda, California, 92357, United States|Pacific Clinical Studies, Los Alamitos, California, 90720, United States|Angel City Research, Inc., Los Angeles, California, 90010, United States|North America Research Institute, Lynwood, California, 90262, United States|Hoag Medical Group, Newport Beach, California, 92663, United States|Valley Clinical Trials, Inc., Northridge, California, 91325, United States|Desert Oasis Hlthcr Med Group, Palm Springs, California, 92262, United States|Riverside Nephrology Physicians, Riverside, California, 92503, United States|N America Res Inst - San Dimas, San Dimas, California, 91773, United States|Lundquist Inst-Biomed Innovtn, Torrance, California, 90502, United States|Bridgeport Hospital, Bridgeport, Connecticut, 06610, United States|VA-Connecticut (VACHS), West Haven, Connecticut, 06516, United States|George Washington Uni Med, Washington, District of Columbia, 20037, United States|Excel Med Ctr Clinical Trials, Boca Raton, Florida, 33434, United States|Innovative Research of W FL, Clearwater, Florida, 33756, United States|Florida Premier Cardiology, Delray Beach, Florida, 33445, United States|Integrative Research Assoc Inc, Fort Lauderdale, Florida, 33312, United States|Encore Medical Research LLC, Hollywood, Florida, 33021, United States|Est Cst Inst for Rsrch,Jksnvil, Jacksonville, Florida, 32216, United States|Baptist Heart Specialists, Jacksonville, Florida, 32258, United States|San Marcus Res Clin Miami Lakes, Miami Lakes, Florida, 33014, United States|Life Spring Research, Miami, Florida, 33130, United States|Office of Kenneth Blaze DO, Miramar, Florida, 33027, United States|Suncoast Clinical Research, Inc., Palm Harbor, Florida, 34684, United States|Hanson Clinical Research Center, Port Charlotte, Florida, 33952, United States|St Johns Center for Clin. Res, Saint Augustine, Florida, 32086, United States|Clinical Research of Cent FL, Winter Haven, Florida, 33880, United States|Javara/Privia Med Grp GA,LLC, Albany, Georgia, 31707, United States|Southeastern Clinical R.I., Augusta, Georgia, 30904, United States|Southeastern Clinical Research Institute, LLC, Augusta, Georgia, 30904, United States|Hope Clin Res & Wellness, Conyers, Georgia, 30094, United States|Javara Inc._Albany, Fayetteville, Georgia, 30214, United States|NSC Research, Inc, Johns Creek, Georgia, 30024, United States|Javara Inc._Winston Salem, Savannah, Georgia, 31406, United States|Saltzer Medical Group Research, Nampa, Idaho, 83686-6011, United States|Northwest Heart Clin. Res., Arlington Heights, Illinois, 60005, United States|Research by Design LLC, Chicago, Illinois, 60643, United States|Clinical Invest Special_Gurnee, Gurnee, Illinois, 60031, United States|Chicago Medical Research LLC, Hazel Crest, Illinois, 60429, United States|Endeavor Health, Skokie, Illinois, 60077, United States|Central Illinois Diabetes and Clinical Research, Springfield, Illinois, 62711, United States|MediSphere Medical RC, Evansville, Indiana, 47714, United States|Velocity Clin. Res Valparaiso, Valparaiso, Indiana, 46383, United States|Midwest Heart & Vasc Spec, Overland Park, Kansas, 66211, United States|Cotton O'Neil Clin Research Ctr, Topeka, Kansas, 66606, United States|The Research Group of Lexington LLC, Lexington, Kentucky, 40503, United States|Grace Research, LLC, Bossier City, Louisiana, 71111, United States|Clinical Trials of Ame, LLC, Monroe, Louisiana, 71201, United States|IMA Clinical Research, Monroe, Louisiana, 71201, United States|Grace Research, LLC_Shreveport, Shreveport, Louisiana, 71105, United States|Louisiana Heart Center_Slidell, Slidell, Louisiana, 70458, United States|John P Hakim MD and Associates, Clinton, Maryland, 20735, United States|Brigham & Women's Hospital, Boston, Massachusetts, 02115-5804, United States|Pentucket Medical Associates, Haverhill, Massachusetts, 01830, United States|Henry Ford Hospital_Detroit, Detroit, Michigan, 48202, United States|Elite Research Center, Flint, Michigan, 48532, United States|Healthy Heart Cardiology, Grand Rapids, Michigan, 49546, United States|McLaren Northern MI Hosp, Petoskey, Michigan, 49770, United States|AHS dba Abbot NW Hosp Diab Cen, Minneapolis, Minnesota, 55407, United States|Clinical Research Consultants, LLC, Kansas City, Missouri, 64111, United States|Gateway CV Research Cntr Inc., Saint Louis, Missouri, 63128, United States|St Louis Heart & Vascular, P.C., Saint Louis, Missouri, 63136, United States|Nebraska Heart Institute_Lincoln, Lincoln, Nebraska, 68526, United States|VA NEB - Western IA Health Stm, Omaha, Nebraska, 68105, United States|Univ of Nebraska Medical CTR, Omaha, Nebraska, 68198-3020, United States|University of Nevada School of Medicine, Las Vegas, Nevada, 89102, United States|Palm Research Center Inc-Vegas, Las Vegas, Nevada, 89128, United States|Advanced Heart Care LLC, Bridgewater, New Jersey, 08807-3064, United States|Uni of New Mexico-Clinical, Albuquerque, New Mexico, 87106, United States|NYU Nephrology Associates, Mineola, New York, 11501, United States|NYU Grossman School of Med, New York, New York, 10016, United States|Mount Sinai Hosp at NYC, New York, New York, 10019, United States|Mattoo & Bhat M.A., Ridgewood, New York, 11385, United States|Saratoga Clinical Research, Saratoga Springs, New York, 12866, United States|Southgate Medical Group, LLP, West Seneca, New York, 14224, United States|Great Lakes Medical Research, Westfield, New York, 14787, United States|Mountain Kidney & Hypertension Associates, Asheville, North Carolina, 28801, United States|UNC- Chapel Hill, Chapel Hill, North Carolina, 27599, United States|Metrolina Nephrology Associates, PA, Charlotte, North Carolina, 28208, United States|PharmQuest Life Sciences LLC, Greensboro, North Carolina, 27408, United States|Physicians East Endocrinology, Greenville, North Carolina, 27834, United States|Carteret Medical Group, Morehead City, North Carolina, 28557, United States|Lillestol Research LLC, Fargo, North Dakota, 58104, United States|Univ of Cincinnati Med Cent, Cincinnati, Ohio, 45219, United States|VA Northeast Ohio Healthcare System (VANEOHS), Cleveland, Ohio, 44106, United States|Advanced Med Res Maumee, Maumee, Ohio, 43537, United States|Northeast Clinical Research Center, Bethlehem, Pennsylvania, 18017, United States|Aria Endocrine Metabolic Assoc, Philadelphia, Pennsylvania, 19114, United States|Piedmont Research Partners, LLC, Fort Mill, South Carolina, 29707, United States|Palmetto Clinical Research, Greenville, South Carolina, 29615, United States|Univ Diab & Endo Consultants, Chattanooga, Tennessee, 37411, United States|Balad Hlth Sys-Welmont CardCVA, Greeneville, Tennessee, 37745, United States|Tennova HC Turkey Creek MC, Knoxville, Tennessee, 37934, United States|Clinical Neuroscience Solutions, Memphis, Tennessee, 38119, United States|CV Research of Knoxville, Powell, Tennessee, 37849, United States|Liberty Research Center, Arlington, Texas, 76002, United States|Novel Research LLC, Bellaire, Texas, 77401, United States|Osvaldo A. Brusco MD PA, Corpus Christi, Texas, 78414, United States|Thyroid Endocrinology & Diabetes PA, Dallas, Texas, 75208, United States|Liberty Research Center_Dallas, Dallas, Texas, 75230, United States|Renal Disease Research Institute, Dallas, Texas, 75235, United States|Academy of Diabetes, T&E, El Paso, Texas, 79935, United States|Care United Research, LLC, Forney, Texas, 75126, United States|Diabetes and Thyroid Ctr of FW, Fort Worth, Texas, 76132, United States|Javara /TX.Hlth LLC dba Prvia, Fort Worth, Texas, 76133, United States|PrimeCare Medical Group, Houston, Texas, 77024, United States|Baylor College Of Medicine_Houston, Houston, Texas, 77030, United States|Biopharma Informatic_Houston, Houston, Texas, 77043, United States|Prolato Clinical Research Center, Houston, Texas, 77054, United States|Prolato Clinical Research Cntr, Houston, Texas, 77054, United States|Card Specialists of Willowbrook, Houston, Texas, 77070, United States|PlanIt Research, PLLC, Houston, Texas, 77079, United States|Biopharma Informatic, LLC, Houston, Texas, 77084, United States|DCOL Ctr for Clin Res, Longview, Texas, 75605, United States|Texas Inst, Kdny & Endo Disor, Lufkin, Texas, 75904, United States|RGV Endocrine Center, McAllen, Texas, 78503, United States|Texas Diabetes Institute, San Antonio, Texas, 78207-5209, United States|Clinical Advancement Ctr, PLLC, San Antonio, Texas, 78212, United States|Sun Research Institute, San Antonio, Texas, 78215, United States|VIP Trials, San Antonio, Texas, 78230, United States|NE Clin Res of San Antonio, San Antonio, Texas, 78233, United States|Javara Privia Grp Gulf Cst LLC, San Marcos, Texas, 78666, United States|Simcare Medical Research, LLC, Sugar Land, Texas, 77478, United States|York Clinical Research LLC, Norfolk, Virginia, 23504, United States|Virginia Commonwealth University Health System, Richmond, Virginia, 23298, United States|VA Medical Center_Salem, Salem, Virginia, 24153-6404, United States|Selma Medical Associates, Winchester, Virginia, 22601-3834, United States|Providence Medical Research Center, Spokane, Washington, 99204, United States|Aspirus Research Institute, Wausau, Wisconsin, 54401, United States|Mautalen Salud e investigación, Caba, Buenos Aires, C1128 AAF, Argentina|Sanatorio Finochietto, Caba, Buenos Aires, C1213, Argentina|Instituto Cardiovascular Buenos Aires, Caba, Buenos Aires, C1428ART, Argentina|CEMEDIC, Caba, Buenos Aires, C1440CFD, Argentina|Hospital Italiano de la Plata, La Plata, Buenos Aires, B 1900AXI, Argentina|Centro de Investigaciones Médicas Clínica de Fracturas y Or, Mar del Plata, Buenos Aires, B7600GNY, Argentina|Centro Medico Lebensohn, Buenos Aires, B6000BHA, Argentina|Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli, Buenos Aires, C1425AGC, Argentina|Cardiología Palermo, Ciudad Autónoma de Buenos Aire, 1425, Argentina|Instituto Médico DAMIC, Córdoba, X5003DCE, Argentina|Instituto Médico CER, Quilmes - Buenos Aires, B1878DVB, Argentina|Investigaciones Clinicas Tucuman, San Miguel De Tucumán, Tucumán., T4000, Argentina|Instituto de Investigaciones Clinicas San Nicolás, San Nicolás, B2900, Argentina|The Canberra Hospital_Garran, Garran, Australian Capital Territory, 2605, Australia|Gosford Renal Research, Gosford, New South Wales, 2250, Australia|St George Hospital, Kogarah, New South Wales, 2217, Australia|Westmead Applied Research Centre, Westmead, New South Wales, 2145, Australia|Illawarra Heart Health Centre, Wollongong, New South Wales, 2500, Australia|Core Research Centre, Milton, Queensland, 4064, Australia|Nightingale Research, Adelaide, South Australia, 5000, Australia|Royal Adelaide Hospital Cardiovascular Clinical Trials, Adelaide, South Australia, 5000, Australia|HeartCare SA, Leabrook, South Australia, 5068, Australia|Monash Health Heart, Clayton, Victoria, 3168, Australia|St Vincent's Hospital_Fitzroy_0, Fitzroy, Victoria, 3065, Australia|Geelong Cardiology Research Unit, Geelong, Victoria, 3220, Australia|Melbourne Renal Research Group, Reservoir, Victoria, 3073, Australia|Sunshine Hospital, St Albans, Victoria, 3021, Australia|La Trobe Regional Hospital, Traralagon, Victoria, 3844, Australia|HeartCare WA (Joondalup), Joondalup, Western Australia, 6027, Australia|Algemeen Stedelijk Ziekenhuis - Aalst - Interventional Cardiology, Aalst, 9300, Belgium|Imeldaziekenhuis - Bonheiden - Department of Endocrinology, Bonheiden, 2820, Belgium|AZ Klina - Brasschaat - Cardiology, Brasschaat, 2930, Belgium|AZ Sint-Jan - Campus Brugge_Brugge, Brugge, 8000, Belgium|AZ Sint-Jan - Campus Brugge, Brugge, 8000, Belgium|Ziekenhuis Oost Limburg - Cardiology, Genk, 3600, Belgium|Ziekenhuis Oost-Limburg AV - Cardiology, Genk, 3600, Belgium|AZ Groeninge - Kortrijk - Cardiology, Kortrijk, 8500, Belgium|CHR de la Citadelle, Liège, 4000, Belgium|AZ Sint-Maarten Mechelen - Cardiology, Mechelen, 2800, Belgium|AZ OOSTENDE (Campus DAMIAAN), Oostende, 8400, Belgium|Hospital do Coração do Brasil, Brasilia, Distrito Federal, 70390-700, Brazil|Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo, Vitória, Espirito Santo, 29055-450, Brazil|Hospital Felicio Rocho, Belo Horizonte, Minas Gerais, 30110-934, Brazil|Eurolatino Medical Research Center, Uberlândia, Minas Gerais, 38400-500, Brazil|Instituto Pró-Renal Brasil, Curitiba, Parana, 80440-020, Brazil|Núcleo de Pesquisa Clínica S/S, Curitiba, Parana, 80730-150, Brazil|AngioCor Blumenau, Blumenau, Santa Catarina, 89020-430, Brazil|Instituto de Pesquisa Clínica de Campinas, Campinas, Sao Paulo, 13060-080, Brazil|PUCCAMP - Hospital e Maternidade Celso Pierro, Campinas, Sao Paulo, 13060-803, Brazil|i9 Pesquisas Clínicas, Campinas, Sao Paulo, 13092-133, Brazil|CIP Centro Integrado de Pesquisas do Hospital de Base, São José do Rio Preto, Sao Paulo, 15090-000, Brazil|CPQuali Pesquisa Clínica Ltda, São Paulo, Sao Paulo, 01228-000, Brazil|Instituto do Coração - HCFMUSP, São Paulo, Sao Paulo, 05403-000, Brazil|Impar Serviços Hospitalares S/A, São Paulo, SP, 01409-902, Brazil|Integral Pesquisa e Ensino, Cidade Nova Votuporanga, São Paulo, 15501-405, Brazil|Praxis Pesquisa Médica, Santo André, São Paulo, 09090-790, Brazil|Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre/ RS, 90035-074, Brazil|HBA S/A Assistência Médica e Hospitalar, Salvador, 41810-011, Brazil|CEMEC - Centro Multidisciplinar de Estudos Clínicos, São Bernardo Do Campo/SP, 09715-090, Brazil|Centro de Diabetes e Obesidade - HRim e Hipertensao, São Paulo - SP, 04038-002, Brazil|Medical Centre Diamedical-2013, Dimitrovgrad, 6400, Bulgaria|'Medical center Medi city 21' OOD, Kyustendil, 2500, Bulgaria|SHACT Sveti Georgi - Pernik, Pernik, 2300, Bulgaria|"Medical center Medconsult Pleven" OOD, Pleven, 5800, Bulgaria|MHAT Heart and Brain, Pleven, 5804, Bulgaria|"UMHAT "Sveti Georgi" EAD, Plovdiv, 4002, Bulgaria|'MHAT Hadzhi Dimitar' OOD, Sliven, 8800, Bulgaria|Mhat "Nch", Sofia, 1309, Bulgaria|"Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic, Sofia, 1407, Bulgaria|"Diagnostic - Consulting Center Aleksandrovska" EOOD, Sofia, 1431, Bulgaria|UMHAT "Sveti Ivan Rilski", Sofia, 1431, Bulgaria|"Medical Center Hera" EOOD - Sofia, Sofia, 1510, Bulgaria|Medical center ISUL - Tsaritsa Yoanna EOOD, Sofia, 1527, Bulgaria|"UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology, Sofia, 1750, Bulgaria|"UMHAT "Sveta Anna" Sofia", Sofia, 1750, Bulgaria|"Prevencia-2000-MCOC", Stara Zagora, 6000, Bulgaria|Medical Center "Nov Rehabilitatsionen center" EOOD, Stara Zagora, 6001, Bulgaria|UMHAT "Sveta Marina" EAD, Varna, 9010, Bulgaria|Medical center Berbatov, Yambol, 8600, Bulgaria|LMC Clin Res Inc. Calgary, Calgary, Alberta, T2H 2G4, Canada|C-endo Diab Endo Clin Calgery, Calgary, Alberta, T2V 4J2, Canada|Synergy Wellness Clinic, Sherwood Park, Alberta, T8H 0N2, Canada|BC Diabetes Canada, Vancouver, British Columbia, V5Y 3W2, Canada|Nova Scotia Hlth Halifax, Halifax, Nova Scotia, B3H 2Y9, Canada|LMC Diabetes & Endocrinology (Barrie), Barrie, Ontario, L4N 7L3, Canada|LMC ClinRsrh Inc.Brampton, Brampton, Ontario, L6S 0C6, Canada|LMC Clin Res Inc. Thornhill, Concord, Ontario, L4K 4M2, Canada|Centricity Research Etobicoke, Etobicoke, Ontario, M9R 4E1, Canada|Premier Clinical Trial Research Network (PCTRN), Hamilton, Ontario, L8L 5G4, Canada|LMC Research Inc. Ottawa, Nepean, Ontario, K2J 0V2, Canada|Partnrs Adv Cardio Eval (PACE), Newmarket, Ontario, L3Y 2P6, Canada|North York Diagn & Cardiac Ctr, North York, Ontario, M6B 3H7, Canada|LMC Clinical Research Inc. Oakville, Oakville, Ontario, L6M 1M1, Canada|Kawartha Cardiology Clinical Trials, Peterborough, Ontario, K9J 0B2, Canada|Heart Health Institute Research, Inc., Scarborough, Ontario, M1B 4Z8, Canada|Diabetes Heart Research Centre, Toronto, Ontario, M6G 1M2, Canada|Clinical Research Solutions Inc., Waterloo, Ontario, N2T 0C1, Canada|Viacar Recherche Clinique Inc., Brossard, Quebec, J4Z-2K9, Canada|Ctr de rech Clin de Laval, Laval, Quebec, H7T 2P5, Canada|Centre de recherché du CHUS, Sherbrooke, Quebec, J1H 5N4, Canada|Centre de santé et de services, Terrebonne, Quebec, J6V 2H2, Canada|Recherche Clinique Sigma inc, Quebec, G1G 3Y8, Canada|Institut universitaire de cardiologie, Quebec, G1V 4G5, Canada|CHU de Quebec-Universite Laval, Quebec, G1V4G2, Canada|The Second Hospital of Anhui Medical University, Hefei, Anhui, 230601, China|Beijing Anzhen Hospital, Capital Medical University, Beijing, Beijing, 100029, China|Peking University First Hospital-Cardiology, Beijing, Beijing, 100034, China|Peking University First Hospital, Beijing, Beijing, 100034, China|Xuanwu Hospital Capital Medical University-Cardiology, Beijing, Beijing, 100053, China|Peking University Third Hospital-Cardiology, Beijing, Beijing, 100191, China|Beijing Hospital_Beijing, Beijing, Beijing, 100730, China|Chinses PLA General Hospital-Nephrology, Beijing, Beijing, 100853, China|The Second Affiliated Hospital of Chongqing Medical Univerisity-Cardiology, Chongqing, Chongqing, 402260, China|Lanzhou University Second Hospital_Internal Medicine-Cardiovascular Dept, Lanzhou, Gansu, 730030, China|Shenzhen People's Hospital, Shenzhen, Guangdong, 518020, China|The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China|Wuhan Union Hospital-Cardiology, Wuhan, Hubei, 430022, China|Tongji Hospital, Tongji Medical College of HUST-Cardiology, Wuhan, Hubei, 430030, China|Tongji Hospital, Tongji Medical College of HUST-Nephrology, Wuhan, Hubei, 430030, China|Renmin Hospital of Wuhan University-Cardiology, Wuhan, Hubei, 430060, China|Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China|Changzhou No.2 People's Hospital, Changzhou, Jiangsu, 213003, China|The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, China|The First Affiliated Hospital of Soochow University-Cardiology, Suzhou, Jiangsu, 215006, China|The Affiliated Hospital of Xuzhou Medical University-Cardiology, Xuzhou, Jiangsu, 221002, China|The Affiliated Hospital Of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China|The Affiliated Hospital of Jiangsu University-Nephrology, Zhenjiang, Jiangsu, 212001, China|The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China|Jiangxi Provincial People's Hospital-Cardiology, Nanchang, Jiangxi, 330006, China|The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China|China-Japan Union Hospital of Jilin University-Cardiology, Changchun, Jilin, 130033, China|China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China|The Second Hospital of Jilin University-Nephrology, Changchun, Jilin, 130033, China|The Second Hospital of Jilin University_Changchun, Changchun, Jilin, 130033, China|The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, China|The First Affiliated Hospital of Jinzhou Medical University-Cardiology, Jinzhou, Liaoning, 121012, China|The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)-Cardiology, Jinan, Shandong, 250013, China|Huashan Hospital Fudan University, Shanghai, Shanghai, 200040, China|Shanghai General Hospital-Cardiology, Shanghai, Shanghai, 200080, China|Xinhua Hospital Affiliated To Shanghai Jiao Tong University-Nephrology, Shanghai, Shanghai, 200092, China|Linfen Central Hospital-Cardiology, Linfen, Shanxi, 041099, China|Tianjin People's Hospital, Tianjin, Tianjin, 300122, China|Tianjin 4th Center Hospital, Tianjin, Tianjin, 300140, China|Zhejiang Provincial People's Hospital-Cardiology Department, Hangzhou, Zhejiang, 310014, China|Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, China|Chinese Academy of Medical Sciences Fuwai Hospital, Beijing, 100037, China|Xuanwu Hospital Capital Medical University-Cardiology, Beijing, 100053, China|The First People's Hospital of Changde City -Internal Medicine-Cardiovascular, Changde, 415003, China|The First People's Hospital of Changzhou, Changzhou, 213004, China|Sichuan Provincial People's Hospital- Nephrology, Chengdu, 610071, China|Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Cardiology Department, Dalian, 116033, China|Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Nephrology Department, Dalian, 116033, China|Fu Yang People's Hospital-Nephrology, Fu Yang, 236000, China|Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China|The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology, Hangzhou, 310003, China|Xingtai People's Hospital-Nephrology, Hebei/Xingtai, 054031, China|The Second People's Hospital of Huai'an - Nephrology, Huai'an, 223022, China|Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept, Huizhou, 516001, China|Jinan Central Hospital Affiliated to Shandong University (Cardiovascular Dept), Jinan, 250013, China|The Second Hospital of Shandong University, Jinan, 250033, China|The Second Affiliated Hospital of Kunming Medical University, Kun Ming, 650033, China|The First Affiliated Hospital of Henan University of Science and Technology-Nephrology, Luoyang, 471003, China|The People's Hospital of Guangxi Zhuang Autonomous Region-Cardiology Department, Nanning, 530016, China|The People's Hospital of Guangxi Zhuang Autonomous Region-Nephrology Department, Nanning, 530016, China|The Second Affiliated Hospital of Shantou University Medical College-Nephrology, Shantou, 515065, China|Shengjing Hospital of China Medical University-Cardiology, Shenyang, 110136, China|Shengjing Hospital of China Medical University, Shenyang, 110136, China|The First Affiliated Hospital of Xi'an Jiaotong University-Cardiovascular, Xi'an, 710061, China|The Third Affiliated Hospital Of Xinxiang Medical University-Cardiology, Xinxiang, 453000, China|Clinical Hospital Dubrava, Zagreb, Grad Zagreb, 10000, Croatia|Poliklinika Solmed, Zagreb, Grad Zagreb, 10000, Croatia|Specijalna bolnica Krapinske Toplice - Kardiologija, Krapinske Toplice, Krapinsko Zagorska County, 49217, Croatia|KBC Rijeka, Zavod za kardiomiopatije, Rijeka, 51000, Croatia|KBC Rijeka, Zavod za nefrologiju, Rijeka, 51000, Croatia|KBC Zagreb, Klinika za bolesti srca i krvnih zila, Zagreb, 10000, Croatia|KBC Zagreb, Zavod za nefrologiju, Zagreb, 10000, Croatia|Edumed Broumov, Broumov, 550 01, Czechia|KARDIOLOGIE - LIBEREC s.r.o., Liberec, 460 02, Czechia|EDUMED s.r.o. Nachod, Náchod, 547 01, Czechia|IKEM Klinika nefrologie, Praha 4, 140 21, Czechia|Medicon a.s., Praha, 170 00, Czechia|Nemocnice Slany Kardiologie, Slany, 274 01, Czechia|Aalborg Universitetshospital Kardiologisk Afdeling, Aalborg, 9000, Denmark|Aarhus Universitetshospital, Hjertesygdomme, Aarhus N, 8200, Denmark|Regionshospitalet Gødstrup, Hjertesygdomme, Herning, 7400, Denmark|Hvidovre Hospital Hjertemedicinsk, Hvidovre, 2650, Denmark|Kolding Sygehus Karkirurgi, Kolding, 6000, Denmark|Sjællands Universitetshospital_Roskilde, Roskilde, 4000, Denmark|Kardiologisk Odense & Svendborg, Svendborg, 5700, Denmark|Medical Center - University Of Freiburg, Freiburg, Baden-Württemberg, 79106, Germany|SRH Klinikum Karlsbad - Langensteinbach GmbH - Innere Medizin, Karlsbad, Baden-Württemberg, 76307, Germany|RED-Institut für medizinische Forschung und Fortbildung GmbH, Oldenburg in Holstein, Holstein, 23758, Germany|REGIOMED Klinikum Sonneberg/Neuhaus - Innere Medizin, Sonneberg, Thüringen, 96515, Germany|Universitaetsklinikum Aachen - Medizinische Klinik 1, Aachen, 52074, Germany|Universitaetsklinikum Aachen AöR, Aachen, 52074, Germany|Praxis Dr.med. Frank Menzel, Dessau, 06846, Germany|Kreutzmann, Dresden, 01277, Germany|Herzzentrum Dresden GmbH Universitaetsklinik, Dresden, 01307, Germany|Herzzentrum Dresden GmbH Universitätsklinik, Dresden, 01307, Germany|DaVita Clinical Research Deutschland GmbH, Düsseldorf, 40210, Germany|Zentrum fuer klinische Studien Suedbrandenburg GmbH, Elsterwerda, 04910, Germany|InnoDiab Forschung GmbH, Essen, 45136, Germany|Zentrum für klinische Forschung, Dr. med. Lüdemann, Falkensee, 14612, Germany|MVZ CCB Frankfurt Und Main-Taunus GbR, Frankfurt, 60389, Germany|Nephrologie Universitätsklinikum Frankfurt, Frankfurt, 60590, Germany|Studienzentrum ClinPhenomics, Frankfurt, 60596, Germany|UKS - Innere Medizin III, Homburg, 66421, Germany|University Hospital Jena KöR, Jena, 07747, Germany|Universitätsklinikum Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck, Lübeck, 23538, Germany|Universitätsmedizin Mainz, Kardiologie I, Studienzentrum, Mainz, 55131, Germany|Praxis Reichelsheim, Reichelsheim, 61203, Germany|Kahrmann, Witten, 58455, Germany|University Hospital of Athens ATTIKON, Athens, Attica, 12462, Greece|University Hospital of Athens ATTIKON, Haidari-Athens, Attica, GR-12462, Greece|Alexandroupoli University General Hospital, Alexandroupoli, 68100, Greece|"Laiko" General Hospital of Athens, Athens, 11527, Greece|"Sotiria" Thoracic Diseases Hospital of Athens, Athens, 11527, Greece|Hippokration Hospital, Athens, 11527, Greece|Alexandra General Hospital, Therapeutic Clinic, Athens, 11528, Greece|Konstantopouleio G.H. of Athens, "Agia Olga", Athens, 14233, Greece|"Hygeia" General Hospital of Athens, Athens, 15123, Greece|Iatriko Athinon (Athens Medical Canter), Athens, 15125, Greece|Iatriko Athinon 'Palaiou Falirou', Athens, 17562, Greece|Konstantopouleio G.H. of Athens, "Agia Olga", Athens, GR-14233, Greece|"Hygeia" General Hospital of Athens, Athens, GR-15123, Greece|Iatriko Athinon 'Palaiou Falirou', Athens, GR-17562, Greece|General Hospital of Chios "Skilitsio", Chios, 82100, Greece|General Hospital of Chios "Skilitsio", Chios, GR82100, Greece|Periphery University Hospital of Heraklion, Heraklion, 71500, Greece|University General Hospital of Ioannina,Internal Medicine, Ioannina, 45500, Greece|KAT General Hospital of Attica, Kifissia, GR-14561, Greece|General Hospital of Lamia, Lamia, 35100, Greece|Univ Gen Hospital Larisa, Cardiology Medicine Clinic, Larissa, 41110, Greece|Univ Gen Hospital Larisa, Cardiology Medicine Clinic, Larissa, GR-41110, Greece|Iatriko Athinon (Athens Medical Canter), Pylea, Thessaloniki, 57001, Greece|General University Hospital of Patras,Nephrology clinic, Rio, Patra, 26504, Greece|"AHEPA" University General Hospital of Thessaloniki, Thessaloniki, 54636, Greece|"AHEPA" University Hospital of Thessaloniki, Thessaloniki, 54636, Greece|General Hospital of Thessaloniki "Ippokrateio", Thessaloniki, 54642, Greece|General Hospital of Thessaloniki 'Ippokrateio' Dialysis Unit, Thessaloniki, 54642, Greece|General Hospital of Thessaloniki 'Agios Pavlos', Thessaloniki, 55134, Greece|"Thermi" Private Hosital, Thessaloniki, 57001, Greece|Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt, Thessaloniki, 57010, Greece|"Thermi" Private Hosital, Thessaloniki, GR-57001, Greece|Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés, Békéscsaba, Békés Megye, 5600, Hungary|Selye János Kórház, Komárom, Komárom-Esztergom, 2921, Hungary|Léda Platán Magánklinika, Zalaegerszeg, Zala Megye, 8900, Hungary|EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság, Baja, 6500, Hungary|Tagore Medical Center, Balatonfüred, 8230, Hungary|Gottsegen György Országos Kardiológiai Intézet, Budapest, 1096, Hungary|Jahn Ferenc Dél-pesti Kórház és Rendelőintézet, Budapest, 1204, Hungary|DE KK Kardiológiai és Szívsebészeti klinika, Debrecen, 4032, Hungary|Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ, Szeged, 6725, Hungary|Lalitha Super Specialities Hospital, Guntur, Andhra Pradesh, 522001, India|Vedanta Hospitals, Guntur, Andhra Pradesh, 522001, India|NIZAM'S Institute of Medical Sciences, Hyderabad, Andhra Pradesh, 500082, India|Sunrise Hospital, Vijayawada, Andhra Pradesh, 520002, India|G B Pant Institute of Postgraduate Medical Education and Research, New Delhi, Delhi, 110002, India|Batra Hospital and Medical Research Center, New Delhi, Delhi, 110062, India|Apollo CHSF Heart Institute, Ahmedabad, Gujarat, 380059, India|Shri B. D. Mehta Mahavir Heart Institute, Surat, Gujarat, 395001, India|Unicare heart institute and research centre, Surat, Gujarat, 395001, India|BAPS Pramukh Swami Hospital, Surat, Gujarat, 395009, India|Lifecare Hospital and Research Centre, Bangalore, Karnataka, 560092, India|Sri Jayadeva Institute of Cardiovascular Sciences & Research, Bengaluru, Karnataka, 560069, India|Omega Hospital (P) Limited, Mangalore, Karnataka, 575002, India|Kasturba Medical College and Hospital, Manipal, Manipal, Karnataka, 576104, India|Kasturba Medical College and Hospital, Manipal, Karnataka, 576104, India|KLES & Prabhakar Kore Hospital and Research Centre, Belgaum, Karnatka, 590010, India|Lisie Hospital, Kochi, Kerala, 682018, India|Calicut Medical College, Kozhikode, Kerala, 673008, India|Government Medical College Trivandrum, Trivandrum, Kerala, 695011, India|Kamalnayan Bajaj Hospital, Aurangabad, Maharashtra, 431005, India|Kamalnayan Bajaj Hospital, Aurangabad, Maharashtra, 431010, India|Seth GS medical college and KEM Hospital, Mumbai, Maharashtra, 400012, India|Government Medical College and Super Speciality Hospital, Nagpur, Nagpur, Maharashtra, 440003, India|Arneja Heart & Multispeciality Hospital, Nagpur, Maharashtra, 440010, India|Shri Krishna Hrudayalaya & Critical Care Centre, Nagpur, Maharashtra, 440012, India|Chopda Medicare and Research Centre Pvt. Ltd., Nashik, Maharashtra, 422005, India|Vijan Hospital & Research Centre, Nashik, Maharashtra, 422005, India|B J Goverment Medical College and Sassoon General Hospital, Pune, Maharashtra, 411001, India|VMMC & Safdarjung Hospital, New Dehli, New Delhi, 110029, India|Dayanand Medical College & Hospital, Ludhiana, Punjab, 141001, India|Apollo Hospitals Education & Research Foundation, Chennai, Tamil Nadu, 600006, India|Osmania General Hospital, Hyderabad, Telangana, 500012, India|Guru Nanak CARE Hospitals, Hyderabad, Telangana, 500020, India|Osmania General Hospital_Hyderabad, Hyderabad, Telengana, 500012, India|Apollo Hospital Jubilee Hills, Hyderabad, Hyderabad, Telengana, 500033, India|Osmania General Hospital, Hyderbad, Telengana, 500 012, India|Gandhi Memorial Hospital- King George's Medical University, Lucknow, Uttar Pradesh, 226003, India|Medanta Lucknow Hospital, Lucknow, Uttar Pradesh, 226030, India|Eternal Heart Care Centre, Jaipur, 302017, India|G B Pant Institute of Postgraduate Medical Education and Res, New Delhi, 110002, India|Lok Nayak Hospital, New Delhi, 110002, India|Max Super Speciality Hospital, Saket, New Delhi, 110017, India|Max Super Speciality Hospital_New Delhi, New Delhi, 110017, India|Fortis Escort Health Institute, New Delhi, 110025, India|Sir Ganga Ram Hospital, New Delhi, 110060, India|Lakshmi Hospital, Palakkad, 678013, India|Diabetes Clinic Wolfson MC, Holon, 58100, Israel|Hadassah Ein Kerem MC - Cardio, Jerusalem, 91120, Israel|Cardiology department, Western Galilee Medical Center, Nahariya, 22100, Israel|Belinson hospital, Rabin medical center, Petach Tikva, 49100, Israel|Kaplan Medical Center_Rehovot, Rehovot, 7661041, Israel|Cardio Vascular Research Center Sourasky MC, Tel Aviv, 6423906, Israel|Sheba Medica Center - Clinical Research Unit, Tel Hashomer, 5265601, Israel|Azienda Ospedaliero-Universitaria Renato Dulbecco, Catanzaro, Cz, 88100, Italy|A.O.U. Ferrara, Sant'Anna, Cona (Ferrara), Fe, 44124, Italy|ASST Papa Giovanni XXIII, Bergamo, Lombardia, 24127, Italy|Policlinico S. Orsola - Malpighi, Bologna, 40138, Italy|Università degli studi G. D'Annunzio Chieti Pescara - CAST, Chieti Scalo, 66100, Italy|AOU Careggi Firenze, Firenze, 50134, Italy|IRCCS Azienda Ospedaliero Universitaria San Martino - IST, Genova, 16132, Italy|Centro Cardiologico Monzino. Istituto di Ricovero e Cura, Milano, 20138, Italy|ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari, Montichiari, 25018, Italy|Azienda Ospedaliera Universitaria Federico II di Napoli, Napoli, 80131, Italy|AOUP Giaccone Palermo, Palermo, 90127, Italy|ARNAS Ospedali Civico Di Cristina Benfratelli, Palermo, 90127, Italy|Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy|AOU Pisana Cisanello, Pisa, 56124, Italy|Policlinico Tor Vergata, Roma, 00133, Italy|Policlinico A. Gemelli IRCCS, Roma, 00168, Italy|AOU S. Andrea, Rome, 00189, Italy|Azienda Sanitaria Univ Giuliano Isontina, Trieste, 34128, Italy|AOUI Verona, Verona, 37126, Italy|Uwajima City Hospital_ Cardiology, Uwajima-shi, Ehime, 798-8510, Japan|Seino Internal Medicine Clinic, Koriyama-shi, Fukushima, Japan, 963-8851, Japan|Jinnouchi Hospital, Kumamoto-shi, Kumamoto, Japan, 862-0976, Japan|Miyazaki Medical Association Hospital, Miyazaki-shi, Miyazaki, 880-2102, Japan|NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine, Bunkyo-ku, Tokyo, 113-8603, Japan|The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine, Bunkyo-ku, Tokyo, 113-8655, Japan|Akaicho Clinic, Chiba-shi, Chiba, 260-0804, Japan|Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine, Chikushino-shi, Fukuoka, 818-8516, Japan|University of Yamanashi Hospital_Cardiology, Chuo-city, Yamanashi, 409-3898, Japan|Saiseikai Fukuoka General Hospital, Fukuoka-shi, Fukuoka, 810-0001, Japan|Fukuoka University Hospital_Cardiology, Fukuoka-shi, Fukuoka, 814-0133, Japan|National Hospital Organization Kyushu Medical Center, Fukuoka-shi, 810-8563, Japan|JA Shizuoka Kohseiren Enshu Hospital_ cardiology, Hamamatsu-shi, Shizuoka, 430-0929, Japan|Nishiyamado Keiwa Hospital, Ibaraki,, 331-0133, Japan|Naka Kinen Clinic, Ibaraki, 311-0113, Japan|National Hospital Organization Mito Medical Center_Cardiovascular medicine, Ibaraki, 311-3193, Japan|Kishiwada Tokushukai Hospital, Kishiwada, Osaka, 596-0042, Japan|North Alps Medical Center Azumi Hospital, Kita-azumi-gun, Nagano, 399-8695, Japan|National Hospital Organization Fukuokahigashi Medical Center, Koga-shi, Fukuoka, 811-3195, Japan|Kumamoto University Hospital, Cardiovascular Medicine, Kumamoto-shi, Kumamoto, 860-8556, Japan|NHO Kure Medical Center and Chugoku Cancer Center, Kure-shi, Hiroshima, 737-0023, Japan|Kyoto Okamoto Memorial Hospital, Kusegun, Kyoto, 613-0034, Japan|Rakuwakai Otowa Hospital, Kyoto-shi, Kyoto, 607-8062, Japan|National Hospital Organization Kyoto Medical Center_Cardiology, Kyoto-shi, Kyoto, 612-8555, Japan|Ijinkai Takeda General Hospital, Cardiovascular Medicine, Kyoto-shi,Kyoto, 601-1495, Japan|Maebashi Red Cross Hospital, Maebashi-shi, Gunma, 371-0811, Japan|Matsubara Tokushukai Hospital, Matsubara-shi, Osaka, 580-0032, Japan|Chiba-Nishi General Hospital, Cardiology, Matsudo-shi, 270-2251, Japan|Shinshu University Hospital_Matsumoto-shi, Nagano, Matsumoto-shi, Nagano, 390-8621, Japan|Mishuku Hospital_Meguro-ku, Tokyo, Meguro-ku, Tokyo, 153-0051, Japan|Tokyo Saiseikai Central Hospital, Minato-ku, Tokyo, 108-0073, Japan|Hayama Heart Center, Miura-gun, Kanagawa, 240-0116, Japan|Miyakonojo Medical Association Hospital, Miyakonojo-shi, Miyazaki, 885-0002, Japan|Iwate Prefectural Central Hospital, Morioka-shi, Iwate, 020-0066, Japan|Social Medical Corporation Kojunkai Daido Clinic, Nagoya-shi, Aichi, 457-0818, Japan|Nagoya University Hospital_Nagoya-shi, Aichi, Nagoya-shi, Aichi, 466-8560, Japan|Naha City Hospital, Naha-shi, Okinawa, 902-8511, Japan|Nara Prefecture General Medical Center, Nara-shi, Nara, 630-8581, Japan|Hyogo Prefectural Nishinomiya Hospital, Nishinomiya-shi, Hyogo, 662-0918, Japan|Oita Medical Center_Cardiology, Oita-shi, Oita, 870-0263, Japan|Kawasaki Medical School Hospital, Okayama, 701-0192, Japan|Omihachiman Community Medical Center_Omihachiman-shi, Siga, Omihachiman-shi, Siga, 523-0082, Japan|Sakurabashi Watanabe Advanced Healthcare Hospital, Osaka-city, Osaka, 530-0005, Japan|Yodogawa Christian Hospital, Osaka-shi, Osaka, 533-0024, Japan|Osaka City General Hospital_Osaka-shi, Osaka, Osaka-shi, Osaka, 534-0021, Japan|Kitada Clinic, Osaka-shi, Osaka, 538-0044, Japan|Social Corporation Keigakukai Minami Osaka Hospital, Osaka-shi,Osaka, 559-0012, Japan|Saiseikai Suita Hospital_Cardiovascular Medicine, Osaka, 564-0013, Japan|Takatsuki Red Cross Hospital, Osaka, 569-1045, Japan|Yao Tokushukai General Hospital, Osaka, 581-0011, Japan|Ota Memorial Hospital, Ota-shi, Gunma, 373-8585, Japan|Kitasato University Hospital_Sagamihara-shi, Kanagawa, Sagamihara-shi, Kanagawa, 252-0375, Japan|National Hospital Organization Sagamihara National Hospital, Sagamihara-shi, Kanagawa, 252-0392, Japan|Sanai Hospital, Saitama-shi, Saitama, 338-0837, Japan|Hanaoka Seishu Memorial Hospital, Sapporo-shi, Hokkaido, 062-0003, Japan|Tohoku University Hospital, Cardiovascular, Sendai-shi, Miyagi, 980-8574, Japan|Sendai Cardiovascular Center_Cardiology, Sendai-shi, Miyagi, 981-3133, Japan|Shinden Higashi Clinic, Sendai-shi, Miyagi, 983-0039, Japan|Saiseikai Suita Hospital_Suita-shi, Osaka, Suita-shi, Osaka, 564-0013, Japan|Osaka Saiseikai Senri Hospital, Suita-shi, Osaka, 565-0862, Japan|Takamatsu Red Cross Hospital_Cardiovascular Medicine, Takamatsu-shi, Kagawa, 760-0017, Japan|Kagawa Prefectural Central Hospital, Cardiovascular Medicine, Takamatsu-shi, Kagawa, 760-8557, Japan|Minamino Cardiovascular Hospital, Tokyo, 192-0918, Japan|Saiseikai tondabayashi Hospital, Tondabayashi-shi, Osaka, 584-0082, Japan|Tsukuba Medical Center Hospital_Department of Cardiology, Tsukuba-shi, Ibaraki, 305-8558, Japan|Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology, Wakayama, 640-8558, Japan|National Hospital Organization Saitama Hospital, Wako-shi, Saitama, 351-0102, Japan|Saiseikai Yokohamashi Nanbu Hospital_Cardiology, Yokohama-shi, Kanagawa, 234-0054, Japan|Yokohama City University Hospital, Yokohama-shi, Kanagawa, 236-0004, Japan|Sanyudo Hospital, Yonezawa-shi, Yamagata, 992-0033, Japan|Dong-A University Medical Center, Busan, 49201, Korea, Republic of|Daegu Catholic Univ. Medical Center, Daegu, 42472, Korea, Republic of|Keimyung University Dongsan Medical Center, Daegu, 42601, Korea, Republic of|Chungnam National University Hospital, Daejeon, 35015, Korea, Republic of|Wonju Severance Christian Hospital, Gangwon-do, 26426, Korea, Republic of|National Health Insurance Corporation Ilsan Hospital, Goyang, 410-719, Korea, Republic of|Chonnam National University Hospital, Gwangju, 61469, Korea, Republic of|Seoul National University Bundang Hospital, Gyeonggi-do, 13620, Korea, Republic of|Hallym University Sacred Heart Hospital, Gyeonggi-Do, 14068, Korea, Republic of|Hanyang University GURI Hospital, Gyeonggi-do, 471-101, Korea, Republic of|Gachon University Gil Medical Center, Incheon, 21565, Korea, Republic of|Nowon Eulji Medical Center, Eulji University, Seoul, 01830, Korea, Republic of|Kyunghee University Medical Center, Seoul, 02447, Korea, Republic of|Korea University Anam Hospital, Seoul, 02841, Korea, Republic of|Seoul National University Hospital, Seoul, 03080, Korea, Republic of|Severance Hospital, Yonsei University Health System, Seoul, 03722, Korea, Republic of|Konkuk University Medical Center, Seoul, 05030, Korea, Republic of|Gangdong Kyung Hee University Hospital, Seoul, 05278, Korea, Republic of|Seoul Saint Mary's Hospital, Seoul, 06591, Korea, Republic of|KangNam Sacred Heart Hospital, Seoul, 07441, Korea, Republic of|Korea University Guro Hospital, Seoul, 08308, Korea, Republic of|Ari Med, Daugavpils, 5401, Latvia|Daugavpils Regional Hospital, Daugavpils, 5417, Latvia|Zemgales diabetes centre, Jelgava, 3001, Latvia|P. Stradins Clinical University Hospital, Riga, 1002, Latvia|Adoria, Riga, 1011, Latvia|Riga East Clinical University Hospital - Clinic "Gailezers", Riga, 1079, Latvia|Klinikiniai sprendimai, Alytus, Alytus, 63200, Lithuania|Klinikiniai sprendimai, Alytus, Alytus, LT-63200, Lithuania|Kaunas City Polyclinic, Silainiu department, Kaunas, 48259, Lithuania|Klinikiniai sprendimai, Kaunas, Kaunas, 49387, Lithuania|JSC "Saules seimos medicinos centras", Kaunas, 49449, Lithuania|Hospital of Lithuanian University of Health Sciences Kauno klinikos, Kaunas, 50161, Lithuania|Klinikiniai sprendimai, Kaunas, Kaunas, LT-49387, Lithuania|Kaunas City polyclinic Dainava Branch, Kaunas, LT-51270, Lithuania|Klaipeda university hospital, Klaipeda, 92288, Lithuania|Klaipeda university hospital, Klaipeda, LT-92288, Lithuania|Republican Panevezys Hospital, Panevezys, 35144, Lithuania|Republican Panevezys Hospital, Panevezys, LT-35144, Lithuania|Pirmoji Viltis, Siauliai, LT-76206, Lithuania|JSC Inlita Santaros, Vilnius, 08406, Lithuania|Hospital Sultanah Bahiyah, Alor Setar, Kedah, 05460, Malaysia|Hospital Sultan Abdul Halim, Sungai Petani, Kedah, 08000, Malaysia|Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, 15586, Malaysia|Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan, Kota Bharu, Kelantan, 16150, Malaysia|Hospital Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, 56000, Malaysia|Hospital Seri Manjung, Seri Manjung, Perak, 32040, Malaysia|Sarawak Heart Centre, Kota Samarahan, Sarawak, 94300, Malaysia|University Technology MARA (UiTM) - Sg Buloh, Sungai Buloh, Selangor, 47000, Malaysia|University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, 59100, Malaysia|Hospital Raja Permaisuri Bainun Ipoh, Ipoh, Perak, 30450, Malaysia|National Heart Institute, Kuala Lumpur, 50400, Malaysia|Hospital Seberang Jaya, Pulau Pinang, 13700, Malaysia|Hospital Queen Elizabeth II, Sabah, 88300, Malaysia|Hospital Miri, Sarawak, 98000, Malaysia|Hospital Tuanku Jaafar, Seremban, 70300, Malaysia|Consultorio Privado, Guadalajara, Jalisco, 44657, Mexico|Centro de Investigacion Clinica Endocrinologica de Jalisco, Guadalajara, Jalisco, 44670, Mexico|Clínicos Asociados BOCM, S.C., Mexico City, México, D.F., 03300, Mexico|Cardiolink Clin Trials S.C., Monterrey, Nuevo Leon, 64060, Mexico|Internal Medicine Clin Trials, Monterrey, Nuevo León, 64020, Mexico|Unidad Biomedica Avanzada Monterrey, Monterrey, Nuevo León, 64460, Mexico|Centro de atención e investigación cardiovascular del Potosí, San Luis Potosí, San Luis Potosi, 78200, Mexico|Hospital Angeles de Culiacan, Culiacan, Sinaloa, 80020, Mexico|Centro para el Desarrollo de la Medicina y la Asistencia, Culiacán, Sinaloa, 80230, Mexico|Centro de Investigación Cardiometabólica de Aguascalientes, Aguascalientes, 20230, Mexico|Centro de Estudios Clínicos de Querétaro S.C., Queretaro, 76000, Mexico|FAICIC S. de R.L. de C.V., Veracruz, 91900, Mexico|Noordwest Ziekenhuisgroep, Alkmaar, 1815 JD, Netherlands|Ziekenhuis Groep Twente Almelo, Almelo, 7609 PP, Netherlands|Academisch Medisch Centrum, Amsterdam, 1105 AZ, Netherlands|Gelre Ziekenhuizen Apeldoorn, Apeldoorn, 7334 DZ, Netherlands|Amphia Ziekenhuis, Breda, 4818 CK, Netherlands|St Jansdal, Harderwijk, 3844 DG, Netherlands|Tergooi, locatie Hilversum, Hilversum, 1212 VG, Netherlands|Tergooi, locatie Hilversum, Hilversum, 1213 XZ, Netherlands|Bravis Ziekenhuis, Roosendaal, 4708 AE, Netherlands|Ikazia Ziekenhuis, Rotterdam, 3083 AN, Netherlands|D & A Research B.V., Sneek, 8601 ZR, Netherlands|Zaans Medisch Centrum, Zaandam, 1502 DV, Netherlands|4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu, Wroclaw, Dolnoslaskie, 50-981, Poland|Zdrowie S.C. Agnieszka I Donald Drożdż, Wroclaw, Dolnoslaskie, 51-134, Poland|Kardio Life, Włocławek, Kujawsko-pomorskie, 87-800, Poland|Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Łodzi, Lodz, Lodzkie, 90-549, Poland|NZOZ "CenterMed Lublin" Sp. z o.o., Lublin, Lubelskie, 20-044, Poland|ETG Poniatowa, Poniatowa, Lublin Province, 24-320, Poland|Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski, Gorzow Wielkopolski, Lubuskie, 66-400, Poland|Malopolskie Centrum Sercowo-Naczyniowe, Chrzanow, Malopolskie, 32-500, Poland|Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET, Krakow, Malopolskie, 31-261, Poland|Kresmed Sp. z o. o., Bialystok, Podlaskie, 15-481, Poland|Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio, Bialystok, Podlaskie, 15-540, Poland|Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman, Gdynia, Pomorskie, 81-157, Poland|Aka-Med Centrum, Ruda Slaska, Silesian Voivodeship, 41-710, Poland|Poradnia Aka-Med Centrum Sp. z o.o., Ruda Slaska, Silesian Voivodeship, 41-710, Poland|Centrum Kliniczno Badawcze, Elblag, 82-300, Poland|Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II, Grodzisk Mazowiecki, 05-825, Poland|Specjalistyczna Praktyka Lekarska L. Bryniarski, Krakow, 30-082, Poland|Krakowski Szpital Specjalistyczny im. Jana Pawła II, Kraków, 31-202, Poland|Praktyka Lekarska Mateusz Sidor, Kraków, 31-261, Poland|Centrum Terapii Wspolczesnej, Lodz, 90-338, Poland|Centrum Terapii Współczesnej J.M. Jasnorzewska S.K.A., Lodz, 90-338, Poland|Salve Medica, Lodz, 91-211, Poland|Instytut Centrum Zdrowia Matki Polki, Lodz, 93-338, Poland|Uniwersytecki Szpital Kliniczny W Poznaniu, Poznan, 61-848, Poland|Velocity Nova Sp. z o.o., Pulawy, 24-100, Poland|CENTRUM MEDYCZNE VITA Praktyka Kardiologiczna, Szczecin, 70-341, Poland|Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach, Tychy, 43-100, Poland|NBR Polska Tomasz Klodawski, Warszawa, 00-710, Poland|Narodowy Instytut Kardiologii Klin. Kard. i Ang., Warszawa, 04-628, Poland|Narodowy Instytut Kardiologii Klin. Kard. i Transp., Warszawa, 04-628, Poland|Szpital Powiatowy Im. Hrabiego Stanislawa Lubienskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej W Wegrowie, Wegrow, 07-100, Poland|Centrum Badan Klinicznych, Wroclaw, 51-162, Poland|Velocity Zamość, Zamosc, 22-400, Poland|Unidade Local De Saude De Lisboa Ocidental E.P.E. - Hospital de Santa Cruz, Carnaxide, Lisboa, 2790-134, Portugal|Unidade Local De Saude De Matosinhos E.P.E., Senhora Da Hora, Matosinhos, Matosinhos, 4464-513, Portugal|Unidade Local De Saude De Almada-Seixal E.P.E., Almada, 2805-267, Portugal|Unidade Local De Saude Da Regiao De Aveiro E.P.E., Aveiro, 3814-501, Portugal|Hospital de Braga, Braga, 4710-243, Portugal|Unidade Local de Saúde de Coimbra, E.P.E., Coimbra, 3000-561, Portugal|Unidade Local De Saude de Tâmega e Sousa E.P.E., Guilhufe - Penafiel, 4560-136, Portugal|APDP - Associação Protectora dos Diabéticos de Portugal, Lisboa, 1250-230, Portugal|Unidade Local De Saude De Santa Maria E.P.E., Lisboa, 1649-035, Portugal|Unidade Local De Saude De Lisboa Ocidental E.P.E. - Hospital São Francisco Xavier, Lisbon, 1449-005, Portugal|Unidade Local de Saude de Sao Joao E.P.E, Porto, 4200-319, Portugal|Unidade Local de Saúde da Arrábida, E.P.E., Setubal, 2910-446, Portugal|Unidade Local de Saúde do Alto Minho E.P.E. - Viana do Castelo, Viana do Castelo, 4904-858, Portugal|Unidade Local De Saude De Gaia/Espinho E.P.E., Vila Nova de Gaia, 4434-502, Portugal|Clinic of Diabetes Cluj, Cluj Napoca, Cluj, 400006, Romania|Cabinet Medical de Cardiologie Dr. Calin Pop, Baia Mare, 430222, Romania|Spitalul Județean de Urgență Brăila, Braila, 810325, Romania|Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed, Brasov, 500283, Romania|Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila, Bucharest, 020475, Romania|Davius Clinicmed Srl, Bucharest, 021875, Romania|Hightech Medical Services S.R.L., Bucuresti, 011053, Romania|Spitalul Universitar de Urgență Elias, Bucuresti, 011461, Romania|Lotus Med SRL, Bucuresti, 012292, Romania|Centrul Medical Emerald, Bucuresti, 014146, Romania|Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti, Bucuresti, 042122, Romania|Spitalul Universitar de Urgenta Bucuresti, Bucuresti, 050098, Romania|Mat Cord Biomedica S.R.L., Buzau, 120133, Romania|Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta, Constanta, 900591, Romania|Neurocord Medical SRL, Craiova, 200383, Romania|Cardiomed SRL, Craiova, 200513, Romania|SC Diamed Obesity SRL, Galati, 800291, Romania|Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu", Iasi, 700503, Romania|SC Consultmed SRL, Iasi, 700547, Romania|Spitalul Clinic Judetean De Urgenta Bihor, Oradea, 410469, Romania|Bella Praxis S.R.L., Pascani, 705200, Romania|Sc Sal Med Srl, Pitesti, 110424, Romania|Spitalul Clinic Judetean de Urgenta Targu Mures, Targu Mures, 540136, Romania|Spitalul Clinic Municipal de Urgenta Timisoara, Timisoara, 300254, Romania|Institutul de Boli Cardiovasculare Timisoara, Timisoara, 300310, Romania|CMI Dr. Cristian Podoleanu, Tirgu Mures, 540143, Romania|RBSHI "Altay Regional Cardiology Dispensary", Barnaul, 656055, Russian Federation|Road Clinical Hospital at station Chelyabinsk, Chelyabinsk, 454048, Russian Federation|Irkutsk State Medical Academy of Postgraduate Education, Irkutsk, 664049, Russian Federation|FSB EI "Kazan' State Medical University", Kazan, 420029, Russian Federation|Pirogov Russian National Research Medical University MoH, Moscow, 129226, Russian Federation|Friendship University of Russia MCCH base, Moscow, 129327, Russian Federation|State Novosibirsk regional clinical hospital, Novosibirsk, 630087, Russian Federation|Limited Law Company "Healthy Family" Medicine Center", Novosibirsk, 630099, Russian Federation|City Hospital #4, Sochi, Sochi, 354057, Russian Federation|Tomsk National Research Medical Center of the RAS, Tomsk, 634034, Russian Federation|Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis., Novi Sad, Vojvodina, 21000, Serbia|CHC Zvezdara, Clinical department for endocrinology, Belgrade, 11000, Serbia|Clinical centre of Serbia, Clinic for cardiology, Belgrade, 11000, Serbia|Clinical Centre of Serbia, Emergency Centre, Department of Cardiology, Belgrade, 11000, Serbia|Emergency Internal Medicine Clinic, Belgrade, 11000, Serbia|Endocrinology, Diabetes and Metabolism Diseases Clinic, Belgrade, 11000, Serbia|Clinical Hospital Centre Zemun, Belgrade, 11080, Serbia|Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department, Kragujevac, 34000, Serbia|University Clinical Centre Nis, Clinic for Cardiology, Nis, 18108, Serbia|Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis., Novi Sad, 21000, Serbia|Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica, Sremska Kamenica, 21204, Serbia|CARDIOCONSULT, s.r.o., Bratislava, 811 04, Slovakia|I. Interna klinika LF UK a UNB, Bratislava, 81369, Slovakia|DIABEDA s.r.o., Bratislava, 831 06, Slovakia|Klinika kardiologie a angiologie LF SZU, Bratislava, 83348, Slovakia|CINRE s. r. o., Oddelenie akutnej kardiologie a koronarna JIS, Bratislava, 841 03, Slovakia|Medical group Kosice s.r.o., Kosice, 040 01, Slovakia|VITAL, s.r.o., Levice, 934 01, Slovakia|Narodny Endokrinologicky a diabetologicky ustav, Lubochna, 03491, Slovakia|KARDIO 1, s.r.o., Kardiologicka ambulancia, Lucenec, 984 01, Slovakia|1. interna klinika, Univerzitna nemocnica Martin, Martin, 036 59, Slovakia|InterStom, s.r.o., Nitra, 949 11, Slovakia|Kardiologicka ambulancia, KARDIOMED NZ, s.r.o., Nove Zamky, 940 01, Slovakia|Medical KG, s.r.o., Piestany, 92101, Slovakia|FNsP J. A. Reimana Presov, Klinika kardiologie, Presov, 08-181, Slovakia|IMCORE, s.r.o., Presov, 080 01, Slovakia|Cardiology Research_Bloemfontein, Bloemfontein, Free State, 9301, South Africa|IATROS International, Bloemfontein, Free State, 9301, South Africa|Josha Research, Bloemfontein, Free State, 9301, South Africa|Dr Iftikhar Osman Ebrahim, Centurion, Gauteng, 0157, South Africa|Wits Bara Clinical Trial Site, Johannesburg, Gauteng, 2013, South Africa|Tickerdoc Research (Pty) LTD, Johannesburg, Gauteng, 2157, South Africa|WITS Clinical Research, Johannesburg, Gauteng, 2193, South Africa|Jongaie Research, Pretoria, Gauteng, 0183, South Africa|Synexus Watermeyer Clinical Research Centre, Pretoria, Gauteng, 0184, South Africa|Clinical Trial Systems (CTC), Pretoria, Gauteng, 0186, South Africa|Roodepoort Medicross Clinical Research Centre, Roodepoort, Gauteng, 1724, South Africa|Mediclinic Medical Centre, Tongaat, KwaZulu-Natal, 4400, South Africa|Helderberg Research Institute, Cape Town, Western Cape, 7130, South Africa|Tread Research (Pty)Ltd, Cape Town, Western Cape, 7500, South Africa|Tiervlei Trial Centre, Cape Town, Western Cape, 7530, South Africa|Prof Rayner_Division of Nephrology, Cape Town, Western Cape, 7925, South Africa|TASK Eden Clinical Research Centre, George, Western Cape, 6529, South Africa|Dr Hendrik Snyman's Practice, Mossel Bay, Western Cape, 6500, South Africa|Paarl Research Centre, Paarl, Western Cape, 7646, South Africa|Paarl Reserch Centre, Paarl, Western Cape, 7646, South Africa|Synexus Helderberg Clinical Research Centre, Somerset West, Western Cape, 7130, South Africa|Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, 28222, Spain|Hospital Virgen de la Arrixaca, El Palmar, Murcia, 30120, Spain|Hospital Universitario de Cruces, Baracaldo, 48903, Spain|Hospital Vithas Sevilla, Castilleja Dela Cuesta Sevilla, 41950, Spain|Hospital Reina Sofia, Córdoba, 14004, Spain|Bellvitge Universitary Hospital, L' Hospitalet Del Llobregat, 08907, Spain|Hospital Virgen del Camino - Sanlúcar de Barrameda, Sanlúcar de Barrameda, 11540, Spain|Hospital Clínico Universitario de Valencia, Valencia, 46010, Spain|Hospital Universitario Doctor Peset, Valencia, 46017, Spain|Hospital Virgen de las Montañas, Villamartin, 11650, Spain|Hospital Universitario Miguel Servet, Zaragoza, 50009, Spain|Karolinska Universitetssjukhuset, Huddinge, Huddinge, Stockholm, 141 85, Sweden|Njurmedicin, Göteborg, 413 45, Sweden|Clemenstorgets Hjärtmottagning, Lund, 222 21, Sweden|Forskningsmottagning Internmedicin (tidigare KFE), Malmö, 205 02, Sweden|Karolinska Universitetssjukhuset Solna,FOU Tema Hjärta Kärl, Stockholm, 171 64, Sweden|Forskning njurmedicin Uppsala, Uppsala, 751 85, Sweden|HsinChu MacKay Memorial Hospital, Hsinchu City, 300, Taiwan|E-DA Hospital, Kaohsiung City, 82445, Taiwan|Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaoshiung, 807, Taiwan|Chi Mei Medical Center, Tainan City, 710, Taiwan|National Cheng Kung University Hospital, Tainan, 704, Taiwan|Taipei Medical University Hospital, Taipei city, 110, Taiwan|National Taiwan University Hospital, Taipei, 100, Taiwan|Cheng Hsin General Hospital, Taipei, 112, Taiwan|Taipei Veterans General Hospital, Taipei, 112, Taiwan|Chang Gung Memorial Hospital Linkou, Taoyuan City, 333, Taiwan|National Yang Ming Chiao Tung University Hospital Lanyang Campus, Yilan City, 260006, Taiwan|Siriraj Hospital, Bangkok Noi, Bangkok, 10700, Thailand|Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Mueang Chiang Mai, 50200, Thailand|Maharat Nakhon Ratchasima Hospital, Mueang Nakhon Ratchasima, Nakhon Ratchasima, 30000, Thailand|Thammasat University Hospital, Klong Luang, Pathumthani, Pathumthani, 12120, Thailand|King Chulalongkorn Memorial Hospital, Bangkok, Patumwan, 10330, Thailand|Phramongkutklao Hospital-nephrology, Bangkok, Rajathewee, 10400, Thailand|Songklanagarind Hospital, Hat Yai, Songkla, 90110, Thailand|Ramathibodi Hospital, Bangkok, Thung Phayathai Subdistrict, 10400, Thailand|Chulabhorn hospital, Bangkok, 10210, Thailand|Cardio-Vajira, Bangkok, 10300, Thailand|King Chulalongkorn Memorial Hospital, Bangkok, 10330, Thailand|Siriraj Hospital, Bangkok, 10700, Thailand|Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, 50200, Thailand|Research Institute for Health Sciences, CMU, Chiang Mai, 50200, Thailand|Srinagarind Hospital, Khon Kaen, 40002, Thailand|Sunpasitthiprasong Hospital, Ubon Ratchathani, 34000, Thailand|Istanbul University Cerrahpasa Medical Faculty, Istanbul, Bakirkoy, 34098, Turkey|Istanbul University Cerrahpasa Medical Faculty, İstanbul, Bakirkoy, 34153, Turkey|Afyonkarahisar Health Sciences University, Afyon, 03200, Turkey|Hacettepe Universitesi Tip Fakultesi Nefroloji Bilim Dali, Ankara, 06230, Turkey|Hacettepe University Medical Faculty_Ankara, Ankara, 06230, Turkey|Akdeniz Universitesi Hastanesi Nefroloji Bilim Dali, Antalya, 07058, Turkey|Aydin Adnan Menderes University Nephrology, Aydin, 09100, Turkey|Trakya University, Edirne, 22030, Turkey|Eskisehir Osmangazi University-Cardio, Eskisehir, 26040, Turkey|Istanbul University Cardiology Institute, Istanbul, 34098, Turkey|Dr. Siyami Ersek Gogus Kalp ve Damar Cerrahisi EAH, Istanbul, 34668, Turkey|Ege University School of Medicine, Cardiology Department, Izmir, 35100, Turkey|Dokuz Eylul University School of Medicine, Cardiology, Izmir, 35340, Turkey|Kahramanmaras Sutcu Imam University, Kahramanmaras, 46040, Turkey|Erciyes University Medial Faculty, Kayseri, 38039, Turkey|Kocaeli University Nephrology Department, Kocaeli, 41380, Turkey|Mersin University Cardiology, Mersin, 33343, Turkey|Mugla Sitki Kocman University Medical Faculty, Mugla, 48050, Turkey|Reg Clin Hospital of Emergency Care, Bukovinian Medical Univ, Chernivtsi, 58023, Ukraine|NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable, Kharkiv, 61039, Ukraine|Municipal Non-Profit Institution "City Clinical Hospital #8", Kharkiv, 61178, Ukraine|Kyiv City Clinical Hospital of Emergency Care - Infarction, Kyiv, 02660, Ukraine|Medbud-Clinic LLC, Kyiv, 03037, Ukraine|Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz, Kyiv, 03049, Ukraine|Ashfields Primary Care Centre, Sandbach, Cheshire, CW11 1EQ, United Kingdom|Royal Bournemouth Hospital, Bournemouth, Dorset, BH7 7DW, United Kingdom|Dorset County Hospital, Dorchester, Dorset, DT1 2JY, United Kingdom|Blackpool Victoria Hospital, Blackpool, Lancashire, FY3 8NR, United Kingdom|Lakeside Healthcare Research & Innovation Unit, Corby, Northamptonshire, NN17 2UR, United Kingdom|Crouch Oak Family Practice, Addlestone, Surrey, KT15 2BH, United Kingdom|St. Richards Hospital, Chichester, West Sussex, PO19 6SE, United Kingdom|Barnet Hospital, Barnet, EN5 3DJ, United Kingdom|The Health Centre, Bradford-on-Avon, BA15 1DQ, United Kingdom|Bradford Royal Infirmary, Bradford, BD9 6RJ, United Kingdom|Southmead Hospital, Bristol, BS10 5NB, United Kingdom|Addenbrooke's Hospital, Cambridge, CB5 8PD, United Kingdom|The Adam Practice, Dorset, BH16 5PW, United Kingdom|Royal Devon University Healthcare NHS Foundation Trust, Exeter, EX2 5DW, United Kingdom|Wycombe General Hospital, High Wycombe, HP11 2TT, United Kingdom|Leicester General Hospital, Leicester, LE5 4PW, United Kingdom|Lincoln County Hospital, Lincoln, LN2 5QY, United Kingdom|University Hospital Aintree, Liverpool, L9 7AL, United Kingdom|William Harvey Clinical Research Centre, London, EC1M 6BQ, United Kingdom|Kings College Hospital, London, SE5 9RS, United Kingdom|Freeman Hospital, Newcastle, Newcastle Upon Tyne, NE7 7DN, United Kingdom|John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom|Pickering Medical Practice, Pickering, YO18 8BL, United Kingdom|Panthera Biopartners Preston, Preston, PR2 9RB, United Kingdom|Lister Hospital, Stevenage, SG1 4AB, United Kingdom|University of North Tees Hospital, Stockton-on-Tees, TS19 8PE, United Kingdom|Cardiology Department, Torquay, TQ2 7AA, United Kingdom|Albany House Medical Centre, Wellingborough, NN8 4RW, United Kingdom
URL: https://clinicaltrials.gov/show/NCT05021835

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress