| Trial ID: | L0088 |
| Source ID: | NCT03471117
|
| Associated Drug: |
Pioglitazone
|
| Title: |
Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients
|
| Acronym: |
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| Status: |
RECRUITING
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Chronic Kidney Diseases
|
| Interventions: |
DRUG: Pioglitazone|OTHER: Placebo
|
| Outcome Measures: |
Primary: Muscle sympathetic nerve activity (MSNA) will be reduced after 1 month of treatment with pioglitazone, Multiunit postganglionic MSNA will be recorded using standard microneurographic techniques. Briefly, a unipolar tungsten microelectrode will be inserted into the peroneal nerve near the fibular head of the leg. Neural signals will be amplified, filtered (bandwidth, 700-2,000 Hz), rectified, and integrated (time constant, 0.1 s) to obtain mean voltage neurograms., 1 month |
|
| Sponsor/Collaborators: |
Sponsor: The University of Texas at Arlington | Collaborators: University of Texas, Southwestern Medical Center at Dallas
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
28
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
|
| Start Date: |
2018-04-01
|
| Completion Date: |
2025-04-01
|
| Results First Posted: |
|
| Last Update Posted: |
2024-05-23
|
| Locations: |
University of Texas at Arlington, Arlington, Texas, 76010, United States|UT Southwestern, Dallas, Texas, 75390, United States
|
| URL: |
https://clinicaltrials.gov/show/NCT03471117
|
