| Outcome Measures: |
Primary: Primary Endpoint: Total heat shock expression in peritoneal cells from dialysate samples;, In this study, an increase of total heat shock protein expression will be detected in cells from the peritoneal effluent at 240 min by staining of the cytospin and by Western blot analysis of the cellular pellet of the effluent. Total heat shock expression from dialysate samples is calculated in percent., up to 70 days | Secondary: Clinical PET-test to measure specific transport kinetics in peritoneal cells (creatinine, urea, sodium, potassium, phosphor, glucose, protein), The ratio of solute concentrations in dialysate and plasma (D/P ratio) at specific times (t) during the dwell signifies the extent of solute equilibration. Creatinine, glucose, urea, electrolytes, phosphate, and proteins are the commonly tested solutes for clinical use, in this study alanine, glutamine and alanyl-glutamine-dipeptide also will be measured to allow assessment of the respective resorption kinetics., up to 70 days|Cell number in peritoneal effluent;, At the end of PD, total peritoneal cell count of the dialysate is measured; Unit of measurement: cells/µl, up to 70 days|cytokines (IL-6, IL-8, TNFα);, At the end of PD cytokines contained in the dialysate are being analysed. Unit of measurement: pg/ml, up to 70 days|Cell function (phagocytosis and cytokine production), Analysis of cell function in dialysate at the end of PD by declaring the contingent of positive cell function in percent;, up to 70 days|Morphology of peritoneal cells from effluent (cell culture), At the end of PD, the cells contained in the dialysate are being differentiated in following categories: ephitelium; non epithelium; mixed., up to 70 days|Biomarker CA125, At the end of PD, the amount of CA125 in the dialysate is measured in U/ml., up to 70 days|Tolerability/safety endpoints: No. and severity of AEs, During the trial and after signing informed consent, the presence/absence/severity of AEs occurring to patients is being documented. Measurement parameter is no. and severity of AEs (including SAEs and SUSARs)., up to 70 days
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