Research Articles
Research articles concerning CKD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in CKDdb are presented with knowledge graphs.
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type 2 diabetes mellitus36 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00008 | 10545531 | J Clin Invest | Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. | 1999 | Details |
| A00009 | 10545951 | Nat Genet | Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. | 1999 | Details |
| A00011 | 10720052 | J Clin Endocrinol Metab | HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients. | 2000 | Details |
| A00021 | 11032784 | Am J Hum Genet | The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. | 2000 | Details |
| A00027 | 11533494 | Science | Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. | 2001 | Details |
| A00028 | 11558907 | J Hum Genet | Single nucleotide polymorphisms of the resistin (RSTN) gene. | 2001 | Details |
| A00036 | 11904371 | Proc Natl Acad Sci U S A | HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community. | 2002 | Details |
| A00040 | 12161522 | J Clin Endocrinol Metab | Nonsense and missense mutations in the human hepatocyte nuclear factor-1 beta gene (TCF2) and their relation to type 2 diabetes in Japanese. | 2002 | Details |
| A00044 | 12679424 | J Clin Endocrinol Metab | A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. | 2003 | Details |
| A00046 | 12727978 | J Clin Endocrinol Metab | A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13. | 2003 | Details |
| A00048 | 12783844 | Hum Mol Genet | Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case - control study. | 2004 | Details |
| A00054 | 1357346 | Lancet | Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. | 1992 | Details |
| A00062 | 15070960 | J Clin Endocrinol Metab | Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. | 2004 | Details |
| A00063 | 15126514 | J Clin Endocrinol Metab | The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. | 2004 | Details |
| A00065 | 15166380 | Science | A family with severe insulin resistance and diabetes due to a mutation in AKT2. | 2004 | Details |
| A00070 | 15924147 | Nat Med | Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. | 2005 | Details |
| A00071 | 15940393 | J Hum Genet | Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. | 2005 | Details |
| A00076 | 16142453 | Hum Genet | Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. | 2006 | Details |
| A00079 | 16415884 | Nat Genet | Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. | 2006 | Details |
| A00089 | 17273962 | Am J Hum Genet | Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. | 2007 | Details |
| A00090 | 17293876 | Nature | A genome-wide association study identifies novel risk loci for type 2 diabetes. | 2007 | Details |
| A00102 | 17652184 | Mol Endocrinol | Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. | 2008 | Details |
| A00108 | 18097733 | J Hum Genet | Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. | 2008 | Details |
| A00116 | 18711367 | Nat Genet | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. | 2009 | Details |
| A00119 | 19020323 | N Engl J Med | Genotype score in addition to common risk factors for prediction of type 2 diabetes. | 2008 | Details |
| A00120 | 19020324 | N Engl J Med | Clinical risk factors, DNA variants, and the development of type 2 diabetes. | 2008 | Details |
| A00129 | 20085713 | Am J Hum Genet | Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. | 2010 | Details |
| A00134 | 20574426 | J Hum Genet | The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. | 2011 | Details |
| A00138 | 21364139 | JAMA | Functional variants of the HMGA1 gene and type 2 diabetes mellitus. | 2011 | Details |
| A00167 | 27896077 | Mol Genet Metab Rep | Sequencing analysis of insulin receptor defects and detection of two novel mutations in <i>INSR</i> gene. | 2020 | Details |
| A00168 | 27908292 | Orphanet J Rare Dis | Conservatively treated Congenital Hyperinsulinism (CHI) due to K-ATP channel gene mutations: reducing severity over time. | 2017 | Details |
| A00171 | 28838955 | J Am Soc Nephrol | Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease. | 2017 | Details |
| A00177 | 30422235 | JAMA | Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial. | 2018 | Details |
| A00178 | 30927425 | Hum Reprod | Factors influencing the clinical outcome of preimplantation genetic testing for polycystic kidney disease. | 2020 | Details |
| A00202 | 39816051 | Narra J | Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial. | 2025 | Details |
| A00204 | 39873191 | Gut Microbes | Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet. | 2025 | Details |