Research Article Details
Article ID: | A00168 |
PMID: | 27908292 |
Source: | Orphanet J Rare Dis |
Title: | Conservatively treated Congenital Hyperinsulinism (CHI) due to K-ATP channel gene mutations: reducing severity over time. |
Abstract: | Patients with Congenital Hyperinsulinism (CHI) due to mutations in K-ATP channel genes (K-ATP CHI) are increasingly treated by conservative medical therapy without pancreatic surgery. However, the natural history of medically treated K-ATP CHI has not been described; it is unclear if the severity of recessively and dominantly inherited K-ATP CHI reduces over time. We aimed to review variation in severity and outcomes in patients with K-ATP CHI treated by medical therapy. Twenty-one consecutively presenting patients with K-ATP CHI with dominantly and recessively inherited mutations in ABCC8/KCNJ11 were selected in a specialised CHI treatment centre to review treatment outcomes. Medical treatment included diazoxide and somatostatin receptor agonists (SSRA), octreotide and somatuline autogel. CHI severity was assessed by glucose infusion rate (GIR), medication dosage and tendency to resolution. CHI outcome was assessed by glycaemic profile, fasting tolerance and neurodevelopment. CHI presenting at median (range) age 1 (1, 240) days resolved in 15 (71%) patients at age 3.1(0.2, 13.0) years. Resolution was achieved both in patients responsive to diazoxide (n = 8, 57%) and patients responsive to SSRA (n = 7, 100%) with earlier resolution in the former [1.6 (0.2, 13.0) v 5.9 (1.6, 9.0) years, p = 0.08]. In 6 patients remaining on treatment, diazoxide dose was reduced in follow up [10.0 (8.5, 15.0) to 5.4 (0.5, 10.8) mg/kg/day, p = 0.003]. GIR at presentation did not correlate with resolved or persistent CHI [14.9 (10.0, 18.5) v 16.5 (13.0, 20.0) mg/kg/min, p = 0.6]. The type of gene mutation did not predict persistence; resolution could be achieved in recessively-inherited CHI with homozygous (n = 3), compound heterozygous (n = 2) and paternal mutations causing focal CHI (n = 2). Mild developmental delay was present in 8 (38%) patients; adaptive functioning assessed by Vineland Adaptive Behavior Scales questionnaire showed a trend towards higher standard deviation scores (SDS) in resolved than persistent CHI [-0.1 (-1.2, 1.6) v -1.2 (-1.7, 0.03), p = 0.1]. In K-ATP CHI patients managed by medical treatment only, severity is reduced over time in the majority, including those with compound heterozygous and homozygous mutations in ABCC8/KCNJ11. Severity and treatment requirement should be assessed periodically in all children with K-ATP CHI on medical therapy. |
DOI: | 10.1186/s13023-016-0547-3 |

Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
---|
Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
---|
Diseases ID | DO ID | Disease Name | Definition | Class | |
---|---|---|---|---|---|
I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details | |
I07 | 9352 | type 2 diabetes mellitus | "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." [url:http\://en.wikipedia.org/wiki/Diabetes, url:http\://en.wikipedia.org/wiki/Diabetes_mellitus_type_2] | Details |
Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
---|---|---|---|---|---|---|---|
D001 | Leuprolide | small molecule | DB00007 | Details | |||
D002 | Goserelin | small molecule | DB00014 | Details | |||
D003 | Cetrorelix | small molecule | DB00050 | Details | |||
D004 | Pyridoxal phosphate | small molecule | DB00114 | Details | |||
D005 | Histidine | small molecule | DB00117 | Details | |||
D006 | Phenylalanine | small molecule | DB00120 | Details | |||
D007 | Biotin | small molecule | DB00121 | Details | |||
D008 | Choline | small molecule | DB00122 | Details | |||
D009 | L-Lysine | small molecule | DB00123 | Details | |||
D010 | Arginine | small molecule | DB00125 | Details | |||
D011 | Ascorbic acid | small molecule | DB00126 | Details | |||
D012 | Aspartic acid | small molecule | DB00128 | Details | |||
D013 | Ornithine | small molecule | DB00129 | Details | |||
D014 | L-Glutamine | small molecule | DB00130 | Details | |||
D015 | Serine | small molecule | DB00133 | Details | |||
D016 | Methionine | small molecule | DB00134 | Details | |||
D017 | Tyrosine | small molecule | DB00135 | Details | |||
D018 | Calcitriol | small molecule | DB00136 | Details | |||
D019 | Lutein | small molecule | DB00137 | Details | |||
D020 | Riboflavin | small molecule | DB00140 | Details | |||
D021 | Glutamic acid | small molecule | DB00142 | Details | |||
D022 | Phosphatidyl serine | small molecule | DB00144 | Details | |||
D023 | Glycine | small molecule | DB00145 | Details | |||
D024 | Calcifediol | small molecule | DB00146 | Details | |||
D025 | Pyridoxal | small molecule | DB00147 | Details | |||
D026 | Creatine | small molecule | DB00148 | Details | |||
D027 | Leucine | small molecule | DB00149 | Details | |||
D028 | Tryptophan | small molecule | DB00150 | Details | |||
D029 | Cysteine | small molecule | DB00151 | Details | |||
D030 | Thiamine | small molecule | DB00152 | Details | |||
D031 | Ergocalciferol | small molecule | DB00153 | Details | |||
D032 | Threonine | small molecule | DB00156 | Details | |||
D033 | Alanine | small molecule | DB00160 | Details | |||
D034 | Valine | small molecule | DB00161 | Details | |||
D035 | Vitamin A | small molecule | DB00162 | Details | |||
D036 | Vitamin E | small molecule | DB00163 | Details | |||
D037 | Pyridoxine | small molecule | DB00165 | Details | |||
D038 | Isoleucine | small molecule | DB00167 | Details | |||
D039 | Cholecalciferol | small molecule | DB00169 | Details | |||
D040 | Menadione | small molecule | DB00170 | Details | |||
D041 | Proline | small molecule | DB00172 | Details | |||
D042 | Pravastatin | small molecule | DB00175 | Details | |||
D043 | Valsartan | small molecule | DB00177 | Details | |||
D044 | Ramipril | small molecule | DB00178 | Details | |||
D045 | Esmolol | small molecule | DB00187 | Details | |||
D046 | Bortezomib | small molecule | DB00188 | Details | |||
D047 | Phentermine | small molecule | DB00191 | Details | |||
D048 | Tramadol | small molecule | DB00193 | Details | |||
D049 | Fluconazole | small molecule | DB00196 | Details | |||
D050 | Troglitazone | small molecule | DB00197 | Details | |||
D051 | Oseltamivir | small molecule | DB00198 | Details | |||
D052 | Erythromycin | small molecule | DB00199 | Details | |||
D053 | Caffeine | small molecule | DB00201 | Details | |||
D054 | Reserpine | small molecule | DB00206 | Details | |||
D055 | Azithromycin | small molecule | DB00207 | Details | |||
D056 | Pantoprazole | small molecule | DB00213 | Details | |||
D057 | Torasemide | small molecule | DB00214 | Details | |||
D058 | Citalopram | small molecule | DB00215 | Details | |||
D059 | Moxifloxacin | small molecule | DB00218 | Details | |||
D060 | Indinavir | small molecule | DB00224 | Details | |||
D061 | Lovastatin | small molecule | DB00227 | Details | |||
D062 | Pregabalin | small molecule | DB00230 | Details | |||
D063 | Nevirapine | small molecule | DB00238 | Details | |||
D064 | Ranolazine | small molecule | DB00243 | Details | |||
D065 | Ziprasidone | small molecule | DB00246 | Details | |||
D066 | Doxycycline | small molecule | DB00254 | Details | |||
D067 | Clotrimazole | small molecule | DB00257 | Details | |||
D068 | Metoprolol | small molecule | DB00264 | Details | |||
D069 | Ropinirole | small molecule | DB00268 | Details | |||
D070 | Chlorotrianisene | small molecule | DB00269 | Details | |||
D071 | Topiramate | small molecule | DB00273 | Details | |||
D072 | Olmesartan | small molecule | DB00275 | Details | |||
D073 | Theophylline | small molecule | DB00277 | Details | |||
D074 | Lidocaine | small molecule | DB00281 | Details | |||
D075 | Pamidronic acid | small molecule | DB00282 | Details | |||
D076 | Chlorambucil | small molecule | DB00291 | Details | |||
D077 | Morphine | small molecule | DB00295 | Details | |||
D078 | Bupivacaine | small molecule | DB00297 | Details | |||
D079 | Tranexamic acid | small molecule | DB00302 | Details | |||
D080 | Ertapenem | small molecule | DB00303 | Details | |||
D081 | Mitomycin | small molecule | DB00305 | Details | |||
D082 | Chlorthalidone | small molecule | DB00310 | Details | |||
D083 | Valproic acid | small molecule | DB00313 | Details | |||
D084 | Acetaminophen | small molecule | DB00316 | Details | |||
D085 | Piperacillin | small molecule | DB00319 | Details | |||
D086 | Amitriptyline | small molecule | DB00321 | Details | |||
D087 | Nitroprusside | small molecule | DB00325 | Details | |||
D088 | Indomethacin | small molecule | DB00328 | Details | |||
D089 | Metformin | small molecule | DB00331 | Details | |||
D090 | Methadone | small molecule | DB00333 | Details | |||
D091 | Olanzapine | small molecule | DB00334 | Details | |||
D092 | Atenolol | small molecule | DB00335 | Details | |||
D093 | Cetirizine | small molecule | DB00341 | Details | |||
D094 | Diltiazem | small molecule | DB00343 | Details | |||
D095 | Minoxidil | small molecule | DB00350 | Details | |||
D096 | Chlorzoxazone | small molecule | DB00356 | Details | |||
D097 | Clozapine | small molecule | DB00363 | Details | |||
D098 | Levonorgestrel | small molecule | DB00367 | Details | |||
D099 | Norepinephrine | small molecule | DB00368 | Details | |||
D100 | Cidofovir | small molecule | DB00369 | Details | |||
D101 | Mirtazapine | small molecule | DB00370 | Details | |||
D102 | Treprostinil | small molecule | DB00374 | Details | |||
D103 | Dydrogesterone | small molecule | DB00378 | Details | |||
D104 | Amlodipine | small molecule | DB00381 | Details | |||
D105 | Triamterene | small molecule | DB00384 | Details | |||
D106 | Phenylephrine | small molecule | DB00388 | Details | |||
D107 | Digoxin | small molecule | DB00390 | Details | |||
D108 | Nimodipine | small molecule | DB00393 | Details | |||
D109 | Progesterone | small molecule | DB00396 | Details | |||
D110 | Sorafenib | small molecule | DB00398 | Details | |||
D111 | Zoledronic acid | small molecule | DB00399 | Details | |||
D112 | Eszopiclone | small molecule | DB00402 | Details | |||
D113 | Alprazolam | small molecule | DB00404 | Details | |||
D114 | Loxapine | small molecule | DB00408 | Details | |||
D115 | Mupirocin | small molecule | DB00410 | Details | |||
D116 | Rosiglitazone | small molecule | DB00412 | Details | |||
D117 | Acetohexamide | small molecule | DB00414 | Details | |||
D118 | Ampicillin | small molecule | DB00415 | Details | |||
D119 | Spironolactone | small molecule | DB00421 | Details | |||
D120 | Methocarbamol | small molecule | DB00423 | Details | |||
D121 | Zolpidem | small molecule | DB00425 | Details | |||
D122 | Nitric Oxide | small molecule | DB00435 | Details | |||
D123 | Ceftazidime | small molecule | DB00438 | Details | |||
D124 | Trimethoprim | small molecule | DB00440 | Details | |||
D125 | Betamethasone | small molecule | DB00443 | Details | |||
D126 | Lansoprazole | small molecule | DB00448 | Details | |||
D127 | Loratadine | small molecule | DB00455 | Details | |||
D128 | Imipramine | small molecule | DB00458 | Details | |||
D129 | Dronabinol | small molecule | DB00470 | Details | |||
D130 | Montelukast | small molecule | DB00471 | Details | |||
D131 | Fluoxetine | small molecule | DB00472 | Details | |||
D132 | Duloxetine | small molecule | DB00476 | Details | |||
D133 | Chlorpromazine | small molecule | DB00477 | Details | |||
D134 | Amikacin | small molecule | DB00479 | Details | |||
D135 | Lenalidomide | small molecule | DB00480 | Details | |||
D136 | Celecoxib | small molecule | DB00482 | Details | |||
D137 | Altretamine | small molecule | DB00488 | Details | |||
D138 | Miglitol | small molecule | DB00491 | Details | |||
D139 | Cefotaxime | small molecule | DB00493 | Details | |||
D140 | Zidovudine | small molecule | DB00495 | Details | |||
D141 | Oxycodone | small molecule | DB00497 | Details | |||
D142 | Cimetidine | small molecule | DB00501 | Details | |||
D143 | Ritonavir | small molecule | DB00503 | Details | |||
D144 | Nitazoxanide | small molecule | DB00507 | Details | |||
D145 | Vancomycin | small molecule | DB00512 | Details | |||
D146 | Aminocaproic acid | small molecule | DB00513 | Details | |||
D147 | Trandolapril | small molecule | DB00519 | Details | |||
D148 | Metolazone | small molecule | DB00524 | Details | |||
D149 | Tolnaftate | small molecule | DB00525 | Details | |||
D150 | Lercanidipine | small molecule | DB00528 | Details | |||
D151 | Cyclophosphamide | small molecule | DB00531 | Details | |||
D152 | Ciprofloxacin | small molecule | DB00537 | Details | |||
D153 | Benazepril | small molecule | DB00542 | Details | |||
D154 | Propylthiouracil | small molecule | DB00550 | Details | |||
D155 | Zanamivir | small molecule | DB00558 | Details | |||
D156 | Bosentan | small molecule | DB00559 | Details | |||
D157 | Methotrexate | small molecule | DB00563 | Details | |||
D158 | Cisatracurium | small molecule | DB00565 | Details | |||
D159 | Cephalexin | small molecule | DB00567 | Details | |||
D160 | Propranolol | small molecule | DB00571 | Details | |||
D161 | Atropine | small molecule | DB00572 | Details | |||
D162 | Clonidine | small molecule | DB00575 | Details | |||
D163 | Lactulose | small molecule | DB00581 | Details | |||
D164 | Voriconazole | small molecule | DB00582 | Details | |||
D165 | Diclofenac | small molecule | DB00586 | Details | |||
D166 | Doxazosin | small molecule | DB00590 | Details | |||
D167 | Amiloride | small molecule | DB00594 | Details | |||
D168 | Labetalol | small molecule | DB00598 | Details | |||
D169 | Thiopental | small molecule | DB00599 | Details | |||
D170 | Linezolid | small molecule | DB00601 | Details | |||
D171 | Cisapride | small molecule | DB00604 | Details | |||
D172 | Nafcillin | small molecule | DB00607 | Details | |||
D173 | Chloroquine | small molecule | DB00608 | Details | |||
D174 | Bisoprolol | small molecule | DB00612 | Details | |||
D175 | Fluphenazine | small molecule | DB00623 | Details | |||
D176 | Testosterone | small molecule | DB00624 | Details | |||
D177 | Efavirenz | small molecule | DB00625 | Details | |||
D178 | Bacitracin | small molecule | DB00626 | Details | |||
D179 | Niacin | small molecule | DB00627 | Details | |||
D180 | Alendronic acid | small molecule | DB00630 | Details | |||
D181 | Prednisone | small molecule | DB00635 | Details | |||
D182 | Inulin | small molecule | DB00638 | Details | |||
D183 | Adenosine | small molecule | DB00640 | Details | |||
D184 | Simvastatin | small molecule | DB00641 | Details | |||
D185 | Stavudine | small molecule | DB00649 | Details | |||
D186 | Trazodone | small molecule | DB00656 | Details | |||
D187 | Verapamil | small molecule | DB00661 | Details | |||
D188 | Epinephrine | small molecule | DB00668 | Details | |||
D189 | Pirenzepine | small molecule | DB00670 | Details | |||
D190 | Cefixime | small molecule | DB00671 | Details | |||
D191 | Chlorpropamide | small molecule | DB00672 | Details | |||
D192 | Losartan | small molecule | DB00678 | Details | |||
D193 | Thioridazine | small molecule | DB00679 | Details | |||
D194 | Warfarin | small molecule | DB00682 | Details | |||
D195 | Midazolam | small molecule | DB00683 | Details | |||
D196 | Tobramycin | small molecule | DB00684 | Details | |||
D197 | Fludrocortisone | small molecule | DB00687 | Details | |||
D198 | Phentolamine | small molecule | DB00692 | Details | |||
D199 | Furosemide | small molecule | DB00695 | Details | |||
D200 | Eplerenone | small molecule | DB00700 | Details | |||
D201 | Amprenavir | small molecule | DB00701 | Details | |||
D202 | Naltrexone | small molecule | DB00704 | Details | |||
D203 | Tamsulosin | small molecule | DB00706 | Details | |||
D204 | Lamivudine | small molecule | DB00709 | Details | |||
D205 | Ibandronate | small molecule | DB00710 | Details | |||
D206 | Flurbiprofen | small molecule | DB00712 | Details | |||
D207 | Oxacillin | small molecule | DB00713 | Details | |||
D208 | Paroxetine | small molecule | DB00715 | Details | |||
D209 | Lisinopril | small molecule | DB00722 | Details | |||
D210 | Nitroglycerin | small molecule | DB00727 | Details | |||
D211 | Rocuronium | small molecule | DB00728 | Details | |||
D212 | Risperidone | small molecule | DB00734 | Details | |||
D213 | Esomeprazole | small molecule | DB00736 | Details | |||
D214 | Pentamidine | small molecule | DB00738 | Details | |||
D215 | Hydrocortisone | small molecule | DB00741 | Details | |||
D216 | Mannitol | small molecule | DB00742 | Details | |||
D217 | Deferoxamine | small molecule | DB00746 | Details | |||
D218 | Prilocaine | small molecule | DB00750 | Details | |||
D219 | Isoflurane | small molecule | DB00753 | Details | |||
D220 | Clopidogrel | small molecule | DB00758 | Details | |||
D221 | Methimazole | small molecule | DB00763 | Details | |||
D222 | Clavulanic acid | small molecule | DB00766 | Details | |||
D223 | Alprostadil | small molecule | DB00770 | Details | |||
D224 | Mefenamic acid | small molecule | DB00784 | Details | |||
D225 | Perindopril | small molecule | DB00790 | Details | |||
D226 | Alfentanil | small molecule | DB00802 | Details | |||
D227 | Pentoxifylline | small molecule | DB00806 | Details | |||
D228 | Indapamide | small molecule | DB00808 | Details | |||
D229 | Tropicamide | small molecule | DB00809 | Details | |||
D230 | Ribavirin | small molecule | DB00811 | Details | |||
D231 | Fentanyl | small molecule | DB00813 | Details | |||
D232 | Propofol | small molecule | DB00818 | Details | |||
D233 | Acetazolamide | small molecule | DB00819 | Details | |||
D234 | Tadalafil | small molecule | DB00820 | Details | |||
D235 | Fosfomycin | small molecule | DB00828 | Details | |||
D236 | Diazepam | small molecule | DB00829 | Details | |||
D237 | Trifluoperazine | small molecule | DB00831 | Details | |||
D238 | Mifepristone | small molecule | DB00834 | Details | |||
D239 | Tolazamide | small molecule | DB00839 | Details | |||
D240 | Dobutamine | small molecule | DB00841 | Details | |||
D241 | Donepezil | small molecule | DB00843 | Details | |||
D242 | Nalbuphine | small molecule | DB00844 | Details | |||
D243 | Levamisole | small molecule | DB00848 | Details | |||
D244 | Perphenazine | small molecule | DB00850 | Details | |||
D245 | Pseudoephedrine | small molecule | DB00852 | Details | |||
D246 | Aminolevulinic acid | small molecule | DB00855 | Details | |||
D247 | Terbinafine | small molecule | DB00857 | Details | |||
D248 | Prednisolone | small molecule | DB00860 | Details | |||
D249 | Diflunisal | small molecule | DB00861 | Details | |||
D250 | Terbutaline | small molecule | DB00871 | Details | |||
D251 | Guaifenesin | small molecule | DB00874 | Details | |||
D252 | Eprosartan | small molecule | DB00876 | Details | |||
D253 | Sirolimus | small molecule | DB00877 | Details | |||
D254 | Emtricitabine | small molecule | DB00879 | Details | |||
D255 | Quinapril | small molecule | DB00881 | Details | |||
D256 | Isosorbide dinitrate | small molecule | DB00883 | Details | |||
D257 | Mechlorethamine | small molecule | DB00888 | Details | |||
D258 | Ethanol | small molecule | DB00898 | Details | |||
D259 | Remifentanil | small molecule | DB00899 | Details | |||
D260 | Ondansetron | small molecule | DB00904 | Details | |||
D261 | Cocaine | small molecule | DB00907 | Details | |||
D262 | Repaglinide | small molecule | DB00912 | Details | |||
D263 | Phenformin | small molecule | DB00914 | Details | |||
D264 | Amantadine | small molecule | DB00915 | Details | |||
D265 | Metronidazole | small molecule | DB00916 | Details | |||
D266 | Dinoprostone | small molecule | DB00917 | Details | |||
D267 | Buprenorphine | small molecule | DB00921 | Details | |||
D268 | Azacitidine | small molecule | DB00928 | Details | |||
D269 | Misoprostol | small molecule | DB00929 | Details | |||
D270 | Mesoridazine | small molecule | DB00933 | Details | |||
D271 | Oxymetazoline | small molecule | DB00935 | Details | |||
D272 | Salicylic acid | small molecule | DB00936 | Details | |||
D273 | Acetylsalicylic acid | small molecule | DB00945 | Details | |||
D274 | Phenprocoumon | small molecule | DB00946 | Details | |||
D275 | Fexofenadine | small molecule | DB00950 | Details | |||
D276 | Isoniazid | small molecule | DB00951 | Details | |||
D277 | Norgestimate | small molecule | DB00957 | Details | |||
D278 | Methylprednisolone | small molecule | DB00959 | Details | |||
D279 | Mepivacaine | small molecule | DB00961 | Details | |||
D280 | Zaleplon | small molecule | DB00962 | Details | |||
D281 | Bromfenac | small molecule | DB00963 | Details | |||
D282 | Telmisartan | small molecule | DB00966 | Details | |||
D283 | Methyldopa | small molecule | DB00968 | Details | |||
D284 | Ezetimibe | small molecule | DB00973 | Details | |||
D285 | Edetic acid | small molecule | DB00974 | Details | |||
D286 | Dipyridamole | small molecule | DB00975 | Details | |||
D287 | Ethinylestradiol | small molecule | DB00977 | Details | |||
D288 | Physostigmine | small molecule | DB00981 | Details | |||
D289 | Isotretinoin | small molecule | DB00982 | Details | |||
D290 | Nandrolone phenpropionate | small molecule | DB00984 | Details | |||
D291 | Glycopyrronium | small molecule | DB00986 | Details | |||
D292 | Dopamine | small molecule | DB00988 | Details | |||
D293 | Azathioprine | small molecule | DB00993 | Details | |||
D294 | Gabapentin | small molecule | DB00996 | Details | |||
D295 | Frovatriptan | small molecule | DB00998 | Details | |||
D296 | Hydrochlorothiazide | small molecule | DB00999 | Details | |||
D297 | Salbutamol | small molecule | DB01001 | Details | |||
D298 | Levobupivacaine | small molecule | DB01002 | Details | |||
D299 | Hydroxyurea | small molecule | DB01005 | Details | |||
D300 | Letrozole | small molecule | DB01006 | Details | |||
D301 | Metyrapone | small molecule | DB01011 | Details | |||
D302 | Cinacalcet | small molecule | DB01012 | Details | |||
D303 | Sulfamethoxazole | small molecule | DB01015 | Details | |||
D304 | Bethanechol | small molecule | DB01019 | Details | |||
D305 | Phylloquinone | small molecule | DB01022 | Details | |||
D306 | Felodipine | small molecule | DB01023 | Details | |||
D307 | Mycophenolic acid | small molecule | DB01024 | Details | |||
D308 | Amlexanox | small molecule | DB01025 | Details | |||
D309 | Irbesartan | small molecule | DB01029 | Details | |||
D310 | Probenecid | small molecule | DB01032 | Details | |||
D311 | Fenofibrate | small molecule | DB01039 | Details | |||
D312 | Thalidomide | small molecule | DB01041 | Details | |||
D313 | Ibuprofen | small molecule | DB01050 | Details | |||
D314 | Benzylpenicillin | small molecule | DB01053 | Details | |||
D315 | Amoxicillin | small molecule | DB01060 | Details | |||
D316 | Melatonin | small molecule | DB01065 | Details | |||
D317 | Glipizide | small molecule | DB01067 | Details | |||
D318 | Promethazine | small molecule | DB01069 | Details | |||
D319 | Diphenhydramine | small molecule | DB01075 | Details | |||
D320 | Atorvastatin | small molecule | DB01076 | Details | |||
D321 | Vigabatrin | small molecule | DB01080 | Details | |||
D322 | Streptomycin | small molecule | DB01082 | Details | |||
D323 | Orlistat | small molecule | DB01083 | Details | |||
D324 | Pilocarpine | small molecule | DB01085 | Details | |||
D325 | Benzocaine | small molecule | DB01086 | Details | |||
D326 | Dimethyl sulfoxide | small molecule | DB01093 | Details | |||
D327 | Pimozide | small molecule | DB01100 | Details | |||
D328 | Sertraline | small molecule | DB01104 | Details | |||
D329 | Miconazole | small molecule | DB01110 | Details | |||
D330 | Nifedipine | small molecule | DB01115 | Details | |||
D331 | Amiodarone | small molecule | DB01118 | Details | |||
D332 | Diazoxide | small molecule | DB01119 | Details | |||
D333 | Gliclazide | small molecule | DB01120 | Details | |||
D334 | Tolbutamide | small molecule | DB01124 | Details | |||
D335 | Dutasteride | small molecule | DB01126 | Details | |||
D336 | Pioglitazone | small molecule | DB01132 | Details | |||
D337 | Carvedilol | small molecule | DB01136 | Details | |||
D338 | Levofloxacin | small molecule | DB01137 | Details | |||
D339 | Cefadroxil | small molecule | DB01140 | Details | |||
D340 | Bupropion | small molecule | DB01156 | Details | |||
D341 | Terazosin | small molecule | DB01162 | Details | |||
D342 | Ofloxacin | small molecule | DB01165 | Details | |||
D343 | Cilostazol | small molecule | DB01166 | Details | |||
D344 | Itraconazole | small molecule | DB01167 | Details | |||
D345 | Chlormezanone | small molecule | DB01178 | Details | |||
D346 | Naloxone | small molecule | DB01183 | Details | |||
D347 | Domperidone | small molecule | DB01184 | Details | |||
D348 | Ciclopirox | small molecule | DB01188 | Details | |||
D349 | Desflurane | small molecule | DB01189 | Details | |||
D350 | Clindamycin | small molecule | DB01190 | Details | |||
D351 | Dexfenfluramine | small molecule | DB01191 | Details | |||
D352 | Captopril | small molecule | DB01197 | Details | |||
D353 | Zopiclone | small molecule | DB01198 | Details | |||
D354 | Bromocriptine | small molecule | DB01200 | Details | |||
D355 | Clarithromycin | small molecule | DB01211 | Details | |||
D356 | Ceftriaxone | small molecule | DB01212 | Details | |||
D357 | Anastrozole | small molecule | DB01217 | Details | |||
D358 | Dantrolene | small molecule | DB01219 | Details | |||
D359 | Budesonide | small molecule | DB01222 | Details | |||
D360 | Quetiapine | small molecule | DB01224 | Details | |||
D361 | Paclitaxel | small molecule | DB01229 | Details | |||
D362 | Metoclopramide | small molecule | DB01233 | Details | |||
D363 | Dexamethasone | small molecule | DB01234 | Details | |||
D364 | Sevoflurane | small molecule | DB01236 | Details | |||
D365 | Aripiprazole | small molecule | DB01238 | Details | |||
D366 | Epoprostenol | small molecule | DB01240 | Details | |||
D367 | Gliquidone | small molecule | DB01251 | Details | |||
D368 | Dasatinib | small molecule | DB01254 | Details | |||
D369 | Lapatinib | small molecule | DB01259 | Details | |||
D370 | Darunavir | small molecule | DB01264 | Details | |||
D371 | Sunitinib | small molecule | DB01268 | Details | |||
D372 | Hydralazine | small molecule | DB01275 | Details | |||
D373 | Lumiracoxib | small molecule | DB01283 | Details | |||
D374 | Glucosamine | small molecule | DB01296 | Details | |||
D375 | Cefazolin | small molecule | DB01327 | Details | |||
D376 | Vecuronium | small molecule | DB01339 | Details | |||
D377 | Cilazapril | small molecule | DB01340 | Details | |||
D378 | Spirapril | small molecule | DB01348 | Details | |||
D379 | Ephedrine | small molecule | DB01364 | Details | |||
D380 | Yohimbine | small molecule | DB01392 | Details | |||
D381 | Bezafibrate | small molecule | DB01393 | Details | |||
D382 | Colchicine | small molecule | DB01394 | Details | |||
D383 | Drospirenone | small molecule | DB01395 | Details | |||
D384 | Methotrimeprazine | small molecule | DB01403 | Details | |||
D385 | Clenbuterol | small molecule | DB01407 | Details | |||
D386 | Theobromine | small molecule | DB01412 | Details | |||
D387 | Cefepime | small molecule | DB01413 | Details | |||
D388 | Alfacalcidol | small molecule | DB01436 | Details | |||
D389 | Diamorphine | small molecule | DB01452 | Details | |||
D390 | Metamfetamine | small molecule | DB01577 | Details | |||
D391 | Sulfamethazine | small molecule | DB01582 | Details | |||
D392 | Ursodeoxycholic acid | small molecule | DB01586 | Details | |||
D393 | Probucol | small molecule | DB01599 | Details | |||
D394 | Lopinavir | small molecule | DB01601 | Details | |||
D395 | Tazobactam | small molecule | DB01606 | Details | |||
D396 | Hydroxychloroquine | small molecule | DB01611 | Details | |||
D397 | Molindone | small molecule | DB01618 | Details | |||
D398 | Thiothixene | small molecule | DB01623 | Details | |||
D399 | Sorbitol | small molecule | DB01638 | Details | |||
D400 | Genistein | small molecule | DB01645 | Details | |||
D401 | N,N-dimethylarginine | small molecule | DB01686 | Details | |||
D402 | Prasterone | small molecule | DB01708 | Details | |||
D403 | Pantothenic acid | small molecule | DB01783 | Details | |||
D404 | Taurine | small molecule | DB01956 | Details | |||
D405 | Calcipotriol | small molecule | DB02300 | Details | |||
D406 | Thymol | small molecule | DB02513 | Details | |||
D407 | gamma-Aminobutyric acid | small molecule | DB02530 | Details | |||
D408 | Terlipressin | small molecule | DB02638 | Details | |||
D409 | Nicotinamide | small molecule | DB02701 | Details | |||
D410 | Fusidic acid | small molecule | DB02703 | Details | |||
D411 | Resveratrol | small molecule | DB02709 | Details | |||
D412 | Oxitriptan | small molecule | DB02959 | Details | |||
D413 | Glycolic acid | small molecule | DB03085 | Details | |||
D414 | Acetylcholine | small molecule | DB03128 | Details | |||
D415 | Acetic acid | small molecule | DB03166 | Details | |||
D416 | Phenol | small molecule | DB03255 | Details | |||
D417 | Palmitic Acid | small molecule | DB03796 | Details | |||
D418 | Eucalyptol | small molecule | DB03852 | Details | |||
D419 | Citric acid | small molecule | DB04272 | Details | |||
D420 | Maleic Acid | small molecule | DB04299 | Details | |||
D421 | N,N,N-trimethylglycinium | small molecule | DB04455 | Details | |||
D422 | Meso-Erythritol | small molecule | DB04481 | Details | |||
D423 | Indole | small molecule | DB04532 | Details | |||
D424 | Arachidonic Acid | small molecule | DB04557 | Details | |||
D425 | Buformin | small molecule | DB04830 | Details | |||
D426 | Methaqualone | small molecule | DB04833 | Details | |||
D427 | Cyproterone acetate | small molecule | DB04839 | Details | |||
D428 | Fluspirilene | small molecule | DB04842 | Details | |||
D429 | Tetrabenazine | small molecule | DB04844 | Details | |||
D430 | Febuxostat | small molecule | DB04854 | Details | |||
D431 | Nebivolol | small molecule | DB04861 | Details | |||
D432 | Vildagliptin | small molecule | DB04876 | Details | |||
D433 | Voglibose | small molecule | DB04878 | Details | |||
D434 | Iloperidone | small molecule | DB04946 | Details | |||
D435 | Lobeline | small molecule | DB05137 | Details | |||
D436 | Histamine | small molecule | DB05381 | Details | |||
D437 | Iodine | small molecule | DB05382 | Details | |||
D438 | Levoketoconazole | small molecule | DB05667 | Details | |||
D439 | Acetylcysteine | small molecule | DB06151 | Details | |||
D440 | Atrasentan | small molecule | DB06199 | Details | |||
D441 | Rivaroxaban | small molecule | DB06228 | Details | |||
D442 | Eflornithine | small molecule | DB06243 | Details | |||
D443 | Sitaxentan | small molecule | DB06268 | Details | |||
D444 | Amisulpride | small molecule | DB06288 | Details | |||
D445 | Dapagliflozin | small molecule | DB06292 | Details | |||
D446 | Darapladib | small molecule | DB06311 | Details | |||
D447 | Saxagliptin | small molecule | DB06335 | Details | |||
D448 | Ambrisentan | small molecule | DB06403 | Details | |||
D449 | Etravirine | small molecule | DB06414 | Details | |||
D450 | Prucalopride | small molecule | DB06480 | Details | |||
D451 | Cetilistat | small molecule | DB06586 | Details | |||
D452 | Agomelatine | small molecule | DB06594 | Details | |||
D453 | Apixaban | small molecule | DB06605 | Details | |||
D454 | Bosutinib | small molecule | DB06616 | Details | |||
D455 | Desvenlafaxine | small molecule | DB06700 | Details | |||
D456 | Methyltestosterone | small molecule | DB06710 | Details | |||
D457 | Beta carotene | small molecule | DB06755 | Details | |||
D458 | Manganese | small molecule | DB06757 | Details | |||
D459 | Capsaicin | small molecule | DB06774 | Details | |||
D460 | Chenodeoxycholic acid | small molecule | DB06777 | Details | |||
D461 | Cupric sulfate | small molecule | DB06778 | Details | |||
D462 | Lanreotide | small molecule | DB06791 | Details | |||
D463 | Plerixafor | small molecule | DB06809 | Details | |||
D464 | Phenylbutyric acid | small molecule | DB06819 | Details | |||
D465 | 4,4'-PROPANE-2,2-DIYLDIPHENOL | small molecule | DB06973 | Details | |||
D466 | Emodin | small molecule | DB07715 | Details | |||
D467 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | small molecule | DB07919 | Details | |||
D468 | Parecoxib | small molecule | DB08439 | Details | |||
D469 | Triclosan | small molecule | DB08604 | Details | |||
D470 | Nandrolone decanoate | small molecule | DB08804 | Details | |||
D471 | Ticagrelor | small molecule | DB08816 | Details | |||
D472 | Deferiprone | small molecule | DB08826 | Details | |||
D473 | Uric acid | small molecule | DB08844 | Details | |||
D474 | Pitavastatin | small molecule | DB08860 | Details | |||
D475 | Rilpivirine | small molecule | DB08864 | Details | |||
D476 | Linaclotide | small molecule | DB08890 | Details | |||
D477 | Tofacitinib | small molecule | DB08895 | Details | |||
D478 | Dimethyl fumarate | small molecule | DB08908 | Details | |||
D479 | Sofosbuvir | small molecule | DB08934 | Details | |||
D480 | Dexetimide | small molecule | DB08997 | Details | |||
D481 | Bisacodyl | small molecule | DB09020 | Details | |||
D482 | Aliskiren | small molecule | DB09026 | Details | |||
D483 | Ledipasvir | small molecule | DB09027 | Details | |||
D484 | Acipimox | small molecule | DB09055 | Details | |||
D485 | Ciprofibrate | small molecule | DB09064 | Details | |||
D486 | Olaparib | small molecule | DB09074 | Details | |||
D487 | Benzoyl peroxide | small molecule | DB09096 | Details | |||
D488 | Coenzyme M | small molecule | DB09110 | Details | |||
D489 | Nicorandil | small molecule | DB09220 | Details | |||
D490 | Manidipine | small molecule | DB09238 | Details | |||
D491 | Methylene blue | small molecule | DB09241 | Details | |||
D492 | Moxonidine | small molecule | DB09242 | Details | |||
D493 | Ubidecarenone | small molecule | DB09270 | Details | |||
D494 | Silibinin | small molecule | DB09298 | Details | |||
D495 | Glycerin | small molecule | DB09462 | Details | |||
D496 | Methyl salicylate | small molecule | DB09543 | Details | |||
D497 | Ixazomib | small molecule | DB09570 | Details | |||
D498 | Hydrogen peroxide | small molecule | DB11091 | Details | |||
D499 | Lycopene | small molecule | DB11231 | Details | |||
D500 | Medetomidine | small molecule | DB11428 | Details | |||
D501 | Lesinurad | small molecule | DB11560 | Details | |||
D502 | Carbon monoxide | small molecule | DB11588 | Details | |||
D503 | Curcumin | small molecule | DB11672 | Details | |||
D504 | Pyridoxamine | small molecule | DB11673 | Details | |||
D505 | Equol | small molecule | DB11674 | Details | |||
D506 | Mosapride | small molecule | DB11675 | Details | |||
D507 | Ebastine | small molecule | DB11742 | Details | |||
D508 | Rifamycin | small molecule | DB11753 | Details | |||
D509 | Imidapril | small molecule | DB11783 | Details | |||
D510 | Angiotensin II | small molecule | DB11842 | Details | |||
D511 | Verinurad | small molecule | DB11873 | Details | |||
D512 | 2,4-thiazolidinedione | small molecule | DB11898 | Details | |||
D513 | Zuretinol acetate | small molecule | DB12112 | Details | |||
D514 | Bradykinin | small molecule | DB12126 | Details | |||
D515 | Sarpogrelate | small molecule | DB12163 | Details | |||
D516 | Secoisolariciresinol | small molecule | DB12179 | Details | |||
D517 | Bexagliflozin | small molecule | DB12236 | Details | |||
D518 | Benzbromarone | small molecule | DB12319 | Details | |||
D519 | Nitroaspirin | small molecule | DB12445 | Details | |||
D520 | Piperine | small molecule | DB12582 | Details | |||
D521 | Isoquercetin | small molecule | DB12665 | Details | |||
D522 | Cicletanine | small molecule | DB12766 | Details | |||
D523 | Gallopamil | small molecule | DB12923 | Details | |||
D524 | Lactitol | small molecule | DB12942 | Details | |||
D525 | Daidzein | small molecule | DB13182 | Details | |||
D526 | Camostat | small molecule | DB13729 | Details | |||
D527 | Fenofibric acid | small molecule | DB13873 | Details | |||
D528 | Candesartan | small molecule | DB13919 | Details | |||
D529 | Testosterone enanthate | small molecule | DB13944 | Details | |||
D530 | Ferric cation | small molecule | DB13949 | Details | |||
D531 | Palmidrol | small molecule | DB14043 | Details | |||
D532 | Cianidanol | small molecule | DB14086 | Details | |||
D533 | Tenofovir | small molecule | DB14126 | Details | |||
D534 | Cinnamaldehyde | small molecule | DB14184 | Details | |||
D535 | Cobaltous cation | small molecule | DB14205 | Details | |||
D536 | Chromic cation | small molecule | DB14525 | Details | |||
D537 | Zinc cation | small molecule | DB14532 | Details | |||
D538 | Cupric cation | small molecule | DB14552 | Details | |||
D539 | Bismuth cation | small molecule | DB14572 | Details | |||
D540 | Calcium cation | small molecule | DB14577 | Details | |||
D541 | Cortisone | small molecule | DB14681 | Details | |||
D542 | Dabigatran | small molecule | DB14726 | Details | |||
D543 | Remdesivir | small molecule | DB14761 | Details | |||
D544 | Venglustat | small molecule | DB14966 | Details | |||
D545 | Abrocitinib | small molecule | DB14973 | Details | |||
D546 | Ursolic acid | small molecule | DB15588 | Details |