Research Articles
Research articles concerning CKD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in CKDdb are presented with knowledge graphs.
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Insulin receptor23 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00005 | 10480624 | Diabetes | A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. | 1999 | Details |
| A00006 | 10525667 | Diabetologia | Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. | 1999 | Details |
| A00019 | 11030756 | Hum Mol Genet | Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. | 2000 | Details |
| A00026 | 11473060 | Diabetes | New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes. | 2001 | Details |
| A00029 | 11600548 | J Clin Endocrinol Metab | The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion. | 2001 | Details |
| A00031 | 11739459 | J Clin Endocrinol Metab | The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. | 2001 | Details |
| A00044 | 12679424 | J Clin Endocrinol Metab | A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. | 2003 | Details |
| A00053 | 1314826 | J Biol Chem | Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action. | 1992 | Details |
| A00057 | 14671192 | J Clin Endocrinol Metab | Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. | 2004 | Details |
| A00064 | 15126519 | J Clin Endocrinol Metab | The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. | 2004 | Details |
| A00065 | 15166380 | Science | A family with severe insulin resistance and diabetes due to a mutation in AKT2. | 2004 | Details |
| A00070 | 15924147 | Nat Med | Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. | 2005 | Details |
| A00075 | 1607076 | Diabetes | NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene. | 1992 | Details |
| A00105 | 17906635 | Nat Med | Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | 2007 | Details |
| A00117 | 1890161 | J Clin Endocrinol Metab | A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. | 1991 | Details |
| A00121 | 19164855 | J Clin Invest | Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. | 2009 | Details |
| A00123 | 1963473 | Mol Endocrinol | Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor. | 1991 | Details |
| A00138 | 21364139 | JAMA | Functional variants of the HMGA1 gene and type 2 diabetes mellitus. | 2011 | Details |
| A00158 | 26150605 | J Am Soc Nephrol | The PROPKD Score: A New Algorithm to Predict Renal Survival in Autosomal Dominant Polycystic Kidney Disease. | 2016 | Details |
| A00186 | 32939031 | Genet Med | Clinical impact of genomic testing in patients with suspected monogenic kidney disease. | 2021 | Details |
| A00190 | 33434175 | Endocrinol Diabetes Metab Case Rep | A novel splice-site mutation of the HNF1B gene in a family with maturity onset diabetes of the young type 5 (MODY5). | 2024 | Details |
| A00195 | 39684653 | Int J Mol Sci | Pharmacological Nephroprotection in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus-Clinical Practice Position Statement of the Polish Society of Nephrology. | 2024 | Details |
| A00196 | 39704168 | JCI Insight | Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes. | 2024 | Details |