Research Article Details
Article ID: | A00006 |
PMID: | 10525667 |
Source: | Diabetologia |
Title: | Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. |
Abstract: | The aim of this study was to screen part of the putative promoter sequence in addition to 14 potential phosphotyrosine residues of human IRS-2 for genetic variability which might cause changes in protein expression or function. Furthermore, the potential impact on insulin secretion and sensitivity of a previously identified IRS-2 variant (Gly1057Asp) was analysed. The screenings were carried out by the SSCP-heteroduplex technique on DNA from Type II (non-insulin-dependent) diabetic patients. The impact of the Gly1057Asp variant was analysed in four glucose-tolerant Scandinavian study groups. The results showed no nucleotide substitutions in the promoter sequence, however, a novel heterozygous amino acid variant was identified (Leu647Val). In an association study, the new variant was found in 3 of 413 diabetic patients and in none of 280 glucose tolerant subjects. The variant did not affect the binding of IRS-2 to the insulin receptor or p85alpha of phosphatidylinositol 3-kinase when measured in the yeast two-hybrid system. Examination of the common Gly1057Asp variant in 363 young healthy subjects and in 228 glucose tolerant offspring of one diabetic parent showed no differences in insulin secretion or insulin sensitivity after an intravenous glucose tolerance test. Glucose tolerant middle-aged subjects homozygous for the polymorphism (n = 31), however, had on average a 25 % decrease in fasting serum insulin concentrations (p = 0.009) and 28 % (p = 0.01) and 34 % (p = 0.003) reductions in serum insulin concentrations at 30 and 60 min, respectively, during an OGTT compared with wildtype carriers (n = 107). In a cohort of 639 elderly Swedish men the amino acid variant did not have any detectable impact on insulin secretion after an OGTT. No genetic variability was found in the IRS-2 promoter. A rare IRS-2 variant at codon 647 has been identified in Type II diabetic patients. The prevalent codon 1057 polymorphism had no consistent effect on insulin secretion or insulin sensitivity. [Diabetologia (1999) 42: 1244-1249] |
DOI: | 10.1007/s001250051299 |

Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
---|
Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
---|---|---|---|---|---|---|---|
T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
T03 | Angiotensin-converting enzyme | ACE | INHIBITOR | Target is a single protein chain | P12821 | ACE_HUMAN | Details |
T06 | Sulfonylurea receptor 1 | ABCC8 | Target is a single protein chain | Q09428 | ABCC8_HUMAN | Details | |
T47 | Sialin | SLC17A5 | Target is a single protein chain | Q9NRA2 | SLC17A5_HUMAN | Details |
Diseases ID | DO ID | Disease Name | Definition | Class | |
---|---|---|---|---|---|
I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |
Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
---|---|---|---|---|---|---|---|
D001 | Leuprolide | small molecule | DB00007 | Details | |||
D002 | Goserelin | small molecule | DB00014 | Details | |||
D003 | Cetrorelix | small molecule | DB00050 | Details | |||
D004 | Pyridoxal phosphate | small molecule | DB00114 | Details | |||
D005 | Histidine | small molecule | DB00117 | Details | |||
D006 | Phenylalanine | small molecule | DB00120 | Details | |||
D007 | Biotin | small molecule | DB00121 | Details | |||
D008 | Choline | small molecule | DB00122 | Details | |||
D009 | L-Lysine | small molecule | DB00123 | Details | |||
D010 | Arginine | small molecule | DB00125 | Details | |||
D011 | Ascorbic acid | small molecule | DB00126 | Details | |||
D012 | Aspartic acid | small molecule | DB00128 | Details | |||
D013 | Ornithine | small molecule | DB00129 | Details | |||
D014 | L-Glutamine | small molecule | DB00130 | Details | |||
D015 | Serine | small molecule | DB00133 | Details | |||
D016 | Methionine | small molecule | DB00134 | Details | |||
D017 | Tyrosine | small molecule | DB00135 | Details | |||
D018 | Calcitriol | small molecule | DB00136 | Details | |||
D019 | Lutein | small molecule | DB00137 | Details | |||
D020 | Riboflavin | small molecule | DB00140 | Details | |||
D021 | Glutamic acid | small molecule | DB00142 | Details | |||
D022 | Phosphatidyl serine | small molecule | DB00144 | Details | |||
D023 | Glycine | small molecule | DB00145 | Details | |||
D024 | Calcifediol | small molecule | DB00146 | Details | |||
D025 | Pyridoxal | small molecule | DB00147 | Details | |||
D026 | Creatine | small molecule | DB00148 | Details | |||
D027 | Leucine | small molecule | DB00149 | Details | |||
D028 | Tryptophan | small molecule | DB00150 | Details | |||
D029 | Cysteine | small molecule | DB00151 | Details | |||
D030 | Thiamine | small molecule | DB00152 | Details | |||
D031 | Ergocalciferol | small molecule | DB00153 | Details | |||
D032 | Threonine | small molecule | DB00156 | Details | |||
D033 | Alanine | small molecule | DB00160 | Details | |||
D034 | Valine | small molecule | DB00161 | Details | |||
D035 | Vitamin A | small molecule | DB00162 | Details | |||
D036 | Vitamin E | small molecule | DB00163 | Details | |||
D037 | Pyridoxine | small molecule | DB00165 | Details | |||
D038 | Isoleucine | small molecule | DB00167 | Details | |||
D039 | Cholecalciferol | small molecule | DB00169 | Details | |||
D040 | Menadione | small molecule | DB00170 | Details | |||
D041 | Proline | small molecule | DB00172 | Details | |||
D042 | Pravastatin | small molecule | DB00175 | Details | |||
D043 | Valsartan | small molecule | DB00177 | Details | |||
D044 | Ramipril | small molecule | DB00178 | Details | |||
D045 | Esmolol | small molecule | DB00187 | Details | |||
D046 | Bortezomib | small molecule | DB00188 | Details | |||
D047 | Phentermine | small molecule | DB00191 | Details | |||
D048 | Tramadol | small molecule | DB00193 | Details | |||
D049 | Fluconazole | small molecule | DB00196 | Details | |||
D050 | Troglitazone | small molecule | DB00197 | Details | |||
D051 | Oseltamivir | small molecule | DB00198 | Details | |||
D052 | Erythromycin | small molecule | DB00199 | Details | |||
D053 | Caffeine | small molecule | DB00201 | Details | |||
D054 | Reserpine | small molecule | DB00206 | Details | |||
D055 | Azithromycin | small molecule | DB00207 | Details | |||
D056 | Pantoprazole | small molecule | DB00213 | Details | |||
D057 | Torasemide | small molecule | DB00214 | Details | |||
D058 | Citalopram | small molecule | DB00215 | Details | |||
D059 | Moxifloxacin | small molecule | DB00218 | Details | |||
D060 | Indinavir | small molecule | DB00224 | Details | |||
D061 | Lovastatin | small molecule | DB00227 | Details | |||
D062 | Pregabalin | small molecule | DB00230 | Details | |||
D063 | Nevirapine | small molecule | DB00238 | Details | |||
D064 | Ranolazine | small molecule | DB00243 | Details | |||
D065 | Ziprasidone | small molecule | DB00246 | Details | |||
D066 | Doxycycline | small molecule | DB00254 | Details | |||
D067 | Clotrimazole | small molecule | DB00257 | Details | |||
D068 | Metoprolol | small molecule | DB00264 | Details | |||
D069 | Ropinirole | small molecule | DB00268 | Details | |||
D070 | Chlorotrianisene | small molecule | DB00269 | Details | |||
D071 | Topiramate | small molecule | DB00273 | Details | |||
D072 | Olmesartan | small molecule | DB00275 | Details | |||
D073 | Theophylline | small molecule | DB00277 | Details | |||
D074 | Lidocaine | small molecule | DB00281 | Details | |||
D075 | Pamidronic acid | small molecule | DB00282 | Details | |||
D076 | Chlorambucil | small molecule | DB00291 | Details | |||
D077 | Morphine | small molecule | DB00295 | Details | |||
D078 | Bupivacaine | small molecule | DB00297 | Details | |||
D079 | Tranexamic acid | small molecule | DB00302 | Details | |||
D080 | Ertapenem | small molecule | DB00303 | Details | |||
D081 | Mitomycin | small molecule | DB00305 | Details | |||
D082 | Chlorthalidone | small molecule | DB00310 | Details | |||
D083 | Valproic acid | small molecule | DB00313 | Details | |||
D084 | Acetaminophen | small molecule | DB00316 | Details | |||
D085 | Piperacillin | small molecule | DB00319 | Details | |||
D086 | Amitriptyline | small molecule | DB00321 | Details | |||
D087 | Nitroprusside | small molecule | DB00325 | Details | |||
D088 | Indomethacin | small molecule | DB00328 | Details | |||
D089 | Metformin | small molecule | DB00331 | Details | |||
D090 | Methadone | small molecule | DB00333 | Details | |||
D091 | Olanzapine | small molecule | DB00334 | Details | |||
D092 | Atenolol | small molecule | DB00335 | Details | |||
D093 | Cetirizine | small molecule | DB00341 | Details | |||
D094 | Diltiazem | small molecule | DB00343 | Details | |||
D095 | Minoxidil | small molecule | DB00350 | Details | |||
D096 | Chlorzoxazone | small molecule | DB00356 | Details | |||
D097 | Clozapine | small molecule | DB00363 | Details | |||
D098 | Levonorgestrel | small molecule | DB00367 | Details | |||
D099 | Norepinephrine | small molecule | DB00368 | Details | |||
D100 | Cidofovir | small molecule | DB00369 | Details | |||
D101 | Mirtazapine | small molecule | DB00370 | Details | |||
D102 | Treprostinil | small molecule | DB00374 | Details | |||
D103 | Dydrogesterone | small molecule | DB00378 | Details | |||
D104 | Amlodipine | small molecule | DB00381 | Details | |||
D105 | Triamterene | small molecule | DB00384 | Details | |||
D106 | Phenylephrine | small molecule | DB00388 | Details | |||
D107 | Digoxin | small molecule | DB00390 | Details | |||
D108 | Nimodipine | small molecule | DB00393 | Details | |||
D109 | Progesterone | small molecule | DB00396 | Details | |||
D110 | Sorafenib | small molecule | DB00398 | Details | |||
D111 | Zoledronic acid | small molecule | DB00399 | Details | |||
D112 | Eszopiclone | small molecule | DB00402 | Details | |||
D113 | Alprazolam | small molecule | DB00404 | Details | |||
D114 | Loxapine | small molecule | DB00408 | Details | |||
D115 | Mupirocin | small molecule | DB00410 | Details | |||
D116 | Rosiglitazone | small molecule | DB00412 | Details | |||
D117 | Acetohexamide | small molecule | DB00414 | Details | |||
D118 | Ampicillin | small molecule | DB00415 | Details | |||
D119 | Spironolactone | small molecule | DB00421 | Details | |||
D120 | Methocarbamol | small molecule | DB00423 | Details | |||
D121 | Zolpidem | small molecule | DB00425 | Details | |||
D122 | Nitric Oxide | small molecule | DB00435 | Details | |||
D123 | Ceftazidime | small molecule | DB00438 | Details | |||
D124 | Trimethoprim | small molecule | DB00440 | Details | |||
D125 | Betamethasone | small molecule | DB00443 | Details | |||
D126 | Lansoprazole | small molecule | DB00448 | Details | |||
D127 | Loratadine | small molecule | DB00455 | Details | |||
D128 | Imipramine | small molecule | DB00458 | Details | |||
D129 | Dronabinol | small molecule | DB00470 | Details | |||
D130 | Montelukast | small molecule | DB00471 | Details | |||
D131 | Fluoxetine | small molecule | DB00472 | Details | |||
D132 | Duloxetine | small molecule | DB00476 | Details | |||
D133 | Chlorpromazine | small molecule | DB00477 | Details | |||
D134 | Amikacin | small molecule | DB00479 | Details | |||
D135 | Lenalidomide | small molecule | DB00480 | Details | |||
D136 | Celecoxib | small molecule | DB00482 | Details | |||
D137 | Altretamine | small molecule | DB00488 | Details | |||
D138 | Miglitol | small molecule | DB00491 | Details | |||
D139 | Cefotaxime | small molecule | DB00493 | Details | |||
D140 | Zidovudine | small molecule | DB00495 | Details | |||
D141 | Oxycodone | small molecule | DB00497 | Details | |||
D142 | Cimetidine | small molecule | DB00501 | Details | |||
D143 | Ritonavir | small molecule | DB00503 | Details | |||
D144 | Nitazoxanide | small molecule | DB00507 | Details | |||
D145 | Vancomycin | small molecule | DB00512 | Details | |||
D146 | Aminocaproic acid | small molecule | DB00513 | Details | |||
D147 | Trandolapril | small molecule | DB00519 | Details | |||
D148 | Metolazone | small molecule | DB00524 | Details | |||
D149 | Tolnaftate | small molecule | DB00525 | Details | |||
D150 | Lercanidipine | small molecule | DB00528 | Details | |||
D151 | Cyclophosphamide | small molecule | DB00531 | Details | |||
D152 | Ciprofloxacin | small molecule | DB00537 | Details | |||
D153 | Benazepril | small molecule | DB00542 | Details | |||
D154 | Propylthiouracil | small molecule | DB00550 | Details | |||
D155 | Zanamivir | small molecule | DB00558 | Details | |||
D156 | Bosentan | small molecule | DB00559 | Details | |||
D157 | Methotrexate | small molecule | DB00563 | Details | |||
D158 | Cisatracurium | small molecule | DB00565 | Details | |||
D159 | Cephalexin | small molecule | DB00567 | Details | |||
D160 | Propranolol | small molecule | DB00571 | Details | |||
D161 | Atropine | small molecule | DB00572 | Details | |||
D162 | Clonidine | small molecule | DB00575 | Details | |||
D163 | Lactulose | small molecule | DB00581 | Details | |||
D164 | Voriconazole | small molecule | DB00582 | Details | |||
D165 | Diclofenac | small molecule | DB00586 | Details | |||
D166 | Doxazosin | small molecule | DB00590 | Details | |||
D167 | Amiloride | small molecule | DB00594 | Details | |||
D168 | Labetalol | small molecule | DB00598 | Details | |||
D169 | Thiopental | small molecule | DB00599 | Details | |||
D170 | Linezolid | small molecule | DB00601 | Details | |||
D171 | Cisapride | small molecule | DB00604 | Details | |||
D172 | Nafcillin | small molecule | DB00607 | Details | |||
D173 | Chloroquine | small molecule | DB00608 | Details | |||
D174 | Bisoprolol | small molecule | DB00612 | Details | |||
D175 | Fluphenazine | small molecule | DB00623 | Details | |||
D176 | Testosterone | small molecule | DB00624 | Details | |||
D177 | Efavirenz | small molecule | DB00625 | Details | |||
D178 | Bacitracin | small molecule | DB00626 | Details | |||
D179 | Niacin | small molecule | DB00627 | Details | |||
D180 | Alendronic acid | small molecule | DB00630 | Details | |||
D181 | Prednisone | small molecule | DB00635 | Details | |||
D182 | Inulin | small molecule | DB00638 | Details | |||
D183 | Adenosine | small molecule | DB00640 | Details | |||
D184 | Simvastatin | small molecule | DB00641 | Details | |||
D185 | Stavudine | small molecule | DB00649 | Details | |||
D186 | Trazodone | small molecule | DB00656 | Details | |||
D187 | Verapamil | small molecule | DB00661 | Details | |||
D188 | Epinephrine | small molecule | DB00668 | Details | |||
D189 | Pirenzepine | small molecule | DB00670 | Details | |||
D190 | Cefixime | small molecule | DB00671 | Details | |||
D191 | Chlorpropamide | small molecule | DB00672 | Details | |||
D192 | Losartan | small molecule | DB00678 | Details | |||
D193 | Thioridazine | small molecule | DB00679 | Details | |||
D194 | Warfarin | small molecule | DB00682 | Details | |||
D195 | Midazolam | small molecule | DB00683 | Details | |||
D196 | Tobramycin | small molecule | DB00684 | Details | |||
D197 | Fludrocortisone | small molecule | DB00687 | Details | |||
D198 | Phentolamine | small molecule | DB00692 | Details | |||
D199 | Furosemide | small molecule | DB00695 | Details | |||
D200 | Eplerenone | small molecule | DB00700 | Details | |||
D201 | Amprenavir | small molecule | DB00701 | Details | |||
D202 | Naltrexone | small molecule | DB00704 | Details | |||
D203 | Tamsulosin | small molecule | DB00706 | Details | |||
D204 | Lamivudine | small molecule | DB00709 | Details | |||
D205 | Ibandronate | small molecule | DB00710 | Details | |||
D206 | Flurbiprofen | small molecule | DB00712 | Details | |||
D207 | Oxacillin | small molecule | DB00713 | Details | |||
D208 | Paroxetine | small molecule | DB00715 | Details | |||
D209 | Lisinopril | small molecule | DB00722 | Details | |||
D210 | Nitroglycerin | small molecule | DB00727 | Details | |||
D211 | Rocuronium | small molecule | DB00728 | Details | |||
D212 | Risperidone | small molecule | DB00734 | Details | |||
D213 | Esomeprazole | small molecule | DB00736 | Details | |||
D214 | Pentamidine | small molecule | DB00738 | Details | |||
D215 | Hydrocortisone | small molecule | DB00741 | Details | |||
D216 | Mannitol | small molecule | DB00742 | Details | |||
D217 | Deferoxamine | small molecule | DB00746 | Details | |||
D218 | Prilocaine | small molecule | DB00750 | Details | |||
D219 | Isoflurane | small molecule | DB00753 | Details | |||
D220 | Clopidogrel | small molecule | DB00758 | Details | |||
D221 | Methimazole | small molecule | DB00763 | Details | |||
D222 | Clavulanic acid | small molecule | DB00766 | Details | |||
D223 | Alprostadil | small molecule | DB00770 | Details | |||
D224 | Mefenamic acid | small molecule | DB00784 | Details | |||
D225 | Perindopril | small molecule | DB00790 | Details | |||
D226 | Alfentanil | small molecule | DB00802 | Details | |||
D227 | Pentoxifylline | small molecule | DB00806 | Details | |||
D228 | Indapamide | small molecule | DB00808 | Details | |||
D229 | Tropicamide | small molecule | DB00809 | Details | |||
D230 | Ribavirin | small molecule | DB00811 | Details | |||
D231 | Fentanyl | small molecule | DB00813 | Details | |||
D232 | Propofol | small molecule | DB00818 | Details | |||
D233 | Acetazolamide | small molecule | DB00819 | Details | |||
D234 | Tadalafil | small molecule | DB00820 | Details | |||
D235 | Fosfomycin | small molecule | DB00828 | Details | |||
D236 | Diazepam | small molecule | DB00829 | Details | |||
D237 | Trifluoperazine | small molecule | DB00831 | Details | |||
D238 | Mifepristone | small molecule | DB00834 | Details | |||
D239 | Tolazamide | small molecule | DB00839 | Details | |||
D240 | Dobutamine | small molecule | DB00841 | Details | |||
D241 | Donepezil | small molecule | DB00843 | Details | |||
D242 | Nalbuphine | small molecule | DB00844 | Details | |||
D243 | Levamisole | small molecule | DB00848 | Details | |||
D244 | Perphenazine | small molecule | DB00850 | Details | |||
D245 | Pseudoephedrine | small molecule | DB00852 | Details | |||
D246 | Aminolevulinic acid | small molecule | DB00855 | Details | |||
D247 | Terbinafine | small molecule | DB00857 | Details | |||
D248 | Prednisolone | small molecule | DB00860 | Details | |||
D249 | Diflunisal | small molecule | DB00861 | Details | |||
D250 | Terbutaline | small molecule | DB00871 | Details | |||
D251 | Guaifenesin | small molecule | DB00874 | Details | |||
D252 | Eprosartan | small molecule | DB00876 | Details | |||
D253 | Sirolimus | small molecule | DB00877 | Details | |||
D254 | Emtricitabine | small molecule | DB00879 | Details | |||
D255 | Quinapril | small molecule | DB00881 | Details | |||
D256 | Isosorbide dinitrate | small molecule | DB00883 | Details | |||
D257 | Mechlorethamine | small molecule | DB00888 | Details | |||
D258 | Ethanol | small molecule | DB00898 | Details | |||
D259 | Remifentanil | small molecule | DB00899 | Details | |||
D260 | Ondansetron | small molecule | DB00904 | Details | |||
D261 | Cocaine | small molecule | DB00907 | Details | |||
D262 | Repaglinide | small molecule | DB00912 | Details | |||
D263 | Phenformin | small molecule | DB00914 | Details | |||
D264 | Amantadine | small molecule | DB00915 | Details | |||
D265 | Metronidazole | small molecule | DB00916 | Details | |||
D266 | Dinoprostone | small molecule | DB00917 | Details | |||
D267 | Buprenorphine | small molecule | DB00921 | Details | |||
D268 | Azacitidine | small molecule | DB00928 | Details | |||
D269 | Misoprostol | small molecule | DB00929 | Details | |||
D270 | Mesoridazine | small molecule | DB00933 | Details | |||
D271 | Oxymetazoline | small molecule | DB00935 | Details | |||
D272 | Salicylic acid | small molecule | DB00936 | Details | |||
D273 | Acetylsalicylic acid | small molecule | DB00945 | Details | |||
D274 | Phenprocoumon | small molecule | DB00946 | Details | |||
D275 | Fexofenadine | small molecule | DB00950 | Details | |||
D276 | Isoniazid | small molecule | DB00951 | Details | |||
D277 | Norgestimate | small molecule | DB00957 | Details | |||
D278 | Methylprednisolone | small molecule | DB00959 | Details | |||
D279 | Mepivacaine | small molecule | DB00961 | Details | |||
D280 | Zaleplon | small molecule | DB00962 | Details | |||
D281 | Bromfenac | small molecule | DB00963 | Details | |||
D282 | Telmisartan | small molecule | DB00966 | Details | |||
D283 | Methyldopa | small molecule | DB00968 | Details | |||
D284 | Ezetimibe | small molecule | DB00973 | Details | |||
D285 | Edetic acid | small molecule | DB00974 | Details | |||
D286 | Dipyridamole | small molecule | DB00975 | Details | |||
D287 | Ethinylestradiol | small molecule | DB00977 | Details | |||
D288 | Physostigmine | small molecule | DB00981 | Details | |||
D289 | Isotretinoin | small molecule | DB00982 | Details | |||
D290 | Nandrolone phenpropionate | small molecule | DB00984 | Details | |||
D291 | Glycopyrronium | small molecule | DB00986 | Details | |||
D292 | Dopamine | small molecule | DB00988 | Details | |||
D293 | Azathioprine | small molecule | DB00993 | Details | |||
D294 | Gabapentin | small molecule | DB00996 | Details | |||
D295 | Frovatriptan | small molecule | DB00998 | Details | |||
D296 | Hydrochlorothiazide | small molecule | DB00999 | Details | |||
D297 | Salbutamol | small molecule | DB01001 | Details | |||
D298 | Levobupivacaine | small molecule | DB01002 | Details | |||
D299 | Hydroxyurea | small molecule | DB01005 | Details | |||
D300 | Letrozole | small molecule | DB01006 | Details | |||
D301 | Metyrapone | small molecule | DB01011 | Details | |||
D302 | Cinacalcet | small molecule | DB01012 | Details | |||
D303 | Sulfamethoxazole | small molecule | DB01015 | Details | |||
D304 | Bethanechol | small molecule | DB01019 | Details | |||
D305 | Phylloquinone | small molecule | DB01022 | Details | |||
D306 | Felodipine | small molecule | DB01023 | Details | |||
D307 | Mycophenolic acid | small molecule | DB01024 | Details | |||
D308 | Amlexanox | small molecule | DB01025 | Details | |||
D309 | Irbesartan | small molecule | DB01029 | Details | |||
D310 | Probenecid | small molecule | DB01032 | Details | |||
D311 | Fenofibrate | small molecule | DB01039 | Details | |||
D312 | Thalidomide | small molecule | DB01041 | Details | |||
D313 | Ibuprofen | small molecule | DB01050 | Details | |||
D314 | Benzylpenicillin | small molecule | DB01053 | Details | |||
D315 | Amoxicillin | small molecule | DB01060 | Details | |||
D316 | Melatonin | small molecule | DB01065 | Details | |||
D317 | Glipizide | small molecule | DB01067 | Details | |||
D318 | Promethazine | small molecule | DB01069 | Details | |||
D319 | Diphenhydramine | small molecule | DB01075 | Details | |||
D320 | Atorvastatin | small molecule | DB01076 | Details | |||
D321 | Vigabatrin | small molecule | DB01080 | Details | |||
D322 | Streptomycin | small molecule | DB01082 | Details | |||
D323 | Orlistat | small molecule | DB01083 | Details | |||
D324 | Pilocarpine | small molecule | DB01085 | Details | |||
D325 | Benzocaine | small molecule | DB01086 | Details | |||
D326 | Dimethyl sulfoxide | small molecule | DB01093 | Details | |||
D327 | Pimozide | small molecule | DB01100 | Details | |||
D328 | Sertraline | small molecule | DB01104 | Details | |||
D329 | Miconazole | small molecule | DB01110 | Details | |||
D330 | Nifedipine | small molecule | DB01115 | Details | |||
D331 | Amiodarone | small molecule | DB01118 | Details | |||
D332 | Diazoxide | small molecule | DB01119 | Details | |||
D333 | Gliclazide | small molecule | DB01120 | Details | |||
D334 | Tolbutamide | small molecule | DB01124 | Details | |||
D335 | Dutasteride | small molecule | DB01126 | Details | |||
D336 | Pioglitazone | small molecule | DB01132 | Details | |||
D337 | Carvedilol | small molecule | DB01136 | Details | |||
D338 | Levofloxacin | small molecule | DB01137 | Details | |||
D339 | Cefadroxil | small molecule | DB01140 | Details | |||
D340 | Bupropion | small molecule | DB01156 | Details | |||
D341 | Terazosin | small molecule | DB01162 | Details | |||
D342 | Ofloxacin | small molecule | DB01165 | Details | |||
D343 | Cilostazol | small molecule | DB01166 | Details | |||
D344 | Itraconazole | small molecule | DB01167 | Details | |||
D345 | Chlormezanone | small molecule | DB01178 | Details | |||
D346 | Naloxone | small molecule | DB01183 | Details | |||
D347 | Domperidone | small molecule | DB01184 | Details | |||
D348 | Ciclopirox | small molecule | DB01188 | Details | |||
D349 | Desflurane | small molecule | DB01189 | Details | |||
D350 | Clindamycin | small molecule | DB01190 | Details | |||
D351 | Dexfenfluramine | small molecule | DB01191 | Details | |||
D352 | Captopril | small molecule | DB01197 | Details | |||
D353 | Zopiclone | small molecule | DB01198 | Details | |||
D354 | Bromocriptine | small molecule | DB01200 | Details | |||
D355 | Clarithromycin | small molecule | DB01211 | Details | |||
D356 | Ceftriaxone | small molecule | DB01212 | Details | |||
D357 | Anastrozole | small molecule | DB01217 | Details | |||
D358 | Dantrolene | small molecule | DB01219 | Details | |||
D359 | Budesonide | small molecule | DB01222 | Details | |||
D360 | Quetiapine | small molecule | DB01224 | Details | |||
D361 | Paclitaxel | small molecule | DB01229 | Details | |||
D362 | Metoclopramide | small molecule | DB01233 | Details | |||
D363 | Dexamethasone | small molecule | DB01234 | Details | |||
D364 | Sevoflurane | small molecule | DB01236 | Details | |||
D365 | Aripiprazole | small molecule | DB01238 | Details | |||
D366 | Epoprostenol | small molecule | DB01240 | Details | |||
D367 | Gliquidone | small molecule | DB01251 | Details | |||
D368 | Dasatinib | small molecule | DB01254 | Details | |||
D369 | Lapatinib | small molecule | DB01259 | Details | |||
D370 | Darunavir | small molecule | DB01264 | Details | |||
D371 | Sunitinib | small molecule | DB01268 | Details | |||
D372 | Hydralazine | small molecule | DB01275 | Details | |||
D373 | Lumiracoxib | small molecule | DB01283 | Details | |||
D374 | Glucosamine | small molecule | DB01296 | Details | |||
D375 | Cefazolin | small molecule | DB01327 | Details | |||
D376 | Vecuronium | small molecule | DB01339 | Details | |||
D377 | Cilazapril | small molecule | DB01340 | Details | |||
D378 | Spirapril | small molecule | DB01348 | Details | |||
D379 | Ephedrine | small molecule | DB01364 | Details | |||
D380 | Yohimbine | small molecule | DB01392 | Details | |||
D381 | Bezafibrate | small molecule | DB01393 | Details | |||
D382 | Colchicine | small molecule | DB01394 | Details | |||
D383 | Drospirenone | small molecule | DB01395 | Details | |||
D384 | Methotrimeprazine | small molecule | DB01403 | Details | |||
D385 | Clenbuterol | small molecule | DB01407 | Details | |||
D386 | Theobromine | small molecule | DB01412 | Details | |||
D387 | Cefepime | small molecule | DB01413 | Details | |||
D388 | Alfacalcidol | small molecule | DB01436 | Details | |||
D389 | Diamorphine | small molecule | DB01452 | Details | |||
D390 | Metamfetamine | small molecule | DB01577 | Details | |||
D391 | Sulfamethazine | small molecule | DB01582 | Details | |||
D392 | Ursodeoxycholic acid | small molecule | DB01586 | Details | |||
D393 | Probucol | small molecule | DB01599 | Details | |||
D394 | Lopinavir | small molecule | DB01601 | Details | |||
D395 | Tazobactam | small molecule | DB01606 | Details | |||
D396 | Hydroxychloroquine | small molecule | DB01611 | Details | |||
D397 | Molindone | small molecule | DB01618 | Details | |||
D398 | Thiothixene | small molecule | DB01623 | Details | |||
D399 | Sorbitol | small molecule | DB01638 | Details | |||
D400 | Genistein | small molecule | DB01645 | Details | |||
D401 | N,N-dimethylarginine | small molecule | DB01686 | Details | |||
D402 | Prasterone | small molecule | DB01708 | Details | |||
D403 | Pantothenic acid | small molecule | DB01783 | Details | |||
D404 | Taurine | small molecule | DB01956 | Details | |||
D405 | Calcipotriol | small molecule | DB02300 | Details | |||
D406 | Thymol | small molecule | DB02513 | Details | |||
D407 | gamma-Aminobutyric acid | small molecule | DB02530 | Details | |||
D408 | Terlipressin | small molecule | DB02638 | Details | |||
D409 | Nicotinamide | small molecule | DB02701 | Details | |||
D410 | Fusidic acid | small molecule | DB02703 | Details | |||
D411 | Resveratrol | small molecule | DB02709 | Details | |||
D412 | Oxitriptan | small molecule | DB02959 | Details | |||
D413 | Glycolic acid | small molecule | DB03085 | Details | |||
D414 | Acetylcholine | small molecule | DB03128 | Details | |||
D415 | Acetic acid | small molecule | DB03166 | Details | |||
D416 | Phenol | small molecule | DB03255 | Details | |||
D417 | Palmitic Acid | small molecule | DB03796 | Details | |||
D418 | Eucalyptol | small molecule | DB03852 | Details | |||
D419 | Citric acid | small molecule | DB04272 | Details | |||
D420 | Maleic Acid | small molecule | DB04299 | Details | |||
D421 | N,N,N-trimethylglycinium | small molecule | DB04455 | Details | |||
D422 | Meso-Erythritol | small molecule | DB04481 | Details | |||
D423 | Indole | small molecule | DB04532 | Details | |||
D424 | Arachidonic Acid | small molecule | DB04557 | Details | |||
D425 | Buformin | small molecule | DB04830 | Details | |||
D426 | Methaqualone | small molecule | DB04833 | Details | |||
D427 | Cyproterone acetate | small molecule | DB04839 | Details | |||
D428 | Fluspirilene | small molecule | DB04842 | Details | |||
D429 | Tetrabenazine | small molecule | DB04844 | Details | |||
D430 | Febuxostat | small molecule | DB04854 | Details | |||
D431 | Nebivolol | small molecule | DB04861 | Details | |||
D432 | Vildagliptin | small molecule | DB04876 | Details | |||
D433 | Voglibose | small molecule | DB04878 | Details | |||
D434 | Iloperidone | small molecule | DB04946 | Details | |||
D435 | Lobeline | small molecule | DB05137 | Details | |||
D436 | Histamine | small molecule | DB05381 | Details | |||
D437 | Iodine | small molecule | DB05382 | Details | |||
D438 | Levoketoconazole | small molecule | DB05667 | Details | |||
D439 | Acetylcysteine | small molecule | DB06151 | Details | |||
D440 | Atrasentan | small molecule | DB06199 | Details | |||
D441 | Rivaroxaban | small molecule | DB06228 | Details | |||
D442 | Eflornithine | small molecule | DB06243 | Details | |||
D443 | Sitaxentan | small molecule | DB06268 | Details | |||
D444 | Amisulpride | small molecule | DB06288 | Details | |||
D445 | Dapagliflozin | small molecule | DB06292 | Details | |||
D446 | Darapladib | small molecule | DB06311 | Details | |||
D447 | Saxagliptin | small molecule | DB06335 | Details | |||
D448 | Ambrisentan | small molecule | DB06403 | Details | |||
D449 | Etravirine | small molecule | DB06414 | Details | |||
D450 | Prucalopride | small molecule | DB06480 | Details | |||
D451 | Cetilistat | small molecule | DB06586 | Details | |||
D452 | Agomelatine | small molecule | DB06594 | Details | |||
D453 | Apixaban | small molecule | DB06605 | Details | |||
D454 | Bosutinib | small molecule | DB06616 | Details | |||
D455 | Desvenlafaxine | small molecule | DB06700 | Details | |||
D456 | Methyltestosterone | small molecule | DB06710 | Details | |||
D457 | Beta carotene | small molecule | DB06755 | Details | |||
D458 | Manganese | small molecule | DB06757 | Details | |||
D459 | Capsaicin | small molecule | DB06774 | Details | |||
D460 | Chenodeoxycholic acid | small molecule | DB06777 | Details | |||
D461 | Cupric sulfate | small molecule | DB06778 | Details | |||
D462 | Lanreotide | small molecule | DB06791 | Details | |||
D463 | Plerixafor | small molecule | DB06809 | Details | |||
D464 | Phenylbutyric acid | small molecule | DB06819 | Details | |||
D465 | 4,4'-PROPANE-2,2-DIYLDIPHENOL | small molecule | DB06973 | Details | |||
D466 | Emodin | small molecule | DB07715 | Details | |||
D467 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | small molecule | DB07919 | Details | |||
D468 | Parecoxib | small molecule | DB08439 | Details | |||
D469 | Triclosan | small molecule | DB08604 | Details | |||
D470 | Nandrolone decanoate | small molecule | DB08804 | Details | |||
D471 | Ticagrelor | small molecule | DB08816 | Details | |||
D472 | Deferiprone | small molecule | DB08826 | Details | |||
D473 | Uric acid | small molecule | DB08844 | Details | |||
D474 | Pitavastatin | small molecule | DB08860 | Details | |||
D475 | Rilpivirine | small molecule | DB08864 | Details | |||
D476 | Linaclotide | small molecule | DB08890 | Details | |||
D477 | Tofacitinib | small molecule | DB08895 | Details | |||
D478 | Dimethyl fumarate | small molecule | DB08908 | Details | |||
D479 | Sofosbuvir | small molecule | DB08934 | Details | |||
D480 | Dexetimide | small molecule | DB08997 | Details | |||
D481 | Bisacodyl | small molecule | DB09020 | Details | |||
D482 | Aliskiren | small molecule | DB09026 | Details | |||
D483 | Ledipasvir | small molecule | DB09027 | Details | |||
D484 | Acipimox | small molecule | DB09055 | Details | |||
D485 | Ciprofibrate | small molecule | DB09064 | Details | |||
D486 | Olaparib | small molecule | DB09074 | Details | |||
D487 | Benzoyl peroxide | small molecule | DB09096 | Details | |||
D488 | Coenzyme M | small molecule | DB09110 | Details | |||
D489 | Nicorandil | small molecule | DB09220 | Details | |||
D490 | Manidipine | small molecule | DB09238 | Details | |||
D491 | Methylene blue | small molecule | DB09241 | Details | |||
D492 | Moxonidine | small molecule | DB09242 | Details | |||
D493 | Ubidecarenone | small molecule | DB09270 | Details | |||
D494 | Silibinin | small molecule | DB09298 | Details | |||
D495 | Glycerin | small molecule | DB09462 | Details | |||
D496 | Methyl salicylate | small molecule | DB09543 | Details | |||
D497 | Ixazomib | small molecule | DB09570 | Details | |||
D498 | Hydrogen peroxide | small molecule | DB11091 | Details | |||
D499 | Lycopene | small molecule | DB11231 | Details | |||
D500 | Medetomidine | small molecule | DB11428 | Details | |||
D501 | Lesinurad | small molecule | DB11560 | Details | |||
D502 | Carbon monoxide | small molecule | DB11588 | Details | |||
D503 | Curcumin | small molecule | DB11672 | Details | |||
D504 | Pyridoxamine | small molecule | DB11673 | Details | |||
D505 | Equol | small molecule | DB11674 | Details | |||
D506 | Mosapride | small molecule | DB11675 | Details | |||
D507 | Ebastine | small molecule | DB11742 | Details | |||
D508 | Rifamycin | small molecule | DB11753 | Details | |||
D509 | Imidapril | small molecule | DB11783 | Details | |||
D510 | Angiotensin II | small molecule | DB11842 | Details | |||
D511 | Verinurad | small molecule | DB11873 | Details | |||
D512 | 2,4-thiazolidinedione | small molecule | DB11898 | Details | |||
D513 | Zuretinol acetate | small molecule | DB12112 | Details | |||
D514 | Bradykinin | small molecule | DB12126 | Details | |||
D515 | Sarpogrelate | small molecule | DB12163 | Details | |||
D516 | Secoisolariciresinol | small molecule | DB12179 | Details | |||
D517 | Bexagliflozin | small molecule | DB12236 | Details | |||
D518 | Benzbromarone | small molecule | DB12319 | Details | |||
D519 | Nitroaspirin | small molecule | DB12445 | Details | |||
D520 | Piperine | small molecule | DB12582 | Details | |||
D521 | Isoquercetin | small molecule | DB12665 | Details | |||
D522 | Cicletanine | small molecule | DB12766 | Details | |||
D523 | Gallopamil | small molecule | DB12923 | Details | |||
D524 | Lactitol | small molecule | DB12942 | Details | |||
D525 | Daidzein | small molecule | DB13182 | Details | |||
D526 | Camostat | small molecule | DB13729 | Details | |||
D527 | Fenofibric acid | small molecule | DB13873 | Details | |||
D528 | Candesartan | small molecule | DB13919 | Details | |||
D529 | Testosterone enanthate | small molecule | DB13944 | Details | |||
D530 | Ferric cation | small molecule | DB13949 | Details | |||
D531 | Palmidrol | small molecule | DB14043 | Details | |||
D532 | Cianidanol | small molecule | DB14086 | Details | |||
D533 | Tenofovir | small molecule | DB14126 | Details | |||
D534 | Cinnamaldehyde | small molecule | DB14184 | Details | |||
D535 | Cobaltous cation | small molecule | DB14205 | Details | |||
D536 | Chromic cation | small molecule | DB14525 | Details | |||
D537 | Zinc cation | small molecule | DB14532 | Details | |||
D538 | Cupric cation | small molecule | DB14552 | Details | |||
D539 | Bismuth cation | small molecule | DB14572 | Details | |||
D540 | Calcium cation | small molecule | DB14577 | Details | |||
D541 | Cortisone | small molecule | DB14681 | Details | |||
D542 | Dabigatran | small molecule | DB14726 | Details | |||
D543 | Remdesivir | small molecule | DB14761 | Details | |||
D544 | Venglustat | small molecule | DB14966 | Details | |||
D545 | Abrocitinib | small molecule | DB14973 | Details | |||
D546 | Ursolic acid | small molecule | DB15588 | Details |