Research Articles
Research articles concerning CKD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in CKDdb are presented with knowledge graphs.
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Insulin resistance55 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00002 | 10199785 | J Clin Endocrinol Metab | Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. | 1999 | Details |
| A00005 | 10480624 | Diabetes | A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. | 1999 | Details |
| A00012 | 10720087 | J Clin Endocrinol Metab | Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. | 2000 | Details |
| A00014 | 10852449 | J Clin Endocrinol Metab | The I27L amino acid polymorphism of hepatic nuclear factor-1alpha is associated with insulin resistance. | 2000 | Details |
| A00015 | 10902787 | J Clin Endocrinol Metab | Alterations in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes. | 2000 | Details |
| A00019 | 11030756 | Hum Mol Genet | Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. | 2000 | Details |
| A00026 | 11473060 | Diabetes | New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes. | 2001 | Details |
| A00027 | 11533494 | Science | Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. | 2001 | Details |
| A00028 | 11558907 | J Hum Genet | Single nucleotide polymorphisms of the resistin (RSTN) gene. | 2001 | Details |
| A00031 | 11739459 | J Clin Endocrinol Metab | The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. | 2001 | Details |
| A00034 | 11833006 | Am J Hum Genet | A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance. | 2002 | Details |
| A00039 | 12118251 | Nat Genet | Digenic inheritance of severe insulin resistance in a human pedigree. | 2002 | Details |
| A00042 | 12560873 | J Hum Genet | The interleukin 6-174G/C polymorphism is associated with indices of obesity in men. | 2003 | Details |
| A00043 | 12629116 | J Clin Endocrinol Metab | Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population. | 2003 | Details |
| A00044 | 12679424 | J Clin Endocrinol Metab | A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. | 2003 | Details |
| A00047 | 12750520 | Science | Mitochondrial dysfunction in the elderly: possible role in insulin resistance. | 2003 | Details |
| A00053 | 1314826 | J Biol Chem | Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action. | 1992 | Details |
| A00054 | 1357346 | Lancet | Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. | 1992 | Details |
| A00057 | 14671192 | J Clin Endocrinol Metab | Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance. | 2004 | Details |
| A00058 | 14960743 | N Engl J Med | Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. | 2004 | Details |
| A00060 | 15001634 | J Clin Endocrinol Metab | The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. | 2004 | Details |
| A00063 | 15126514 | J Clin Endocrinol Metab | The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. | 2004 | Details |
| A00064 | 15126519 | J Clin Endocrinol Metab | The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. | 2004 | Details |
| A00065 | 15166380 | Science | A family with severe insulin resistance and diabetes due to a mutation in AKT2. | 2004 | Details |
| A00070 | 15924147 | Nat Med | Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. | 2005 | Details |
| A00073 | 16025115 | Nat Genet | Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. | 2005 | Details |
| A00074 | 16034410 | Nature | Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. | 2005 | Details |
| A00075 | 1607076 | Diabetes | NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene. | 1992 | Details |
| A00080 | 16607460 | J Hum Genet | No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population. | 2006 | Details |
| A00082 | 16775236 | N Engl J Med | Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. | 2006 | Details |
| A00084 | 16968801 | J Clin Endocrinol Metab | ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children. | 2007 | Details |
| A00089 | 17273962 | Am J Hum Genet | Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. | 2007 | Details |
| A00092 | 17460697 | Nat Genet | A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. | 2007 | Details |
| A00093 | 17463246 | Science | Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. | 2007 | Details |
| A00102 | 17652184 | Mol Endocrinol | Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. | 2008 | Details |
| A00104 | 17726085 | J Clin Endocrinol Metab | Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. | 2008 | Details |
| A00105 | 17906635 | Nat Med | Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | 2007 | Details |
| A00106 | 18008060 | Diabetologia | The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. | 2008 | Details |
| A00111 | 18364377 | J Clin Endocrinol Metab | The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. | 2008 | Details |
| A00112 | 18477659 | J Clin Endocrinol Metab | Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. | 2008 | Details |
| A00117 | 1890161 | J Clin Endocrinol Metab | A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. | 1991 | Details |
| A00121 | 19164855 | J Clin Invest | Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. | 2009 | Details |
| A00123 | 1963473 | Mol Endocrinol | Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor. | 1991 | Details |
| A00125 | 19657112 | N Engl J Med | Sex hormone-binding globulin and risk of type 2 diabetes in women and men. | 2009 | Details |
| A00131 | 20353613 | Genome Med | Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. | 2011 | Details |
| A00134 | 20574426 | J Hum Genet | The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. | 2011 | Details |
| A00151 | 24994926 | J Am Soc Nephrol | Tolvaptan plus pasireotide shows enhanced efficacy in a PKD1 model. | 2015 | Details |
| A00154 | 25646624 | PLoS One | An efficient and comprehensive strategy for genetic diagnostics of polycystic kidney disease. | 2016 | Details |
| A00158 | 26150605 | J Am Soc Nephrol | The PROPKD Score: A New Algorithm to Predict Renal Survival in Autosomal Dominant Polycystic Kidney Disease. | 2016 | Details |
| A00185 | 32634120 | JCI Insight | The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD. | 2021 | Details |
| A00187 | 33097957 | Nephrol Dial Transplant | Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans. | 2021 | Details |
| A00195 | 39684653 | Int J Mol Sci | Pharmacological Nephroprotection in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus-Clinical Practice Position Statement of the Polish Society of Nephrology. | 2024 | Details |
| A00196 | 39704168 | JCI Insight | Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes. | 2024 | Details |
| A00200 | 39804512 | Langenbecks Arch Surg | A hypocaloric protein-rich diet before metabolic surgery improves liver function in patients with obesity and diabetes : A secondary analysis of a randomized clinical trial. | 2025 | Details |
| A00201 | 39806375 | Cardiovasc Diabetol | Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial. | 2025 | Details |