Research Article Details
Article ID: | A00154 |
PMID: | 25646624 |
Source: | PLoS One |
Title: | An efficient and comprehensive strategy for genetic diagnostics of polycystic kidney disease. |
Abstract: | Renal cysts are clinically and genetically heterogeneous conditions. Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent life-threatening genetic disease and mainly caused by mutations in PKD1. The presence of six PKD1 pseudogenes and tremendous allelic heterogeneity make molecular genetic testing challenging requiring laborious locus-specific amplification. Increasing evidence suggests a major role for PKD1 in early and severe cases of ADPKD and some patients with a recessive form. Furthermore it is becoming obvious that clinical manifestations can be mimicked by mutations in a number of other genes with the necessity for broader genetic testing. We established and validated a sequence capture based NGS testing approach for all genes known for cystic and polycystic kidney disease including PKD1. Thereby, we demonstrate that the applied standard mapping algorithm specifically aligns reads to the PKD1 locus and overcomes the complication of unspecific capture of pseudogenes. Employing careful and experienced assessment of NGS data, the method is shown to be very specific and equally sensitive as established methods. An additional advantage over conventional Sanger sequencing is the detection of copy number variations (CNVs). Sophisticated bioinformatic read simulation increased the high analytical depth of the validation study and further demonstrated the strength of the approach. We further raise some awareness of limitations and pitfalls of common NGS workflows when applied in complex regions like PKD1 demonstrating that quality of NGS needs more than high coverage of the target region. By this, we propose a time- and cost-efficient diagnostic strategy for comprehensive molecular genetic testing of polycystic kidney disease which is highly automatable and will be of particular value when therapeutic options for PKD emerge and genetic testing is needed for larger numbers of patients. |
DOI: | 10.1371/journal.pone.0116680 |

Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
---|
Diseases ID | DO ID | Disease Name | Definition | Class | |
---|---|---|---|---|---|
I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |
Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
---|---|---|---|---|---|---|---|
D001 | Leuprolide | small molecule | DB00007 | Details | |||
D002 | Goserelin | small molecule | DB00014 | Details | |||
D003 | Cetrorelix | small molecule | DB00050 | Details | |||
D004 | Pyridoxal phosphate | small molecule | DB00114 | Details | |||
D005 | Histidine | small molecule | DB00117 | Details | |||
D006 | Phenylalanine | small molecule | DB00120 | Details | |||
D007 | Biotin | small molecule | DB00121 | Details | |||
D008 | Choline | small molecule | DB00122 | Details | |||
D009 | L-Lysine | small molecule | DB00123 | Details | |||
D010 | Arginine | small molecule | DB00125 | Details | |||
D011 | Ascorbic acid | small molecule | DB00126 | Details | |||
D012 | Aspartic acid | small molecule | DB00128 | Details | |||
D013 | Ornithine | small molecule | DB00129 | Details | |||
D014 | L-Glutamine | small molecule | DB00130 | Details | |||
D015 | Serine | small molecule | DB00133 | Details | |||
D016 | Methionine | small molecule | DB00134 | Details | |||
D017 | Tyrosine | small molecule | DB00135 | Details | |||
D018 | Calcitriol | small molecule | DB00136 | Details | |||
D019 | Lutein | small molecule | DB00137 | Details | |||
D020 | Riboflavin | small molecule | DB00140 | Details | |||
D021 | Glutamic acid | small molecule | DB00142 | Details | |||
D022 | Phosphatidyl serine | small molecule | DB00144 | Details | |||
D023 | Glycine | small molecule | DB00145 | Details | |||
D024 | Calcifediol | small molecule | DB00146 | Details | |||
D025 | Pyridoxal | small molecule | DB00147 | Details | |||
D026 | Creatine | small molecule | DB00148 | Details | |||
D027 | Leucine | small molecule | DB00149 | Details | |||
D028 | Tryptophan | small molecule | DB00150 | Details | |||
D029 | Cysteine | small molecule | DB00151 | Details | |||
D030 | Thiamine | small molecule | DB00152 | Details | |||
D031 | Ergocalciferol | small molecule | DB00153 | Details | |||
D032 | Threonine | small molecule | DB00156 | Details | |||
D033 | Alanine | small molecule | DB00160 | Details | |||
D034 | Valine | small molecule | DB00161 | Details | |||
D035 | Vitamin A | small molecule | DB00162 | Details | |||
D036 | Vitamin E | small molecule | DB00163 | Details | |||
D037 | Pyridoxine | small molecule | DB00165 | Details | |||
D038 | Isoleucine | small molecule | DB00167 | Details | |||
D039 | Cholecalciferol | small molecule | DB00169 | Details | |||
D040 | Menadione | small molecule | DB00170 | Details | |||
D041 | Proline | small molecule | DB00172 | Details | |||
D042 | Pravastatin | small molecule | DB00175 | Details | |||
D043 | Valsartan | small molecule | DB00177 | Details | |||
D044 | Ramipril | small molecule | DB00178 | Details | |||
D045 | Esmolol | small molecule | DB00187 | Details | |||
D046 | Bortezomib | small molecule | DB00188 | Details | |||
D047 | Phentermine | small molecule | DB00191 | Details | |||
D048 | Tramadol | small molecule | DB00193 | Details | |||
D049 | Fluconazole | small molecule | DB00196 | Details | |||
D050 | Troglitazone | small molecule | DB00197 | Details | |||
D051 | Oseltamivir | small molecule | DB00198 | Details | |||
D052 | Erythromycin | small molecule | DB00199 | Details | |||
D053 | Caffeine | small molecule | DB00201 | Details | |||
D054 | Reserpine | small molecule | DB00206 | Details | |||
D055 | Azithromycin | small molecule | DB00207 | Details | |||
D056 | Pantoprazole | small molecule | DB00213 | Details | |||
D057 | Torasemide | small molecule | DB00214 | Details | |||
D058 | Citalopram | small molecule | DB00215 | Details | |||
D059 | Moxifloxacin | small molecule | DB00218 | Details | |||
D060 | Indinavir | small molecule | DB00224 | Details | |||
D061 | Lovastatin | small molecule | DB00227 | Details | |||
D062 | Pregabalin | small molecule | DB00230 | Details | |||
D063 | Nevirapine | small molecule | DB00238 | Details | |||
D064 | Ranolazine | small molecule | DB00243 | Details | |||
D065 | Ziprasidone | small molecule | DB00246 | Details | |||
D066 | Doxycycline | small molecule | DB00254 | Details | |||
D067 | Clotrimazole | small molecule | DB00257 | Details | |||
D068 | Metoprolol | small molecule | DB00264 | Details | |||
D069 | Ropinirole | small molecule | DB00268 | Details | |||
D070 | Chlorotrianisene | small molecule | DB00269 | Details | |||
D071 | Topiramate | small molecule | DB00273 | Details | |||
D072 | Olmesartan | small molecule | DB00275 | Details | |||
D073 | Theophylline | small molecule | DB00277 | Details | |||
D074 | Lidocaine | small molecule | DB00281 | Details | |||
D075 | Pamidronic acid | small molecule | DB00282 | Details | |||
D076 | Chlorambucil | small molecule | DB00291 | Details | |||
D077 | Morphine | small molecule | DB00295 | Details | |||
D078 | Bupivacaine | small molecule | DB00297 | Details | |||
D079 | Tranexamic acid | small molecule | DB00302 | Details | |||
D080 | Ertapenem | small molecule | DB00303 | Details | |||
D081 | Mitomycin | small molecule | DB00305 | Details | |||
D082 | Chlorthalidone | small molecule | DB00310 | Details | |||
D083 | Valproic acid | small molecule | DB00313 | Details | |||
D084 | Acetaminophen | small molecule | DB00316 | Details | |||
D085 | Piperacillin | small molecule | DB00319 | Details | |||
D086 | Amitriptyline | small molecule | DB00321 | Details | |||
D087 | Nitroprusside | small molecule | DB00325 | Details | |||
D088 | Indomethacin | small molecule | DB00328 | Details | |||
D089 | Metformin | small molecule | DB00331 | Details | |||
D090 | Methadone | small molecule | DB00333 | Details | |||
D091 | Olanzapine | small molecule | DB00334 | Details | |||
D092 | Atenolol | small molecule | DB00335 | Details | |||
D093 | Cetirizine | small molecule | DB00341 | Details | |||
D094 | Diltiazem | small molecule | DB00343 | Details | |||
D095 | Minoxidil | small molecule | DB00350 | Details | |||
D096 | Chlorzoxazone | small molecule | DB00356 | Details | |||
D097 | Clozapine | small molecule | DB00363 | Details | |||
D098 | Levonorgestrel | small molecule | DB00367 | Details | |||
D099 | Norepinephrine | small molecule | DB00368 | Details | |||
D100 | Cidofovir | small molecule | DB00369 | Details | |||
D101 | Mirtazapine | small molecule | DB00370 | Details | |||
D102 | Treprostinil | small molecule | DB00374 | Details | |||
D103 | Dydrogesterone | small molecule | DB00378 | Details | |||
D104 | Amlodipine | small molecule | DB00381 | Details | |||
D105 | Triamterene | small molecule | DB00384 | Details | |||
D106 | Phenylephrine | small molecule | DB00388 | Details | |||
D107 | Digoxin | small molecule | DB00390 | Details | |||
D108 | Nimodipine | small molecule | DB00393 | Details | |||
D109 | Progesterone | small molecule | DB00396 | Details | |||
D110 | Sorafenib | small molecule | DB00398 | Details | |||
D111 | Zoledronic acid | small molecule | DB00399 | Details | |||
D112 | Eszopiclone | small molecule | DB00402 | Details | |||
D113 | Alprazolam | small molecule | DB00404 | Details | |||
D114 | Loxapine | small molecule | DB00408 | Details | |||
D115 | Mupirocin | small molecule | DB00410 | Details | |||
D116 | Rosiglitazone | small molecule | DB00412 | Details | |||
D117 | Acetohexamide | small molecule | DB00414 | Details | |||
D118 | Ampicillin | small molecule | DB00415 | Details | |||
D119 | Spironolactone | small molecule | DB00421 | Details | |||
D120 | Methocarbamol | small molecule | DB00423 | Details | |||
D121 | Zolpidem | small molecule | DB00425 | Details | |||
D122 | Nitric Oxide | small molecule | DB00435 | Details | |||
D123 | Ceftazidime | small molecule | DB00438 | Details | |||
D124 | Trimethoprim | small molecule | DB00440 | Details | |||
D125 | Betamethasone | small molecule | DB00443 | Details | |||
D126 | Lansoprazole | small molecule | DB00448 | Details | |||
D127 | Loratadine | small molecule | DB00455 | Details | |||
D128 | Imipramine | small molecule | DB00458 | Details | |||
D129 | Dronabinol | small molecule | DB00470 | Details | |||
D130 | Montelukast | small molecule | DB00471 | Details | |||
D131 | Fluoxetine | small molecule | DB00472 | Details | |||
D132 | Duloxetine | small molecule | DB00476 | Details | |||
D133 | Chlorpromazine | small molecule | DB00477 | Details | |||
D134 | Amikacin | small molecule | DB00479 | Details | |||
D135 | Lenalidomide | small molecule | DB00480 | Details | |||
D136 | Celecoxib | small molecule | DB00482 | Details | |||
D137 | Altretamine | small molecule | DB00488 | Details | |||
D138 | Miglitol | small molecule | DB00491 | Details | |||
D139 | Cefotaxime | small molecule | DB00493 | Details | |||
D140 | Zidovudine | small molecule | DB00495 | Details | |||
D141 | Oxycodone | small molecule | DB00497 | Details | |||
D142 | Cimetidine | small molecule | DB00501 | Details | |||
D143 | Ritonavir | small molecule | DB00503 | Details | |||
D144 | Nitazoxanide | small molecule | DB00507 | Details | |||
D145 | Vancomycin | small molecule | DB00512 | Details | |||
D146 | Aminocaproic acid | small molecule | DB00513 | Details | |||
D147 | Trandolapril | small molecule | DB00519 | Details | |||
D148 | Metolazone | small molecule | DB00524 | Details | |||
D149 | Tolnaftate | small molecule | DB00525 | Details | |||
D150 | Lercanidipine | small molecule | DB00528 | Details | |||
D151 | Cyclophosphamide | small molecule | DB00531 | Details | |||
D152 | Ciprofloxacin | small molecule | DB00537 | Details | |||
D153 | Benazepril | small molecule | DB00542 | Details | |||
D154 | Propylthiouracil | small molecule | DB00550 | Details | |||
D155 | Zanamivir | small molecule | DB00558 | Details | |||
D156 | Bosentan | small molecule | DB00559 | Details | |||
D157 | Methotrexate | small molecule | DB00563 | Details | |||
D158 | Cisatracurium | small molecule | DB00565 | Details | |||
D159 | Cephalexin | small molecule | DB00567 | Details | |||
D160 | Propranolol | small molecule | DB00571 | Details | |||
D161 | Atropine | small molecule | DB00572 | Details | |||
D162 | Clonidine | small molecule | DB00575 | Details | |||
D163 | Lactulose | small molecule | DB00581 | Details | |||
D164 | Voriconazole | small molecule | DB00582 | Details | |||
D165 | Diclofenac | small molecule | DB00586 | Details | |||
D166 | Doxazosin | small molecule | DB00590 | Details | |||
D167 | Amiloride | small molecule | DB00594 | Details | |||
D168 | Labetalol | small molecule | DB00598 | Details | |||
D169 | Thiopental | small molecule | DB00599 | Details | |||
D170 | Linezolid | small molecule | DB00601 | Details | |||
D171 | Cisapride | small molecule | DB00604 | Details | |||
D172 | Nafcillin | small molecule | DB00607 | Details | |||
D173 | Chloroquine | small molecule | DB00608 | Details | |||
D174 | Bisoprolol | small molecule | DB00612 | Details | |||
D175 | Fluphenazine | small molecule | DB00623 | Details | |||
D176 | Testosterone | small molecule | DB00624 | Details | |||
D177 | Efavirenz | small molecule | DB00625 | Details | |||
D178 | Bacitracin | small molecule | DB00626 | Details | |||
D179 | Niacin | small molecule | DB00627 | Details | |||
D180 | Alendronic acid | small molecule | DB00630 | Details | |||
D181 | Prednisone | small molecule | DB00635 | Details | |||
D182 | Inulin | small molecule | DB00638 | Details | |||
D183 | Adenosine | small molecule | DB00640 | Details | |||
D184 | Simvastatin | small molecule | DB00641 | Details | |||
D185 | Stavudine | small molecule | DB00649 | Details | |||
D186 | Trazodone | small molecule | DB00656 | Details | |||
D187 | Verapamil | small molecule | DB00661 | Details | |||
D188 | Epinephrine | small molecule | DB00668 | Details | |||
D189 | Pirenzepine | small molecule | DB00670 | Details | |||
D190 | Cefixime | small molecule | DB00671 | Details | |||
D191 | Chlorpropamide | small molecule | DB00672 | Details | |||
D192 | Losartan | small molecule | DB00678 | Details | |||
D193 | Thioridazine | small molecule | DB00679 | Details | |||
D194 | Warfarin | small molecule | DB00682 | Details | |||
D195 | Midazolam | small molecule | DB00683 | Details | |||
D196 | Tobramycin | small molecule | DB00684 | Details | |||
D197 | Fludrocortisone | small molecule | DB00687 | Details | |||
D198 | Phentolamine | small molecule | DB00692 | Details | |||
D199 | Furosemide | small molecule | DB00695 | Details | |||
D200 | Eplerenone | small molecule | DB00700 | Details | |||
D201 | Amprenavir | small molecule | DB00701 | Details | |||
D202 | Naltrexone | small molecule | DB00704 | Details | |||
D203 | Tamsulosin | small molecule | DB00706 | Details | |||
D204 | Lamivudine | small molecule | DB00709 | Details | |||
D205 | Ibandronate | small molecule | DB00710 | Details | |||
D206 | Flurbiprofen | small molecule | DB00712 | Details | |||
D207 | Oxacillin | small molecule | DB00713 | Details | |||
D208 | Paroxetine | small molecule | DB00715 | Details | |||
D209 | Lisinopril | small molecule | DB00722 | Details | |||
D210 | Nitroglycerin | small molecule | DB00727 | Details | |||
D211 | Rocuronium | small molecule | DB00728 | Details | |||
D212 | Risperidone | small molecule | DB00734 | Details | |||
D213 | Esomeprazole | small molecule | DB00736 | Details | |||
D214 | Pentamidine | small molecule | DB00738 | Details | |||
D215 | Hydrocortisone | small molecule | DB00741 | Details | |||
D216 | Mannitol | small molecule | DB00742 | Details | |||
D217 | Deferoxamine | small molecule | DB00746 | Details | |||
D218 | Prilocaine | small molecule | DB00750 | Details | |||
D219 | Isoflurane | small molecule | DB00753 | Details | |||
D220 | Clopidogrel | small molecule | DB00758 | Details | |||
D221 | Methimazole | small molecule | DB00763 | Details | |||
D222 | Clavulanic acid | small molecule | DB00766 | Details | |||
D223 | Alprostadil | small molecule | DB00770 | Details | |||
D224 | Mefenamic acid | small molecule | DB00784 | Details | |||
D225 | Perindopril | small molecule | DB00790 | Details | |||
D226 | Alfentanil | small molecule | DB00802 | Details | |||
D227 | Pentoxifylline | small molecule | DB00806 | Details | |||
D228 | Indapamide | small molecule | DB00808 | Details | |||
D229 | Tropicamide | small molecule | DB00809 | Details | |||
D230 | Ribavirin | small molecule | DB00811 | Details | |||
D231 | Fentanyl | small molecule | DB00813 | Details | |||
D232 | Propofol | small molecule | DB00818 | Details | |||
D233 | Acetazolamide | small molecule | DB00819 | Details | |||
D234 | Tadalafil | small molecule | DB00820 | Details | |||
D235 | Fosfomycin | small molecule | DB00828 | Details | |||
D236 | Diazepam | small molecule | DB00829 | Details | |||
D237 | Trifluoperazine | small molecule | DB00831 | Details | |||
D238 | Mifepristone | small molecule | DB00834 | Details | |||
D239 | Tolazamide | small molecule | DB00839 | Details | |||
D240 | Dobutamine | small molecule | DB00841 | Details | |||
D241 | Donepezil | small molecule | DB00843 | Details | |||
D242 | Nalbuphine | small molecule | DB00844 | Details | |||
D243 | Levamisole | small molecule | DB00848 | Details | |||
D244 | Perphenazine | small molecule | DB00850 | Details | |||
D245 | Pseudoephedrine | small molecule | DB00852 | Details | |||
D246 | Aminolevulinic acid | small molecule | DB00855 | Details | |||
D247 | Terbinafine | small molecule | DB00857 | Details | |||
D248 | Prednisolone | small molecule | DB00860 | Details | |||
D249 | Diflunisal | small molecule | DB00861 | Details | |||
D250 | Terbutaline | small molecule | DB00871 | Details | |||
D251 | Guaifenesin | small molecule | DB00874 | Details | |||
D252 | Eprosartan | small molecule | DB00876 | Details | |||
D253 | Sirolimus | small molecule | DB00877 | Details | |||
D254 | Emtricitabine | small molecule | DB00879 | Details | |||
D255 | Quinapril | small molecule | DB00881 | Details | |||
D256 | Isosorbide dinitrate | small molecule | DB00883 | Details | |||
D257 | Mechlorethamine | small molecule | DB00888 | Details | |||
D258 | Ethanol | small molecule | DB00898 | Details | |||
D259 | Remifentanil | small molecule | DB00899 | Details | |||
D260 | Ondansetron | small molecule | DB00904 | Details | |||
D261 | Cocaine | small molecule | DB00907 | Details | |||
D262 | Repaglinide | small molecule | DB00912 | Details | |||
D263 | Phenformin | small molecule | DB00914 | Details | |||
D264 | Amantadine | small molecule | DB00915 | Details | |||
D265 | Metronidazole | small molecule | DB00916 | Details | |||
D266 | Dinoprostone | small molecule | DB00917 | Details | |||
D267 | Buprenorphine | small molecule | DB00921 | Details | |||
D268 | Azacitidine | small molecule | DB00928 | Details | |||
D269 | Misoprostol | small molecule | DB00929 | Details | |||
D270 | Mesoridazine | small molecule | DB00933 | Details | |||
D271 | Oxymetazoline | small molecule | DB00935 | Details | |||
D272 | Salicylic acid | small molecule | DB00936 | Details | |||
D273 | Acetylsalicylic acid | small molecule | DB00945 | Details | |||
D274 | Phenprocoumon | small molecule | DB00946 | Details | |||
D275 | Fexofenadine | small molecule | DB00950 | Details | |||
D276 | Isoniazid | small molecule | DB00951 | Details | |||
D277 | Norgestimate | small molecule | DB00957 | Details | |||
D278 | Methylprednisolone | small molecule | DB00959 | Details | |||
D279 | Mepivacaine | small molecule | DB00961 | Details | |||
D280 | Zaleplon | small molecule | DB00962 | Details | |||
D281 | Bromfenac | small molecule | DB00963 | Details | |||
D282 | Telmisartan | small molecule | DB00966 | Details | |||
D283 | Methyldopa | small molecule | DB00968 | Details | |||
D284 | Ezetimibe | small molecule | DB00973 | Details | |||
D285 | Edetic acid | small molecule | DB00974 | Details | |||
D286 | Dipyridamole | small molecule | DB00975 | Details | |||
D287 | Ethinylestradiol | small molecule | DB00977 | Details | |||
D288 | Physostigmine | small molecule | DB00981 | Details | |||
D289 | Isotretinoin | small molecule | DB00982 | Details | |||
D290 | Nandrolone phenpropionate | small molecule | DB00984 | Details | |||
D291 | Glycopyrronium | small molecule | DB00986 | Details | |||
D292 | Dopamine | small molecule | DB00988 | Details | |||
D293 | Azathioprine | small molecule | DB00993 | Details | |||
D294 | Gabapentin | small molecule | DB00996 | Details | |||
D295 | Frovatriptan | small molecule | DB00998 | Details | |||
D296 | Hydrochlorothiazide | small molecule | DB00999 | Details | |||
D297 | Salbutamol | small molecule | DB01001 | Details | |||
D298 | Levobupivacaine | small molecule | DB01002 | Details | |||
D299 | Hydroxyurea | small molecule | DB01005 | Details | |||
D300 | Letrozole | small molecule | DB01006 | Details | |||
D301 | Metyrapone | small molecule | DB01011 | Details | |||
D302 | Cinacalcet | small molecule | DB01012 | Details | |||
D303 | Sulfamethoxazole | small molecule | DB01015 | Details | |||
D304 | Bethanechol | small molecule | DB01019 | Details | |||
D305 | Phylloquinone | small molecule | DB01022 | Details | |||
D306 | Felodipine | small molecule | DB01023 | Details | |||
D307 | Mycophenolic acid | small molecule | DB01024 | Details | |||
D308 | Amlexanox | small molecule | DB01025 | Details | |||
D309 | Irbesartan | small molecule | DB01029 | Details | |||
D310 | Probenecid | small molecule | DB01032 | Details | |||
D311 | Fenofibrate | small molecule | DB01039 | Details | |||
D312 | Thalidomide | small molecule | DB01041 | Details | |||
D313 | Ibuprofen | small molecule | DB01050 | Details | |||
D314 | Benzylpenicillin | small molecule | DB01053 | Details | |||
D315 | Amoxicillin | small molecule | DB01060 | Details | |||
D316 | Melatonin | small molecule | DB01065 | Details | |||
D317 | Glipizide | small molecule | DB01067 | Details | |||
D318 | Promethazine | small molecule | DB01069 | Details | |||
D319 | Diphenhydramine | small molecule | DB01075 | Details | |||
D320 | Atorvastatin | small molecule | DB01076 | Details | |||
D321 | Vigabatrin | small molecule | DB01080 | Details | |||
D322 | Streptomycin | small molecule | DB01082 | Details | |||
D323 | Orlistat | small molecule | DB01083 | Details | |||
D324 | Pilocarpine | small molecule | DB01085 | Details | |||
D325 | Benzocaine | small molecule | DB01086 | Details | |||
D326 | Dimethyl sulfoxide | small molecule | DB01093 | Details | |||
D327 | Pimozide | small molecule | DB01100 | Details | |||
D328 | Sertraline | small molecule | DB01104 | Details | |||
D329 | Miconazole | small molecule | DB01110 | Details | |||
D330 | Nifedipine | small molecule | DB01115 | Details | |||
D331 | Amiodarone | small molecule | DB01118 | Details | |||
D332 | Diazoxide | small molecule | DB01119 | Details | |||
D333 | Gliclazide | small molecule | DB01120 | Details | |||
D334 | Tolbutamide | small molecule | DB01124 | Details | |||
D335 | Dutasteride | small molecule | DB01126 | Details | |||
D336 | Pioglitazone | small molecule | DB01132 | Details | |||
D337 | Carvedilol | small molecule | DB01136 | Details | |||
D338 | Levofloxacin | small molecule | DB01137 | Details | |||
D339 | Cefadroxil | small molecule | DB01140 | Details | |||
D340 | Bupropion | small molecule | DB01156 | Details | |||
D341 | Terazosin | small molecule | DB01162 | Details | |||
D342 | Ofloxacin | small molecule | DB01165 | Details | |||
D343 | Cilostazol | small molecule | DB01166 | Details | |||
D344 | Itraconazole | small molecule | DB01167 | Details | |||
D345 | Chlormezanone | small molecule | DB01178 | Details | |||
D346 | Naloxone | small molecule | DB01183 | Details | |||
D347 | Domperidone | small molecule | DB01184 | Details | |||
D348 | Ciclopirox | small molecule | DB01188 | Details | |||
D349 | Desflurane | small molecule | DB01189 | Details | |||
D350 | Clindamycin | small molecule | DB01190 | Details | |||
D351 | Dexfenfluramine | small molecule | DB01191 | Details | |||
D352 | Captopril | small molecule | DB01197 | Details | |||
D353 | Zopiclone | small molecule | DB01198 | Details | |||
D354 | Bromocriptine | small molecule | DB01200 | Details | |||
D355 | Clarithromycin | small molecule | DB01211 | Details | |||
D356 | Ceftriaxone | small molecule | DB01212 | Details | |||
D357 | Anastrozole | small molecule | DB01217 | Details | |||
D358 | Dantrolene | small molecule | DB01219 | Details | |||
D359 | Budesonide | small molecule | DB01222 | Details | |||
D360 | Quetiapine | small molecule | DB01224 | Details | |||
D361 | Paclitaxel | small molecule | DB01229 | Details | |||
D362 | Metoclopramide | small molecule | DB01233 | Details | |||
D363 | Dexamethasone | small molecule | DB01234 | Details | |||
D364 | Sevoflurane | small molecule | DB01236 | Details | |||
D365 | Aripiprazole | small molecule | DB01238 | Details | |||
D366 | Epoprostenol | small molecule | DB01240 | Details | |||
D367 | Gliquidone | small molecule | DB01251 | Details | |||
D368 | Dasatinib | small molecule | DB01254 | Details | |||
D369 | Lapatinib | small molecule | DB01259 | Details | |||
D370 | Darunavir | small molecule | DB01264 | Details | |||
D371 | Sunitinib | small molecule | DB01268 | Details | |||
D372 | Hydralazine | small molecule | DB01275 | Details | |||
D373 | Lumiracoxib | small molecule | DB01283 | Details | |||
D374 | Glucosamine | small molecule | DB01296 | Details | |||
D375 | Cefazolin | small molecule | DB01327 | Details | |||
D376 | Vecuronium | small molecule | DB01339 | Details | |||
D377 | Cilazapril | small molecule | DB01340 | Details | |||
D378 | Spirapril | small molecule | DB01348 | Details | |||
D379 | Ephedrine | small molecule | DB01364 | Details | |||
D380 | Yohimbine | small molecule | DB01392 | Details | |||
D381 | Bezafibrate | small molecule | DB01393 | Details | |||
D382 | Colchicine | small molecule | DB01394 | Details | |||
D383 | Drospirenone | small molecule | DB01395 | Details | |||
D384 | Methotrimeprazine | small molecule | DB01403 | Details | |||
D385 | Clenbuterol | small molecule | DB01407 | Details | |||
D386 | Theobromine | small molecule | DB01412 | Details | |||
D387 | Cefepime | small molecule | DB01413 | Details | |||
D388 | Alfacalcidol | small molecule | DB01436 | Details | |||
D389 | Diamorphine | small molecule | DB01452 | Details | |||
D390 | Metamfetamine | small molecule | DB01577 | Details | |||
D391 | Sulfamethazine | small molecule | DB01582 | Details | |||
D392 | Ursodeoxycholic acid | small molecule | DB01586 | Details | |||
D393 | Probucol | small molecule | DB01599 | Details | |||
D394 | Lopinavir | small molecule | DB01601 | Details | |||
D395 | Tazobactam | small molecule | DB01606 | Details | |||
D396 | Hydroxychloroquine | small molecule | DB01611 | Details | |||
D397 | Molindone | small molecule | DB01618 | Details | |||
D398 | Thiothixene | small molecule | DB01623 | Details | |||
D399 | Sorbitol | small molecule | DB01638 | Details | |||
D400 | Genistein | small molecule | DB01645 | Details | |||
D401 | N,N-dimethylarginine | small molecule | DB01686 | Details | |||
D402 | Prasterone | small molecule | DB01708 | Details | |||
D403 | Pantothenic acid | small molecule | DB01783 | Details | |||
D404 | Taurine | small molecule | DB01956 | Details | |||
D405 | Calcipotriol | small molecule | DB02300 | Details | |||
D406 | Thymol | small molecule | DB02513 | Details | |||
D407 | gamma-Aminobutyric acid | small molecule | DB02530 | Details | |||
D408 | Terlipressin | small molecule | DB02638 | Details | |||
D409 | Nicotinamide | small molecule | DB02701 | Details | |||
D410 | Fusidic acid | small molecule | DB02703 | Details | |||
D411 | Resveratrol | small molecule | DB02709 | Details | |||
D412 | Oxitriptan | small molecule | DB02959 | Details | |||
D413 | Glycolic acid | small molecule | DB03085 | Details | |||
D414 | Acetylcholine | small molecule | DB03128 | Details | |||
D415 | Acetic acid | small molecule | DB03166 | Details | |||
D416 | Phenol | small molecule | DB03255 | Details | |||
D417 | Palmitic Acid | small molecule | DB03796 | Details | |||
D418 | Eucalyptol | small molecule | DB03852 | Details | |||
D419 | Citric acid | small molecule | DB04272 | Details | |||
D420 | Maleic Acid | small molecule | DB04299 | Details | |||
D421 | N,N,N-trimethylglycinium | small molecule | DB04455 | Details | |||
D422 | Meso-Erythritol | small molecule | DB04481 | Details | |||
D423 | Indole | small molecule | DB04532 | Details | |||
D424 | Arachidonic Acid | small molecule | DB04557 | Details | |||
D425 | Buformin | small molecule | DB04830 | Details | |||
D426 | Methaqualone | small molecule | DB04833 | Details | |||
D427 | Cyproterone acetate | small molecule | DB04839 | Details | |||
D428 | Fluspirilene | small molecule | DB04842 | Details | |||
D429 | Tetrabenazine | small molecule | DB04844 | Details | |||
D430 | Febuxostat | small molecule | DB04854 | Details | |||
D431 | Nebivolol | small molecule | DB04861 | Details | |||
D432 | Vildagliptin | small molecule | DB04876 | Details | |||
D433 | Voglibose | small molecule | DB04878 | Details | |||
D434 | Iloperidone | small molecule | DB04946 | Details | |||
D435 | Lobeline | small molecule | DB05137 | Details | |||
D436 | Histamine | small molecule | DB05381 | Details | |||
D437 | Iodine | small molecule | DB05382 | Details | |||
D438 | Levoketoconazole | small molecule | DB05667 | Details | |||
D439 | Acetylcysteine | small molecule | DB06151 | Details | |||
D440 | Atrasentan | small molecule | DB06199 | Details | |||
D441 | Rivaroxaban | small molecule | DB06228 | Details | |||
D442 | Eflornithine | small molecule | DB06243 | Details | |||
D443 | Sitaxentan | small molecule | DB06268 | Details | |||
D444 | Amisulpride | small molecule | DB06288 | Details | |||
D445 | Dapagliflozin | small molecule | DB06292 | Details | |||
D446 | Darapladib | small molecule | DB06311 | Details | |||
D447 | Saxagliptin | small molecule | DB06335 | Details | |||
D448 | Ambrisentan | small molecule | DB06403 | Details | |||
D449 | Etravirine | small molecule | DB06414 | Details | |||
D450 | Prucalopride | small molecule | DB06480 | Details | |||
D451 | Cetilistat | small molecule | DB06586 | Details | |||
D452 | Agomelatine | small molecule | DB06594 | Details | |||
D453 | Apixaban | small molecule | DB06605 | Details | |||
D454 | Bosutinib | small molecule | DB06616 | Details | |||
D455 | Desvenlafaxine | small molecule | DB06700 | Details | |||
D456 | Methyltestosterone | small molecule | DB06710 | Details | |||
D457 | Beta carotene | small molecule | DB06755 | Details | |||
D458 | Manganese | small molecule | DB06757 | Details | |||
D459 | Capsaicin | small molecule | DB06774 | Details | |||
D460 | Chenodeoxycholic acid | small molecule | DB06777 | Details | |||
D461 | Cupric sulfate | small molecule | DB06778 | Details | |||
D462 | Lanreotide | small molecule | DB06791 | Details | |||
D463 | Plerixafor | small molecule | DB06809 | Details | |||
D464 | Phenylbutyric acid | small molecule | DB06819 | Details | |||
D465 | 4,4'-PROPANE-2,2-DIYLDIPHENOL | small molecule | DB06973 | Details | |||
D466 | Emodin | small molecule | DB07715 | Details | |||
D467 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | small molecule | DB07919 | Details | |||
D468 | Parecoxib | small molecule | DB08439 | Details | |||
D469 | Triclosan | small molecule | DB08604 | Details | |||
D470 | Nandrolone decanoate | small molecule | DB08804 | Details | |||
D471 | Ticagrelor | small molecule | DB08816 | Details | |||
D472 | Deferiprone | small molecule | DB08826 | Details | |||
D473 | Uric acid | small molecule | DB08844 | Details | |||
D474 | Pitavastatin | small molecule | DB08860 | Details | |||
D475 | Rilpivirine | small molecule | DB08864 | Details | |||
D476 | Linaclotide | small molecule | DB08890 | Details | |||
D477 | Tofacitinib | small molecule | DB08895 | Details | |||
D478 | Dimethyl fumarate | small molecule | DB08908 | Details | |||
D479 | Sofosbuvir | small molecule | DB08934 | Details | |||
D480 | Dexetimide | small molecule | DB08997 | Details | |||
D481 | Bisacodyl | small molecule | DB09020 | Details | |||
D482 | Aliskiren | small molecule | DB09026 | Details | |||
D483 | Ledipasvir | small molecule | DB09027 | Details | |||
D484 | Acipimox | small molecule | DB09055 | Details | |||
D485 | Ciprofibrate | small molecule | DB09064 | Details | |||
D486 | Olaparib | small molecule | DB09074 | Details | |||
D487 | Benzoyl peroxide | small molecule | DB09096 | Details | |||
D488 | Coenzyme M | small molecule | DB09110 | Details | |||
D489 | Nicorandil | small molecule | DB09220 | Details | |||
D490 | Manidipine | small molecule | DB09238 | Details | |||
D491 | Methylene blue | small molecule | DB09241 | Details | |||
D492 | Moxonidine | small molecule | DB09242 | Details | |||
D493 | Ubidecarenone | small molecule | DB09270 | Details | |||
D494 | Silibinin | small molecule | DB09298 | Details | |||
D495 | Glycerin | small molecule | DB09462 | Details | |||
D496 | Methyl salicylate | small molecule | DB09543 | Details | |||
D497 | Ixazomib | small molecule | DB09570 | Details | |||
D498 | Hydrogen peroxide | small molecule | DB11091 | Details | |||
D499 | Lycopene | small molecule | DB11231 | Details | |||
D500 | Medetomidine | small molecule | DB11428 | Details | |||
D501 | Lesinurad | small molecule | DB11560 | Details | |||
D502 | Carbon monoxide | small molecule | DB11588 | Details | |||
D503 | Curcumin | small molecule | DB11672 | Details | |||
D504 | Pyridoxamine | small molecule | DB11673 | Details | |||
D505 | Equol | small molecule | DB11674 | Details | |||
D506 | Mosapride | small molecule | DB11675 | Details | |||
D507 | Ebastine | small molecule | DB11742 | Details | |||
D508 | Rifamycin | small molecule | DB11753 | Details | |||
D509 | Imidapril | small molecule | DB11783 | Details | |||
D510 | Angiotensin II | small molecule | DB11842 | Details | |||
D511 | Verinurad | small molecule | DB11873 | Details | |||
D512 | 2,4-thiazolidinedione | small molecule | DB11898 | Details | |||
D513 | Zuretinol acetate | small molecule | DB12112 | Details | |||
D514 | Bradykinin | small molecule | DB12126 | Details | |||
D515 | Sarpogrelate | small molecule | DB12163 | Details | |||
D516 | Secoisolariciresinol | small molecule | DB12179 | Details | |||
D517 | Bexagliflozin | small molecule | DB12236 | Details | |||
D518 | Benzbromarone | small molecule | DB12319 | Details | |||
D519 | Nitroaspirin | small molecule | DB12445 | Details | |||
D520 | Piperine | small molecule | DB12582 | Details | |||
D521 | Isoquercetin | small molecule | DB12665 | Details | |||
D522 | Cicletanine | small molecule | DB12766 | Details | |||
D523 | Gallopamil | small molecule | DB12923 | Details | |||
D524 | Lactitol | small molecule | DB12942 | Details | |||
D525 | Daidzein | small molecule | DB13182 | Details | |||
D526 | Camostat | small molecule | DB13729 | Details | |||
D527 | Fenofibric acid | small molecule | DB13873 | Details | |||
D528 | Candesartan | small molecule | DB13919 | Details | |||
D529 | Testosterone enanthate | small molecule | DB13944 | Details | |||
D530 | Ferric cation | small molecule | DB13949 | Details | |||
D531 | Palmidrol | small molecule | DB14043 | Details | |||
D532 | Cianidanol | small molecule | DB14086 | Details | |||
D533 | Tenofovir | small molecule | DB14126 | Details | |||
D534 | Cinnamaldehyde | small molecule | DB14184 | Details | |||
D535 | Cobaltous cation | small molecule | DB14205 | Details | |||
D536 | Chromic cation | small molecule | DB14525 | Details | |||
D537 | Zinc cation | small molecule | DB14532 | Details | |||
D538 | Cupric cation | small molecule | DB14552 | Details | |||
D539 | Bismuth cation | small molecule | DB14572 | Details | |||
D540 | Calcium cation | small molecule | DB14577 | Details | |||
D541 | Cortisone | small molecule | DB14681 | Details | |||
D542 | Dabigatran | small molecule | DB14726 | Details | |||
D543 | Remdesivir | small molecule | DB14761 | Details | |||
D544 | Venglustat | small molecule | DB14966 | Details | |||
D545 | Abrocitinib | small molecule | DB14973 | Details | |||
D546 | Ursolic acid | small molecule | DB15588 | Details |