Repositioning Candidate Details
| Candidate ID: | R0032 |
| Source ID: | DB00156 |
| Source Type: | approved; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Threonine |
| Synonyms: | |
| Molecular Formula: | C4H9NO3 |
| SMILES: | C[C@@H](O)[C@H](N)C(O)=O |
| Structure: |
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| DrugBank Description: | An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins. |
| CAS Number: | 72-19-5 |
| Molecular Weight: | 119.1192 |
| DrugBank Indication: | L-Threonine makes up collagen, elastin, and enamel protein. It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation. |
| DrugBank Pharmacology: | L-Threonine is an essential amino acid that helps to maintain the proper protein balance in the body. It is important for the formation of collagen, elastin, and tooth enamel, and aids liver and lipotropic function when combined with aspartic acid and methionine. |
| DrugBank MoA: | L-Threonine is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver. May help combat mental illness and may be very useful in indigestion and intestinal malfunctions. Also, threonine prevents excessive liver fat. Nutrients are more readily absorbed when threonine is present. |
| Targets: | Threonine--tRNA ligase, cytoplasmic; Threonine--tRNA ligase, mitochondrial; Beta-lactamase Toho-1 |
| Inclusion Criteria: |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |