Investigational Drug Details
Drug ID: | D155 |
Drug Name: | Zanamivir |
Synonyms: | |
Type: | small molecule |
DrugBank ID: | DB00558 |
DrugBank Description: | A guanido-neuraminic acid that is used to inhibit neuraminidase. |
PubChem ID: | 60855 |
CasNo: | 139110-80-8 |
Repositioning for NAFLD: | Yes |
SMILES: | [H][C@]1(OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO |
Structure: |
|
InChiKey: | ARAIBEBZBOPLMB-UFGQHTETSA-N |
Molecular Weight: | 332.3098 |
DrugBank Targets: | Neuraminidase; Neuraminidase; Sialidase-2 |
DrugBank MoA: | The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release. By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others. |
DrugBank Pharmacology: | Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days. Zanamivir has also been shown to significantly inhibit the human sialidases NEU3 and NEU2 in the micromolar range (Ki 3.7 +/-0.48 and 12.9+/-0.07 microM, respectively), which could account for some of the rare side effects of zanamivir. |
DrugBank Indication: | For the prevention and treatment of influenza A and B. |
Targets: | |
Therapeutic Category: | |
Clinical Trial Progress: | |
Latest Progress: |

Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
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Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
---|---|---|---|---|---|---|---|
T03 | Angiotensin-converting enzyme | ACE | INHIBITOR | Target is a single protein chain | P12821 | ACE_HUMAN | Details |
T47 | Sialin | SLC17A5 | Target is a single protein chain | Q9NRA2 | SLC17A5_HUMAN | Details | |
T06 | Sulfonylurea receptor 1 | ABCC8 | Target is a single protein chain | Q09428 | ABCC8_HUMAN | Details | |
T15 | Steryl-sulfatase | STS | INHIBITOR | Hydrolase | P08842 | STS_HUMAN | Details |
Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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Article ID | PMID | Source | Title |
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