Investigational Drug Details
| Drug ID: | D032 |
| Drug Name: | Threonine |
| Synonyms: | |
| Type: | small molecule |
| DrugBank ID: | DB00156 |
| DrugBank Description: | An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins. |
| PubChem ID: | 6288 |
| CasNo: | 72-19-5 |
| Repositioning for NAFLD: | Yes |
| SMILES: | C[C@@H](O)[C@H](N)C(O)=O |
| Structure: |
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| InChiKey: | AYFVYJQAPQTCCC-GBXIJSLDSA-N |
| Molecular Weight: | 119.1192 |
| DrugBank Targets: | Threonine--tRNA ligase, cytoplasmic; Threonine--tRNA ligase, mitochondrial; Beta-lactamase Toho-1 |
| DrugBank MoA: | L-Threonine is a precursor to the amino acids glycine and serine. It acts as a lipotropic in controlling fat build-up in the liver. May help combat mental illness and may be very useful in indigestion and intestinal malfunctions. Also, threonine prevents excessive liver fat. Nutrients are more readily absorbed when threonine is present. |
| DrugBank Pharmacology: | L-Threonine is an essential amino acid that helps to maintain the proper protein balance in the body. It is important for the formation of collagen, elastin, and tooth enamel, and aids liver and lipotropic function when combined with aspartic acid and methionine. |
| DrugBank Indication: | L-Threonine makes up collagen, elastin, and enamel protein. It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation. |
| Targets: | |
| Therapeutic Category: | |
| Clinical Trial Progress: | |
| Latest Progress: |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
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| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00027 | 11533494 | Science | Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. | Details |
| A00065 | 15166380 | Science | A family with severe insulin resistance and diabetes due to a mutation in AKT2. | Details |
| A00134 | 20574426 | J Hum Genet | The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. | Details |
| A00136 | 21118154 | Biochem J | LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. | Details |
| A00137 | 21186350 | Nat Genet | Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. | Details |
| A00143 | 23275527 | J Clin Endocrinol Metab | Genotype and phenotype correlations in 417 children with congenital hyperinsulinism. | Details |
| A00155 | 25741167 | World J Gastroenterol | Hepatic phenotypes of HNF1B gene mutations: a case of neonatal cholestasis requiring portoenterostomy and literature review. | Details |
| A00188 | 33141305 | Clin Exp Nephrol | Effect of tolvaptan on renal involvement in patients with autosomal dominant polycystic kidney disease according to different gene mutations. | Details |