Therapeutic Target Details
| Target ID: | T03 |
| Target Name: | Angiotensin-converting enzyme |
| Synonyms: | DCP; DCP1; Synonyms=DCP; Angiotensin-converting enzyme; Angiotensin-converting enzyme, soluble form; Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen=CD143; ACE; 3.4.15.1 |
| GENE: | ACE |
| Action: | INHIBITOR |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P12821 |
| Entry Name: | ACE_HUMAN |
| Related Drugs: | Quinapril Hydrochloride; Trandolapril; Moexipril Hydrochloride; Enalaprilat; Ramipril; Fosinopril Sodium; Benazepril Hydrochloride; Captopril; Perindopril Erbumine; Lisinopril; Enalapril Maleate; Spirapril Hydrochloride; Perindopril Arginine; Cilazapril; Imidapril; Delapril; Ilepatril |
| Mechanism: | Angiotensin-converting enzyme inhibitor |
| Reference (PMIDs): | 16126915; 1712267; 1712710; 18311667; 20849865; 2209711; 24383331; 24754013; 25272892; 25845252; 33731923 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D023 | Glycine | small molecule | DB00145 | Details | |||
| D024 | Calcifediol | small molecule | DB00146 | Details | |||
| D037 | Pyridoxine | small molecule | DB00165 | Details | |||
| D055 | Azithromycin | small molecule | DB00207 | Details | |||
| D067 | Clotrimazole | small molecule | DB00257 | Details | |||
| D076 | Chlorambucil | small molecule | DB00291 | Details | |||
| D088 | Indomethacin | small molecule | DB00328 | Details | |||
| D098 | Levonorgestrel | small molecule | DB00367 | Details | |||
| D104 | Amlodipine | small molecule | DB00381 | Details | |||
| D111 | Zoledronic acid | small molecule | DB00399 | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0023 | DB00145 | approved; nutraceutical; vet_approved | small molecule | Glycine | Details | |
| R0024 | DB00146 | approved; nutraceutical | small molecule | Calcifediol | Details | |
| R0037 | DB00165 | approved; investigational; nutraceutical; vet_approved | small molecule | Pyridoxine | Details | |
| R0055 | DB00207 | approved | small molecule | Azithromycin | Details | |
| R0067 | DB00257 | approved; vet_approved | small molecule | Clotrimazole | Details | |
| R0076 | DB00291 | approved | small molecule | Chlorambucil | Details | |
| R0088 | DB00328 | approved; investigational | small molecule | Indomethacin | Details | |
| R0098 | DB00367 | approved; investigational | small molecule | Levonorgestrel | Details | |
| R0104 | DB00381 | approved | small molecule | Amlodipine | Details | |
| R0111 | DB00399 | approved | small molecule | Zoledronic acid | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000148 | CHEMBL6246 | Small molecule | ELLAGIC ACID | 302.19 | C14H6O8 | ACID | Details |
| B001248 | CHEMBL6915 | Small molecule | 295.4 | C15H21NO3S | ACID | Details | |
| B001564 | CHEMBL28 | Small molecule | APIGENIN | 270.24 | C15H10O5 | NEUTRAL | Details |
| B001967 | CHEMBL431 | Small molecule | SPIRAPRIL | 466.63 | C22H30N2O5S2 | ACID | Details |
| B003891 | CHEMBL8486 | Small molecule | MDL-28170 | 264.32 | C14H20N2O3 | ZWITTERION | Details |
| B006104 | CHEMBL9941 | Small molecule | 344.36 | C19H20O6 | NEUTRAL | Details | |
| B006579 | CHEMBL76 | Small molecule | CHLOROQUINE | 319.88 | C18H26ClN3 | BASE | Details |
| B006816 | CHEMBL10247 | Small molecule | THIORPHAN | 253.32 | C12H15NO3S | ACID | Details |
| B006946 | CHEMBL10465 | Small molecule | 422.48 | C24H26N2O5 | ACID | Details | |
| B007000 | CHEMBL10521 | Small molecule | 542.68 | C31H43F3N4O8 | ZWITTERION | Details |