Therapeutic Target Details
| Target ID: | T13 |
| Target Name: | Renin |
| Synonyms: | Renin; Angiotensinogenase; 3.4.23.15 |
| GENE: | REN |
| Action: | INHIBITOR |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P00797 |
| Entry Name: | REN_HUMAN |
| Related Drugs: | Aliskiren Fumarate; Imarikiren Hydrochloride; Sph-3127 |
| Mechanism: | Renin inhibitor |
| Reference (PMIDs): | 30092100; 31494843 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D014 | L-Glutamine | small molecule | DB00130 | Details | |||
| D018 | Calcitriol | small molecule | DB00136 | Details | |||
| D023 | Glycine | small molecule | DB00145 | Details | |||
| D024 | Calcifediol | small molecule | DB00146 | Details | |||
| D037 | Pyridoxine | small molecule | DB00165 | Details | |||
| D049 | Fluconazole | small molecule | DB00196 | Details | |||
| D067 | Clotrimazole | small molecule | DB00257 | Details | |||
| D081 | Mitomycin | small molecule | DB00305 | Details | |||
| D089 | Metformin | small molecule | DB00331 | Details | |||
| D104 | Amlodipine | small molecule | DB00381 | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0014 | DB00130 | approved; investigational; nutraceutical | small molecule | L-Glutamine | Details | |
| R0018 | DB00136 | approved; nutraceutical | small molecule | Calcitriol | Details | |
| R0023 | DB00145 | approved; nutraceutical; vet_approved | small molecule | Glycine | Details | |
| R0024 | DB00146 | approved; nutraceutical | small molecule | Calcifediol | Details | |
| R0037 | DB00165 | approved; investigational; nutraceutical; vet_approved | small molecule | Pyridoxine | Details | |
| R0049 | DB00196 | approved; investigational | small molecule | Fluconazole | Details | |
| R0067 | DB00257 | approved; vet_approved | small molecule | Clotrimazole | Details | |
| R0081 | DB00305 | approved | small molecule | Mitomycin | Details | |
| R0089 | DB00331 | approved | small molecule | Metformin | Details | |
| R0104 | DB00381 | approved | small molecule | Amlodipine | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B001994 | CHEMBL434 | Small molecule | ISOPROTERENOL | 211.26 | C11H17NO3 | BASE | Details |
| B004475 | CHEMBL8665 | Small molecule | 654.87 | C32H54N4O8S | NEUTRAL | Details | |
| B004476 | CHEMBL406692 | Small molecule | 710.98 | C33H50N4O7S3 | NEUTRAL | Details | |
| B004478 | CHEMBL276372 | Small molecule | 760.96 | C36H56N8O8S | NEUTRAL | Details | |
| B004605 | CHEMBL267955 | Small molecule | 772.91 | C35H54F2N6O9S | NEUTRAL | Details | |
| B004659 | CHEMBL441325 | Small molecule | 694.81 | C31H49F3N4O8S | NEUTRAL | Details | |
| B004660 | CHEMBL8896 | Small molecule | 753.0 | C35H56N6O8S2 | NEUTRAL | Details | |
| B004661 | CHEMBL276553 | Small molecule | 774.93 | C35H56F2N6O9S | NEUTRAL | Details | |
| B004697 | CHEMBL267277 | Small molecule | 676.88 | C33H52N6O7S | NEUTRAL | Details | |
| B004718 | CHEMBL8477 | Small molecule | 668.92 | C32H52N4O7S2 | NEUTRAL | Details |