Therapeutic Target Details
| Target ID: | T19 |
| Target Name: | Hexokinase type IV |
| Synonyms: | Hexokinase-4; Glucokinase; Hexokinase type IV; Hexokinase-D; HK4; HK IV; 2.7.1.1 |
| GENE: | GCK |
| Action: | ACTIVATOR |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P35557 |
| Entry Name: | GCK_HUMAN |
| Related Drugs: | Azd-1656; Dorzagliatin; Nerigliatin; Pf-04991532; Mk-0941; Ly-2608204 |
| Mechanism: | Hexokinase type IV activator |
| Reference (PMIDs): | 21994424; 22943931; 24858947; 27870481; 29626326; 29707866; 35067153 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B301508 | CHEMBL181375 | Small molecule | 472.41 | C16H14BrN3O3S3 | NEUTRAL | Details | |
| B301509 | CHEMBL180600 | Small molecule | 473.4 | C15H13BrN4O3S3 | NEUTRAL | Details | |
| B301518 | CHEMBL181943 | Small molecule | 384.33 | C17H19Cl2N3OS | NEUTRAL | Details | |
| B301520 | CHEMBL359665 | Small molecule | 507.66 | C22H25N3O5S3 | NEUTRAL | Details | |
| B301521 | CHEMBL182246 | Small molecule | 411.89 | C16H14ClN3O4S2 | NEUTRAL | Details | |
| B301528 | CHEMBL180858 | Small molecule | 415.92 | C16H18ClN3O4S2 | NEUTRAL | Details | |
| B301531 | CHEMBL181713 | Small molecule | 348.43 | C16H20N4O3S | ACID | Details | |
| B301533 | CHEMBL541979 | Small molecule | 432.75 | C16H16BrClFN3OS | NEUTRAL | Details | |
| B301535 | CHEMBL181635 | Small molecule | 337.4 | C16H17F2N3OS | NEUTRAL | Details | |
| B301539 | CHEMBL360582 | Small molecule | 365.89 | C17H20ClN3O2S | NEUTRAL | Details |
| Article ID | PMID | Source | Title |
|---|