Therapeutic Target Details
| Target ID: | T02 |
| Target Name: | Alpha-2a adrenergic receptor |
| Synonyms: | ADRA2R; ADRAR; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR |
| GENE: | ADRA2A |
| Action: | |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P08913 |
| Entry Name: | ADRA2A_HUMAN |
| Related Drugs: | |
| Mechanism: | |
| Reference (PMIDs): |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D033 | Alanine | small molecule | DB00160 | Details | |||
| D050 | Troglitazone | small molecule | DB00197 | Details | |||
| D051 | Oseltamivir | small molecule | DB00198 | Details | |||
| D095 | Minoxidil | small molecule | DB00350 | Details | |||
| D120 | Methocarbamol | small molecule | DB00423 | Details | |||
| D136 | Celecoxib | small molecule | DB00482 | Details | |||
| D173 | Chloroquine | small molecule | DB00608 | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0033 | DB00160 | nutraceutical | small molecule | Alanine | Details | |
| R0050 | DB00197 | approved; investigational; withdrawn | small molecule | Troglitazone | Details | |
| R0051 | DB00198 | approved | small molecule | Oseltamivir | Details | |
| R0095 | DB00350 | approved; investigational | small molecule | Minoxidil | Details | |
| R0120 | DB00423 | approved; vet_approved | small molecule | Methocarbamol | Details | |
| R0136 | DB00482 | approved; investigational | small molecule | Celecoxib | Details | |
| R0173 | DB00608 | approved; investigational; vet_approved | small molecule | Chloroquine | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000097 | CHEMBL2 | Small molecule | PRAZOSIN | 383.41 | C19H21N5O4 | NEUTRAL | Details |
| B000322 | CHEMBL269538 | Small molecule | HARMINE | 212.25 | C13H12N2O | NEUTRAL | Details |
| B000323 | CHEMBL6857 | Small molecule | 251.13 | C11H11BrN2 | BASE | Details | |
| B000351 | CHEMBL6310 | Small molecule | 202.26 | C12H14N2O | BASE | Details | |
| B000573 | CHEMBL6437 | Small molecule | MIANSERIN | 264.37 | C18H20N2 | NEUTRAL | Details |
| B000711 | CHEMBL404505 | Small molecule | 186.21 | C11H10N2O | NEUTRAL | Details | |
| B000860 | CHEMBL411 | Small molecule | DIETHYLSTILBESTROL | 268.36 | C18H20O2 | NEUTRAL | Details |
| B000996 | CHEMBL415 | Small molecule | CLOMIPRAMINE | 314.86 | C19H23ClN2 | BASE | Details |
| B001202 | CHEMBL420 | Small molecule | GUANABENZ | 231.09 | C8H8Cl2N4 | NEUTRAL | Details |
| B001219 | CHEMBL6966 | Small molecule | VERAPAMIL | 454.61 | C27H38N2O4 | BASE | Details |
| Article ID | PMID | Source | Title |
|---|