Therapeutic Target Details
| Target ID: | T28 |
| Target Name: | Interleukin-6 |
| Synonyms: | IFNB2; Interleukin-6; B-cell stimulatory factor 2; CTL differentiation factor; Hybridoma growth factor; Interferon beta-2; IL-6; BSF-2; CDF; IFN-beta-2 |
| GENE: | IL6 |
| Action: | ANTAGONIST; INHIBITOR; BINDING AGENT |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P05231 |
| Entry Name: | IL6_HUMAN |
| Related Drugs: | |
| Mechanism: | Interleukin-6 inhibitor; Interleukin-6 binding agent |
| Reference (PMIDs): | 1715218; 21392075; 24670876; 26138593; 26744529; 27672124 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress |
|---|
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria |
|---|
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B003183 | CHEMBL46 | Small molecule | ONDANSETRON | 293.37 | C18H19N3O | NEUTRAL | Details |
| B027370 | CHEMBL131 | Small molecule | PREDNISOLONE | 360.45 | C21H28O5 | NEUTRAL | Details |
| B145082 | CHEMBL91194 | Small molecule | MADINDOLINE A | 369.46 | C22H27NO4 | NEUTRAL | Details |
| B347112 | CHEMBL382330 | Small molecule | 369.46 | C22H27NO4 | NEUTRAL | Details | |
| B439312 | CHEMBL273019 | Small molecule | BERGENIN | 328.27 | C14H16O9 | NEUTRAL | Details |
| B1376048 | CHEMBL2103778 | Small molecule | CILANSETRON | 319.41 | C20H21N3O | NEUTRAL | Details |
| B1626747 | CHEMBL3137316 | Small molecule | FOSDAGROCORAT | 574.54 | C29H30F3N2O5P | ACID | Details |
| B1980208 | CHEMBL3647439 | Small molecule | 536.64 | C32H35F3N2O2 | NEUTRAL | Details | |
| B1980209 | CHEMBL3647440 | Small molecule | 509.57 | C29H30F3N3O2 | NEUTRAL | Details | |
| B1980210 | CHEMBL3647441 | Small molecule | 522.61 | C31H33F3N2O2 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00012 | 10720087 | J Clin Endocrinol Metab | Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. | Details |
| A00018 | 11001912 | Blood | An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. | Details |
| A00035 | 11889177 | J Clin Endocrinol Metab | The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism. | Details |
| A00041 | 12519862 | J Clin Endocrinol Metab | Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. | Details |
| A00042 | 12560873 | J Hum Genet | The interleukin 6-174G/C polymorphism is associated with indices of obesity in men. | Details |
| A00045 | 12719374 | Hum Mol Genet | Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. | Details |
| A00058 | 14960743 | N Engl J Med | Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. | Details |
| A00062 | 15070960 | J Clin Endocrinol Metab | Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. | Details |
| A00066 | 15331795 | Stroke | Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. | Details |
| A00067 | 15472205 | J Clin Endocrinol Metab | Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes. | Details |
| A00077 | 16150725 | Proc Natl Acad Sci U S A | Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children. | Details |
| A00078 | 16278864 | Ann Neurol | Interleukin-6 involvement in brain arteriovenous malformations. | Details |
| A00101 | 17623760 | J Clin Endocrinol Metab | Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. | Details |
| A00206 | 39910843 | Ren Fail | Artificial intelligence in kidney transplantation: a 30-year bibliometric analysis of research trends, innovations, and future directions. | Details |