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Research Article Details

Article ID: A00035
PMID: 11889177
Source: J Clin Endocrinol Metab
Title: The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism.
Abstract: To evaluate whether genetic variability at the IL-6 gene (IL-6) is associated with hyperandrogenism, we studied four common polymorphisms in the IL-6 promoter (-597G-->A, -572G--> C, -373A(n)T(n), -174G-->C) in 85 hyperandrogenic patients and 25 healthy women. We found 5 different haplotypes when considering the 3 biallelic polymorphisms at positions -597, -572, and -174 of IL-6 (relative frequencies in parentheses): GGG (0.505), AGC (0.377), GGC (0.059), GCG (0.055), and GCC (0.005). The frequencies of the GGG haplotype were 0.559 in patients and 0.320 in controls, whereas those of the AGC haplotype were 0.318 in patients and 0.580 in controls (chi(2) = 12.145; P < 0.02). The -597G-->A and -174G-->C polymorphisms were in linkage disequilibrium (chi(2) = 152.220; P < 0.00001), and were associated with patient or control status. -597G and -174G alleles were more frequent in patients in homozygosity or considering subjects homozygous and heterozygous for G alleles as a whole (P < 0.05 for all analyses). In healthy women G alleles at -597 and -174 were associated with statistically significant higher circulating levels of IL-6 and basal cortisol, 11-deoxycortisol, and 17-hydroxyprogesterone and a tendency (P < 0.10) for higher total T concentrations compared with -597A and -174C alleles. On the contrary, neither the -572G-->C nor the -373A(n)T(n) polymorphism was related to hyperandrogenism or influenced any clinical or biochemical variable. In conclusion, our present results suggest that the -597G-->A and -174G-->C polymorphisms in IL-6 are involved in the pathogenesis of hyperandrogenic disorders.
DOI: 10.1210/jcem.87.3.8309

Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs

Target ID Target Name GENE Action Class UniProtKB ID Entry Name
T28 Interleukin-6 IL6 ANTAGONIST; INHIBITOR; BINDING AGENT Target is a single protein chain P05231 IL6_HUMAN Details

Diseases ID DO ID Disease Name Definition Class
I02 1184 nephrotic syndrome "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] Details

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
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D004 Pyridoxal phosphate small molecule DB00114 Details
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D006 Phenylalanine small molecule DB00120 Details
D007 Biotin small molecule DB00121 Details
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D009 L-Lysine small molecule DB00123 Details
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D011 Ascorbic acid small molecule DB00126 Details
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D013 Ornithine small molecule DB00129 Details
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D015 Serine small molecule DB00133 Details
D016 Methionine small molecule DB00134 Details
D017 Tyrosine small molecule DB00135 Details
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D019 Lutein small molecule DB00137 Details
D020 Riboflavin small molecule DB00140 Details
D021 Glutamic acid small molecule DB00142 Details
D022 Phosphatidyl serine small molecule DB00144 Details
D023 Glycine small molecule DB00145 Details
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D025 Pyridoxal small molecule DB00147 Details
D026 Creatine small molecule DB00148 Details
D027 Leucine small molecule DB00149 Details
D028 Tryptophan small molecule DB00150 Details
D029 Cysteine small molecule DB00151 Details
D030 Thiamine small molecule DB00152 Details
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D034 Valine small molecule DB00161 Details
D035 Vitamin A small molecule DB00162 Details
D036 Vitamin E small molecule DB00163 Details
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D038 Isoleucine small molecule DB00167 Details
D039 Cholecalciferol small molecule DB00169 Details
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D046 Bortezomib small molecule DB00188 Details
D047 Phentermine small molecule DB00191 Details
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D073 Theophylline small molecule DB00277 Details
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D075 Pamidronic acid small molecule DB00282 Details
D076 Chlorambucil small molecule DB00291 Details
D077 Morphine small molecule DB00295 Details
D078 Bupivacaine small molecule DB00297 Details
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D096 Chlorzoxazone small molecule DB00356 Details
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D105 Triamterene small molecule DB00384 Details
D106 Phenylephrine small molecule DB00388 Details
D107 Digoxin small molecule DB00390 Details
D108 Nimodipine small molecule DB00393 Details
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D110 Sorafenib small molecule DB00398 Details
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D113 Alprazolam small molecule DB00404 Details
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D117 Acetohexamide small molecule DB00414 Details
D118 Ampicillin small molecule DB00415 Details
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D126 Lansoprazole small molecule DB00448 Details
D127 Loratadine small molecule DB00455 Details
D128 Imipramine small molecule DB00458 Details
D129 Dronabinol small molecule DB00470 Details
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D131 Fluoxetine small molecule DB00472 Details
D132 Duloxetine small molecule DB00476 Details
D133 Chlorpromazine small molecule DB00477 Details
D134 Amikacin small molecule DB00479 Details
D135 Lenalidomide small molecule DB00480 Details
D136 Celecoxib small molecule DB00482 Details
D137 Altretamine small molecule DB00488 Details
D138 Miglitol small molecule DB00491 Details
D139 Cefotaxime small molecule DB00493 Details
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D150 Lercanidipine small molecule DB00528 Details
D151 Cyclophosphamide small molecule DB00531 Details
D152 Ciprofloxacin small molecule DB00537 Details
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D161 Atropine small molecule DB00572 Details
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D167 Amiloride small molecule DB00594 Details
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D182 Inulin small molecule DB00638 Details
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D186 Trazodone small molecule DB00656 Details
D187 Verapamil small molecule DB00661 Details
D188 Epinephrine small molecule DB00668 Details
D189 Pirenzepine small molecule DB00670 Details
D190 Cefixime small molecule DB00671 Details
D191 Chlorpropamide small molecule DB00672 Details
D192 Losartan small molecule DB00678 Details
D193 Thioridazine small molecule DB00679 Details
D194 Warfarin small molecule DB00682 Details
D195 Midazolam small molecule DB00683 Details
D196 Tobramycin small molecule DB00684 Details
D197 Fludrocortisone small molecule DB00687 Details
D198 Phentolamine small molecule DB00692 Details
D199 Furosemide small molecule DB00695 Details
D200 Eplerenone small molecule DB00700 Details
D201 Amprenavir small molecule DB00701 Details
D202 Naltrexone small molecule DB00704 Details
D203 Tamsulosin small molecule DB00706 Details
D204 Lamivudine small molecule DB00709 Details
D205 Ibandronate small molecule DB00710 Details
D206 Flurbiprofen small molecule DB00712 Details
D207 Oxacillin small molecule DB00713 Details
D208 Paroxetine small molecule DB00715 Details
D209 Lisinopril small molecule DB00722 Details
D210 Nitroglycerin small molecule DB00727 Details
D211 Rocuronium small molecule DB00728 Details
D212 Risperidone small molecule DB00734 Details
D213 Esomeprazole small molecule DB00736 Details
D214 Pentamidine small molecule DB00738 Details
D215 Hydrocortisone small molecule DB00741 Details
D216 Mannitol small molecule DB00742 Details
D217 Deferoxamine small molecule DB00746 Details
D218 Prilocaine small molecule DB00750 Details
D219 Isoflurane small molecule DB00753 Details
D220 Clopidogrel small molecule DB00758 Details
D221 Methimazole small molecule DB00763 Details
D222 Clavulanic acid small molecule DB00766 Details
D223 Alprostadil small molecule DB00770 Details
D224 Mefenamic acid small molecule DB00784 Details
D225 Perindopril small molecule DB00790 Details
D226 Alfentanil small molecule DB00802 Details
D227 Pentoxifylline small molecule DB00806 Details
D228 Indapamide small molecule DB00808 Details
D229 Tropicamide small molecule DB00809 Details
D230 Ribavirin small molecule DB00811 Details
D231 Fentanyl small molecule DB00813 Details
D232 Propofol small molecule DB00818 Details
D233 Acetazolamide small molecule DB00819 Details
D234 Tadalafil small molecule DB00820 Details
D235 Fosfomycin small molecule DB00828 Details
D236 Diazepam small molecule DB00829 Details
D237 Trifluoperazine small molecule DB00831 Details
D238 Mifepristone small molecule DB00834 Details
D239 Tolazamide small molecule DB00839 Details
D240 Dobutamine small molecule DB00841 Details
D241 Donepezil small molecule DB00843 Details
D242 Nalbuphine small molecule DB00844 Details
D243 Levamisole small molecule DB00848 Details
D244 Perphenazine small molecule DB00850 Details
D245 Pseudoephedrine small molecule DB00852 Details
D246 Aminolevulinic acid small molecule DB00855 Details
D247 Terbinafine small molecule DB00857 Details
D248 Prednisolone small molecule DB00860 Details
D249 Diflunisal small molecule DB00861 Details
D250 Terbutaline small molecule DB00871 Details
D251 Guaifenesin small molecule DB00874 Details
D252 Eprosartan small molecule DB00876 Details
D253 Sirolimus small molecule DB00877 Details
D254 Emtricitabine small molecule DB00879 Details
D255 Quinapril small molecule DB00881 Details
D256 Isosorbide dinitrate small molecule DB00883 Details
D257 Mechlorethamine small molecule DB00888 Details
D258 Ethanol small molecule DB00898 Details
D259 Remifentanil small molecule DB00899 Details
D260 Ondansetron small molecule DB00904 Details
D261 Cocaine small molecule DB00907 Details
D262 Repaglinide small molecule DB00912 Details
D263 Phenformin small molecule DB00914 Details
D264 Amantadine small molecule DB00915 Details
D265 Metronidazole small molecule DB00916 Details
D266 Dinoprostone small molecule DB00917 Details
D267 Buprenorphine small molecule DB00921 Details
D268 Azacitidine small molecule DB00928 Details
D269 Misoprostol small molecule DB00929 Details
D270 Mesoridazine small molecule DB00933 Details
D271 Oxymetazoline small molecule DB00935 Details
D272 Salicylic acid small molecule DB00936 Details
D273 Acetylsalicylic acid small molecule DB00945 Details
D274 Phenprocoumon small molecule DB00946 Details
D275 Fexofenadine small molecule DB00950 Details
D276 Isoniazid small molecule DB00951 Details
D277 Norgestimate small molecule DB00957 Details
D278 Methylprednisolone small molecule DB00959 Details
D279 Mepivacaine small molecule DB00961 Details
D280 Zaleplon small molecule DB00962 Details
D281 Bromfenac small molecule DB00963 Details
D282 Telmisartan small molecule DB00966 Details
D283 Methyldopa small molecule DB00968 Details
D284 Ezetimibe small molecule DB00973 Details
D285 Edetic acid small molecule DB00974 Details
D286 Dipyridamole small molecule DB00975 Details
D287 Ethinylestradiol small molecule DB00977 Details
D288 Physostigmine small molecule DB00981 Details
D289 Isotretinoin small molecule DB00982 Details
D290 Nandrolone phenpropionate small molecule DB00984 Details
D291 Glycopyrronium small molecule DB00986 Details
D292 Dopamine small molecule DB00988 Details
D293 Azathioprine small molecule DB00993 Details
D294 Gabapentin small molecule DB00996 Details
D295 Frovatriptan small molecule DB00998 Details
D296 Hydrochlorothiazide small molecule DB00999 Details
D297 Salbutamol small molecule DB01001 Details
D298 Levobupivacaine small molecule DB01002 Details
D299 Hydroxyurea small molecule DB01005 Details
D300 Letrozole small molecule DB01006 Details
D301 Metyrapone small molecule DB01011 Details
D302 Cinacalcet small molecule DB01012 Details
D303 Sulfamethoxazole small molecule DB01015 Details
D304 Bethanechol small molecule DB01019 Details
D305 Phylloquinone small molecule DB01022 Details
D306 Felodipine small molecule DB01023 Details
D307 Mycophenolic acid small molecule DB01024 Details
D308 Amlexanox small molecule DB01025 Details
D309 Irbesartan small molecule DB01029 Details
D310 Probenecid small molecule DB01032 Details
D311 Fenofibrate small molecule DB01039 Details
D312 Thalidomide small molecule DB01041 Details
D313 Ibuprofen small molecule DB01050 Details
D314 Benzylpenicillin small molecule DB01053 Details
D315 Amoxicillin small molecule DB01060 Details
D316 Melatonin small molecule DB01065 Details
D317 Glipizide small molecule DB01067 Details
D318 Promethazine small molecule DB01069 Details
D319 Diphenhydramine small molecule DB01075 Details
D320 Atorvastatin small molecule DB01076 Details
D321 Vigabatrin small molecule DB01080 Details
D322 Streptomycin small molecule DB01082 Details
D323 Orlistat small molecule DB01083 Details
D324 Pilocarpine small molecule DB01085 Details
D325 Benzocaine small molecule DB01086 Details
D326 Dimethyl sulfoxide small molecule DB01093 Details
D327 Pimozide small molecule DB01100 Details
D328 Sertraline small molecule DB01104 Details
D329 Miconazole small molecule DB01110 Details
D330 Nifedipine small molecule DB01115 Details
D331 Amiodarone small molecule DB01118 Details
D332 Diazoxide small molecule DB01119 Details
D333 Gliclazide small molecule DB01120 Details
D334 Tolbutamide small molecule DB01124 Details
D335 Dutasteride small molecule DB01126 Details
D336 Pioglitazone small molecule DB01132 Details
D337 Carvedilol small molecule DB01136 Details
D338 Levofloxacin small molecule DB01137 Details
D339 Cefadroxil small molecule DB01140 Details
D340 Bupropion small molecule DB01156 Details
D341 Terazosin small molecule DB01162 Details
D342 Ofloxacin small molecule DB01165 Details
D343 Cilostazol small molecule DB01166 Details
D344 Itraconazole small molecule DB01167 Details
D345 Chlormezanone small molecule DB01178 Details
D346 Naloxone small molecule DB01183 Details
D347 Domperidone small molecule DB01184 Details
D348 Ciclopirox small molecule DB01188 Details
D349 Desflurane small molecule DB01189 Details
D350 Clindamycin small molecule DB01190 Details
D351 Dexfenfluramine small molecule DB01191 Details
D352 Captopril small molecule DB01197 Details
D353 Zopiclone small molecule DB01198 Details
D354 Bromocriptine small molecule DB01200 Details
D355 Clarithromycin small molecule DB01211 Details
D356 Ceftriaxone small molecule DB01212 Details
D357 Anastrozole small molecule DB01217 Details
D358 Dantrolene small molecule DB01219 Details
D359 Budesonide small molecule DB01222 Details
D360 Quetiapine small molecule DB01224 Details
D361 Paclitaxel small molecule DB01229 Details
D362 Metoclopramide small molecule DB01233 Details
D363 Dexamethasone small molecule DB01234 Details
D364 Sevoflurane small molecule DB01236 Details
D365 Aripiprazole small molecule DB01238 Details
D366 Epoprostenol small molecule DB01240 Details
D367 Gliquidone small molecule DB01251 Details
D368 Dasatinib small molecule DB01254 Details
D369 Lapatinib small molecule DB01259 Details
D370 Darunavir small molecule DB01264 Details
D371 Sunitinib small molecule DB01268 Details
D372 Hydralazine small molecule DB01275 Details
D373 Lumiracoxib small molecule DB01283 Details
D374 Glucosamine small molecule DB01296 Details
D375 Cefazolin small molecule DB01327 Details
D376 Vecuronium small molecule DB01339 Details
D377 Cilazapril small molecule DB01340 Details
D378 Spirapril small molecule DB01348 Details
D379 Ephedrine small molecule DB01364 Details
D380 Yohimbine small molecule DB01392 Details
D381 Bezafibrate small molecule DB01393 Details
D382 Colchicine small molecule DB01394 Details
D383 Drospirenone small molecule DB01395 Details
D384 Methotrimeprazine small molecule DB01403 Details
D385 Clenbuterol small molecule DB01407 Details
D386 Theobromine small molecule DB01412 Details
D387 Cefepime small molecule DB01413 Details
D388 Alfacalcidol small molecule DB01436 Details
D389 Diamorphine small molecule DB01452 Details
D390 Metamfetamine small molecule DB01577 Details
D391 Sulfamethazine small molecule DB01582 Details
D392 Ursodeoxycholic acid small molecule DB01586 Details
D393 Probucol small molecule DB01599 Details
D394 Lopinavir small molecule DB01601 Details
D395 Tazobactam small molecule DB01606 Details
D396 Hydroxychloroquine small molecule DB01611 Details
D397 Molindone small molecule DB01618 Details
D398 Thiothixene small molecule DB01623 Details
D399 Sorbitol small molecule DB01638 Details
D400 Genistein small molecule DB01645 Details
D401 N,N-dimethylarginine small molecule DB01686 Details
D402 Prasterone small molecule DB01708 Details
D403 Pantothenic acid small molecule DB01783 Details
D404 Taurine small molecule DB01956 Details
D405 Calcipotriol small molecule DB02300 Details
D406 Thymol small molecule DB02513 Details
D407 gamma-Aminobutyric acid small molecule DB02530 Details
D408 Terlipressin small molecule DB02638 Details
D409 Nicotinamide small molecule DB02701 Details
D410 Fusidic acid small molecule DB02703 Details
D411 Resveratrol small molecule DB02709 Details
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D415 Acetic acid small molecule DB03166 Details
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D418 Eucalyptol small molecule DB03852 Details
D419 Citric acid small molecule DB04272 Details
D420 Maleic Acid small molecule DB04299 Details
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D422 Meso-Erythritol small molecule DB04481 Details
D423 Indole small molecule DB04532 Details
D424 Arachidonic Acid small molecule DB04557 Details
D425 Buformin small molecule DB04830 Details
D426 Methaqualone small molecule DB04833 Details
D427 Cyproterone acetate small molecule DB04839 Details
D428 Fluspirilene small molecule DB04842 Details
D429 Tetrabenazine small molecule DB04844 Details
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D433 Voglibose small molecule DB04878 Details
D434 Iloperidone small molecule DB04946 Details
D435 Lobeline small molecule DB05137 Details
D436 Histamine small molecule DB05381 Details
D437 Iodine small molecule DB05382 Details
D438 Levoketoconazole small molecule DB05667 Details
D439 Acetylcysteine small molecule DB06151 Details
D440 Atrasentan small molecule DB06199 Details
D441 Rivaroxaban small molecule DB06228 Details
D442 Eflornithine small molecule DB06243 Details
D443 Sitaxentan small molecule DB06268 Details
D444 Amisulpride small molecule DB06288 Details
D445 Dapagliflozin small molecule DB06292 Details
D446 Darapladib small molecule DB06311 Details
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D448 Ambrisentan small molecule DB06403 Details
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D451 Cetilistat small molecule DB06586 Details
D452 Agomelatine small molecule DB06594 Details
D453 Apixaban small molecule DB06605 Details
D454 Bosutinib small molecule DB06616 Details
D455 Desvenlafaxine small molecule DB06700 Details
D456 Methyltestosterone small molecule DB06710 Details
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D458 Manganese small molecule DB06757 Details
D459 Capsaicin small molecule DB06774 Details
D460 Chenodeoxycholic acid small molecule DB06777 Details
D461 Cupric sulfate small molecule DB06778 Details
D462 Lanreotide small molecule DB06791 Details
D463 Plerixafor small molecule DB06809 Details
D464 Phenylbutyric acid small molecule DB06819 Details
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D466 Emodin small molecule DB07715 Details
D467 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE small molecule DB07919 Details
D468 Parecoxib small molecule DB08439 Details
D469 Triclosan small molecule DB08604 Details
D470 Nandrolone decanoate small molecule DB08804 Details
D471 Ticagrelor small molecule DB08816 Details
D472 Deferiprone small molecule DB08826 Details
D473 Uric acid small molecule DB08844 Details
D474 Pitavastatin small molecule DB08860 Details
D475 Rilpivirine small molecule DB08864 Details
D476 Linaclotide small molecule DB08890 Details
D477 Tofacitinib small molecule DB08895 Details
D478 Dimethyl fumarate small molecule DB08908 Details
D479 Sofosbuvir small molecule DB08934 Details
D480 Dexetimide small molecule DB08997 Details
D481 Bisacodyl small molecule DB09020 Details
D482 Aliskiren small molecule DB09026 Details
D483 Ledipasvir small molecule DB09027 Details
D484 Acipimox small molecule DB09055 Details
D485 Ciprofibrate small molecule DB09064 Details
D486 Olaparib small molecule DB09074 Details
D487 Benzoyl peroxide small molecule DB09096 Details
D488 Coenzyme M small molecule DB09110 Details
D489 Nicorandil small molecule DB09220 Details
D490 Manidipine small molecule DB09238 Details
D491 Methylene blue small molecule DB09241 Details
D492 Moxonidine small molecule DB09242 Details
D493 Ubidecarenone small molecule DB09270 Details
D494 Silibinin small molecule DB09298 Details
D495 Glycerin small molecule DB09462 Details
D496 Methyl salicylate small molecule DB09543 Details
D497 Ixazomib small molecule DB09570 Details
D498 Hydrogen peroxide small molecule DB11091 Details
D499 Lycopene small molecule DB11231 Details
D500 Medetomidine small molecule DB11428 Details
D501 Lesinurad small molecule DB11560 Details
D502 Carbon monoxide small molecule DB11588 Details
D503 Curcumin small molecule DB11672 Details
D504 Pyridoxamine small molecule DB11673 Details
D505 Equol small molecule DB11674 Details
D506 Mosapride small molecule DB11675 Details
D507 Ebastine small molecule DB11742 Details
D508 Rifamycin small molecule DB11753 Details
D509 Imidapril small molecule DB11783 Details
D510 Angiotensin II small molecule DB11842 Details
D511 Verinurad small molecule DB11873 Details
D512 2,4-thiazolidinedione small molecule DB11898 Details
D513 Zuretinol acetate small molecule DB12112 Details
D514 Bradykinin small molecule DB12126 Details
D515 Sarpogrelate small molecule DB12163 Details
D516 Secoisolariciresinol small molecule DB12179 Details
D517 Bexagliflozin small molecule DB12236 Details
D518 Benzbromarone small molecule DB12319 Details
D519 Nitroaspirin small molecule DB12445 Details
D520 Piperine small molecule DB12582 Details
D521 Isoquercetin small molecule DB12665 Details
D522 Cicletanine small molecule DB12766 Details
D523 Gallopamil small molecule DB12923 Details
D524 Lactitol small molecule DB12942 Details
D525 Daidzein small molecule DB13182 Details
D526 Camostat small molecule DB13729 Details
D527 Fenofibric acid small molecule DB13873 Details
D528 Candesartan small molecule DB13919 Details
D529 Testosterone enanthate small molecule DB13944 Details
D530 Ferric cation small molecule DB13949 Details
D531 Palmidrol small molecule DB14043 Details
D532 Cianidanol small molecule DB14086 Details
D533 Tenofovir small molecule DB14126 Details
D534 Cinnamaldehyde small molecule DB14184 Details
D535 Cobaltous cation small molecule DB14205 Details
D536 Chromic cation small molecule DB14525 Details
D537 Zinc cation small molecule DB14532 Details
D538 Cupric cation small molecule DB14552 Details
D539 Bismuth cation small molecule DB14572 Details
D540 Calcium cation small molecule DB14577 Details
D541 Cortisone small molecule DB14681 Details
D542 Dabigatran small molecule DB14726 Details
D543 Remdesivir small molecule DB14761 Details
D544 Venglustat small molecule DB14966 Details
D545 Abrocitinib small molecule DB14973 Details
D546 Ursolic acid small molecule DB15588 Details