Therapeutic Target Details
| Target ID: | T04 |
| Target Name: | Peroxisome proliferator-activated receptor gamma |
| Synonyms: | NR1C3; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; PPAR-gamma |
| GENE: | PPARG |
| Action: | AGONIST; MODULATOR; PARTIAL AGONIST; ANTAGONIST |
| Class: | Target is a single protein chain |
| UniProtKB ID: | P37231 |
| Entry Name: | PPARG_HUMAN |
| Related Drugs: | Pioglitazone Hydrochloride; Rosiglitazone Maleate; Troglitazone; Balsalazide Disodium; Mesalamine; Olsalazine Sodium; Ave0847; Db959; Clx-0921; Netoglitazone; Farglitazar; Naveglitazar; Oms405; Mk-0533; Mbx-2044; Int131; Atx08-001; Efatutazone Hydrochloride; Arhalofenate; Etalocib; Imiglitazar; Aleglitazar; Muraglitazar; Tesaglitazar; Balaglitazone; Rivoglitazone; Bardoxolone Methyl; Mk-0767; Saroglitazar; Leriglitazone |
| Mechanism: | Peroxisome proliferator-activated receptor gamma agonist; Peroxisome proliferator-activated receptor gamma modulator; Peroxisome proliferator-activated receptor gamma partial agonist; Peroxisome proliferator-activated receptor gamma antagonist |
| Reference (PMIDs): | 11043571; 11569941; 11698662; 12898466; 1438286; 15059948; 15120604; 15219816; 15824083; 16125538; 16314690; 16628256; 17884441; 18077625; 18474944; 18511262; 18544567; 19452630; 19507861; 19708827; 20151072; 20932114; 21492364; 22404217; 23294830; 23388479; 23594962; 23686684; 23721199; 24524207; 25926748; 26171220; 33273703; 34078742; 3542979; 9830009 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D135 | Lenalidomide | small molecule | DB00480 | Details | |||
| D150 | Lercanidipine | small molecule | DB00528 | Details | |||
| D159 | Cephalexin | small molecule | DB00567 | Details | |||
| D160 | Propranolol | small molecule | DB00571 | Details | |||
| D196 | Tobramycin | small molecule | DB00684 | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0135 | DB00480 | approved | small molecule | Lenalidomide | Details | |
| R0150 | DB00528 | approved; investigational | small molecule | Lercanidipine | Details | |
| R0159 | DB00567 | approved; investigational; vet_approved | small molecule | Cephalexin | Details | |
| R0160 | DB00571 | approved; investigational | small molecule | Propranolol | Details | |
| R0196 | DB00684 | approved; investigational | small molecule | Tobramycin | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000173 | CHEMBL6 | Small molecule | INDOMETHACIN | 357.79 | C19H16ClNO4 | ACID | Details |
| B000666 | CHEMBL408 | Small molecule | TROGLITAZONE | 441.55 | C24H27NO5S | NEUTRAL | Details |
| B001529 | CHEMBL7002 | Small molecule | CIGLITAZONE | 333.45 | C18H23NO3S | NEUTRAL | Details |
| B001564 | CHEMBL28 | Small molecule | APIGENIN | 270.24 | C15H10O5 | NEUTRAL | Details |
| B001763 | CHEMBL269277 | Small molecule | BETULINIC ACID | 456.71 | C30H48O3 | ACID | Details |
| B002453 | CHEMBL7594 | Small molecule | 304.47 | C20H32O2 | ACID | Details | |
| B002725 | CHEMBL7550 | Small molecule | L-158809 | 409.5 | C24H23N7 | ACID | Details |
| B002994 | CHEMBL457 | Small molecule | GEMFIBROZIL | 250.34 | C15H22O3 | ACID | Details |
| B004361 | CHEMBL8659 | Small molecule | OLEIC ACID | 282.47 | C18H34O2 | ACID | Details |
| B004370 | CHEMBL8739 | Small molecule | LINOLENIC ACID | 278.44 | C18H30O2 | ACID | Details |
| Article ID | PMID | Source | Title |
|---|