| Outcome Measures: |
Primary: Hba1c change, HbA1c group difference at 6 months, 6 months, 9 months, 12 months|Proportions of patients with significant HbA1c change, Proportions of patients undergoing a reduction equal or higher than 0.5% as compared with baseline levels during the follow up, Baseline, 3 months, 6 months, 9 months, 12 months, 18 months | Secondary: Weight Change, Baseline, 6 months, 18 months|BMI Change, Baseline, 6 months, 18 months|Waist circumference change, Baseline, 6 months, 18 months|Blood pressure change, Baseline, 6 months, 18 months|Fasting glycemia change, Baseline, 6 months, 18 months|Post-prandial glycemia change, Baseline, 6 months, 18 months|C-peptide change, Baseline, 6 months, 18 months|Change in total daily insulin dose, Baseline, 6 months, 18 months|Change in lipide profile, Difference between groups in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, Baseline, 6 months, 18 months|Change in eGFR, Baseline, 6 months, 18 months|Diabetes treatment satisfaction, In order to measure satisfaction with diabetes treatment regimens, we used the self-reported Diabetes Treatment Satisfaction Questionnaire. This instrument aims to assess levels of satisfaction in subjects using different treatment strategies. The questionnaire consists of eight questions: six questions addresses general satisfaction with a score from 0 to 6 for each question (0 = worst), that has to be computed in a total score ranging from 0 (=worst) to 36 (=best); among the remaining two questions, which has to be computed separately as two subscales, one concerns the perception of hyperglycemic events and another the perception of hypoglycemic events, both with a score from 0 (none of the time) to 6 (most of the time)., Baseline, 6 months, 18 months
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