| Outcome Measures: |
Primary: Glomerular Filtration Rate (GFR) in ml/Min, Calculated from urinary and plasma inulin concentrations, GFR in ml/min, 12 weeks|Effective Renal Plasma Flow (ERPF) in ml/Min, Calculated from urinary and plasma para-aminohippurate concentrations, ERPF in ml/min, 12 weeks | Secondary: Fractional Excretion of Sodium in % of Filtered Sodium, Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of sodium. Fractional excretion in % of filtered sodium, 12 weeks|Fractional Excretion of Potassium in % of Filtered Potassium, Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of potassium. Fractional excretion in % of filtered potassium, 12 weeks|Fractional Excretion of Glucose in % of Filtered Glucose, Calculated fractional excretions with measured GFR (see above) and urinary and plasma concentrations of glucose. Fractional excretion in % of filtered glucose, 12 weeks|Urinary Albumin-Creatinine Ratio in mg/mmol, Calculated from measured urinary albumin and creatinin concentrations, in mg/mmol, 12 weeks|Neutrophil Gelatinase-associated Lipocalin (NGAL), NGAL (ng/mmoll) measured in urine as a marker of renal damage, 12 weeks|Kidney Injury Molecule-1 (KIM-1) in ng/mmol, KIM-1 (ng/mmol) measured in urine as a marker of renal damage, 12 weeks | Other: Body Weight, Measured in kilograms, 12 weeks|Systolic Blood Pressure, Blood pressure will be measured using an automated oscillometric blood pressure device (Dinamap®) in mmHg, 12 weeks
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