| Outcome Measures: |
Primary: Prevalence of renal response (if dialysis not mandatory at baseline: strata 1); Prevalence of patients free of dialysis (if dialysis required at baseline; strata 2), * renal response is defined by creatinine≤ 170 µmol/l and/or DFG (modified MDRD) ≥ 40 ml/min/1.73m2 * the absence of any dialysis requirement will be defined by an eDFG \> 15 ml/min/1.73 m2, 15 days after the last hemodialysis session, 3 months after randomization | Secondary: Improvement in renal function, * DFG (modified MDRD) * hemodialysis requirement, after 1 cycle of chemotherapy, at the end of chemotherapy, at 6 months and 1 year|Hematological response, Partial Response (PR) Very Good Partial Response (VGPR) Complete Response (CR), after 1 and 3 courses, at the end of chemotherapy and at 1 year|Progression free survival (PFS), Time to progression, relapse or death from randomization, 4 years|Time to treatment Failure (TTF), Time from randomization to progression, relapse, non scheduled hematological treatment or death, 4 years|Overall survival (OS), Time to death from randomization, 4 years
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