| Outcome Measures: |
Primary: Change from Baseline in metagenomic analysis based on rRNA 16S gene, Metagenomic analysis based on rRNA 16S gene will be performed by Novogene on Illumina platform (Hong Kong, China), Each patients will be analyzed at baseline and after 12 weeks|Change from Baseline of total bacterial load, Absolute quantification of total bacterial load in the original sample using real-Time quantitative PCR, Each patients will be analyzed at baseline and after 12 weeks | Secondary: Fasting glucose, Fasting glucose measured in a fasting morning blood sample, baseline and 12 week|Glycated Haemoglobin, HbA1c in a fasting measured in a morning blood sample, baseline and 12 week|Renal function, Using creatinine measured in a fasting morning blood sample and estimated by eGFR (calculated with the CDK-EPI formula), baseline and 12 week|Albumin excretion, Measured by urinary albumin/creatinine ratio, baseline and 12 week|Total cholesterol, Total cholesterol measured in a fasting morning blood sample, baseline and 12 week|HDL cholesterol, HDL cholesterol measured in a fasting morning blood sample, baseline and 12 week|Triglycerides, Triglycerides measured in a fasting morning blood sample, baseline and 12 week
|
