| Outcome Measures: |
Primary: Symptom score in response to insulin-induced hypoglycaemia, Symptom scores (autonomic, neuroglycopenic and general) measured during hyperinsulinemic hypoglycaemic glucose clamps. This questionnaire consists of 18 symptoms, which can be scored between 0 (none) to 6 (severe). Total scores range between 0 and 108, the higher the score, the more symptoms patients have during and after hypoglycemia., 45 minutes | Secondary: Counterregulatory hormone responses to insulin-induced hypoglycaemia, (nor)adrenaline, glucagon, insulin, growth hormone and cortisol responses to hypoglycaemia measured during hyperinsulinemic hypoglycaemic glucose clamps, 45 minutes|Time until glycaemic recovery from hypoglycaemia, measured during hyperinsulinemic hypoglycaemic glucose clamps, 45 minutes|Maximal glucose excursion post-hypoglycaemia, Maximal glucose level (mmol/l) measured during the 90 minutes after ending the hypoglycaemic phase of the clamp (during restoration of euglycaemia), 45 minutes|Time until glucose peak post-hypoglycaemia, measured during hyperinsulinemic hypoglycaemic glucose clamps, 45 minutes|Area under the glucose concentration curve post-hypoglycaemia, measured during hyperinsulinemic hypoglycaemic glucose clamps, 45 minutes|Number of severe hypoglycaemic events during follow-up, measured during follow-up, 16 weeks|Number of nocturnal hypoglycaemic events during follow-up, measured during follow-up, 16 weeks|Number of any hypoglycaemic events during follow-up, measured during follow-up, 16 weeks|Time spent under hypoglycaemic conditions measured by glucose sensor monitoring, measured during follow-up, 2 weeks|Glucose variability as measured by glucose sensor monitoring, measured during follow-up, 2 weeks | Other: Inflammatory/atherogenic phenotype of circulating monocytes from the participating patients, measured during hyperinsulinemic hypoglycaemic glucose clamps, 45 minutes
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