| Trial ID: | L2090 |
| Source ID: | NCT01931982
|
| Associated Drug: |
Victoza
|
| Title: |
Effect of Glucagon-like Peptide 1 (GLP-1) on Microvascular Myocardial Function in Patients With Type 2 Diabetes.
|
| Acronym: |
EGOFIP
|
| Status: |
COMPLETED
|
| Study Results: |
NO
|
| Results: |
|
| Conditions: |
Type 2 Diabetes|Microvascular Dysfunction
|
| Interventions: |
DRUG: Victoza
|
| Outcome Measures: |
Primary: Change in coronary flow reserve (CFR), CFR can be reliably assessed non-invasively by trans-thoracic Doppler flow echocardiography of the left anterior descending artery with a success rate of over 90% even in an obese population with a relative poor acoustic window. CFR is the ratio of flow during stress to during rest., CFR is measured at baseline and after 10 weeks of intervention | Secondary: Change in Endothelial function:, Measurement of Peripheral Arterial Tone, with the use of the commercially available machine (Endo-PAT2000®) assesses the control of digital vascular tone by the sympathetic nervous system and nitric oxide (NO)., Endothelial function is measured at baseline and after 10 weeks of intervention | Other: Changes in HbA1c, Measurements at baseline and after 10 weeks of intervention|Change in fasting C-peptide, C-peptide is measured at baseline and after 10 weeks of intervention|Change in fasting insulin, Fasting insulin is measured at baseline and after 10 weeks of intervention|Change in fasting glucose, Fasting glucose is measured at baseline and after 10 weeks of intervention|Change in weight, Weight is measured at baseline and after 10 weeks of intervention|Change in waist circumference, Waist circumference is measured at baseline and after 10 weeks of intervention
|
| Sponsor/Collaborators: |
Sponsor: Bispebjerg Hospital
|
| Gender: |
ALL
|
| Age: |
ADULT, OLDER_ADULT
|
| Phases: |
PHASE4
|
| Enrollment: |
20
|
| Study Type: |
INTERVENTIONAL
|
| Study Designs: |
Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
|
| Start Date: |
2013-05
|
| Completion Date: |
2014-04
|
| Results First Posted: |
|
| Last Update Posted: |
2014-06-25
|
| Locations: |
Bispebjerg Hospital, Copenhagen, Capital region, 2400, Denmark
|
| URL: |
https://clinicaltrials.gov/show/NCT01931982
|
