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Clinical Trial Details

Trial ID: L3738
Source ID: NCT03959501
Associated Drug: Dapagliflozin 10 Mg
Title: Metabolic Responses of Dapagliflozin vs Sitagliptin in T2DM Patients Inadequately Controlled With Insulin Therapy
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Type 2 Diabetes|Ketonemia
Interventions: DRUG: Dapagliflozin 10 mg|DRUG: Sitagliptin 100mg
Outcome Measures: Primary: Change in serum ketone levels after treatment, Change in serum ketone levels before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks | Secondary: Change in fasting glucose, Change in fasting plasma glucose before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in glycated haemoglobin, Change in glycated haemoglobin before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in body weight, Change in body weight before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in blood pressure, Change in systolic and diastolic blood pressure before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in fasting lipid, Change in fasting lipid before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in free fatty acid levels, Change in free fatty acid levels before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in fasting glucagon levels, Change in fasting glucagon levels before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks|Change in homeostasis model assessment 2 steady-state beta-cell function, Change in homeostasis model assessment 2 steady-state beta-cell function before and after treatment with either dapagliflozin or sitagliptin for 24 weeks, 24 weeks
Sponsor/Collaborators: Sponsor: The University of Hong Kong
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 60
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Start Date: 2017-08-16
Completion Date: 2020-10-16
Results First Posted:
Last Update Posted: 2021-04-29
Locations: L2 Diabetes Centre, Queen Mary Hospital, Hong Kong, Hong Kong
URL: https://clinicaltrials.gov/show/NCT03959501