| Outcome Measures: |
Primary: Urine will be collected over a 24 h period for determination of renal glucose clearance, total protein, and measurement of total glucose excreted in urine, on Days -1, 1, 4 and 10|Blood samples for serum glucose and creatinine will be collected, on Days -1, 1, 4 and 10 at selected timepoints|Blood and urine PK samples, on Days 1, 4, 10|Iohexol PK blood & urine samples for GFR assessment, on Day -12 to -5 | Secondary: AEs, vital signs, scr, Days -1, 1, 4-11, discharge|physical exams, scr, Days -12 to -5, -1, discharge|ECGs, scr, Days,-1, 4, 7, discharge|clinical labs, scr, Day -1, 1, 4, 6, 8, 10, discharge|The following urine/serum safety parameters will be assessed: sodium, potassium, magnesium, phosphorus, calcium, and total protein (urine only), on Days -1, 1, 4 and 10
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| Locations: |
Advanced Clinical Research Institute, Anaheim, California, 92801, United States|Elite Research Institute, Miami, Florida, 33169, United States|Prism Research, St. Paul, Minnesota, 55114, United States|Dgd Research, Inc., San Antonio, Texas, 78229, United States
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