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Clinical Trial Details

Trial ID: L4266
Source ID: NCT02180334
Associated Drug: Mosapride Citrate
Title: The Effect of Combination of Mosapride and DPP-4 Inhibitor on Plasma Concentration of Incretin Hormones
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Mosapride citrate|DRUG: Linagliptin|DRUG: Acetaminophen (paracetamol)
Outcome Measures: Primary: Area under the curve (AUC) of plasma total GLP-1 levels, AUC of plasma total GLP-1 levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured) | Secondary: Area under the curve (AUC) of plasma total GIP levels, AUC of plasma total GIP levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|Area under the curve (AUC) of plasma glucose levels, AUC of plasma glucose levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|Area under the curve (AUC) of plasma insulin levels, AUC of plasma insulin levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|Area under the curve (AUC) of plasma C-peptide levels, AUC of plasma C-peptide levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|Area under the curve (AUC) of serum triglyceride levels, AUC of serum triglyceride levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|Area under the curve (AUC) of serum nonesterified fatty acid (NEFA) levels, AUC of serum NEFA levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|Area under the curve (AUC) of plasma active GLP-1 levels, AUC of plasma active GLP-1 levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured) | Other: Area under the curve (AUC) of plasma paracetamol levels, AUC of plasma paracetamol levels during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|The peak concentration of plasma paracetamol, The peak concentration of plasma paracetamol during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)|The time to peak concentration of plasma paracetamol, The time to peak concentration of plasma paracetamol during MMTT, 0, 15, 30, 60, 90, 120, 150, 180 min after taking mixed meal (manufactured)
Sponsor/Collaborators: Sponsor: Seoul National University Hospital | Collaborators: Daewoong Pharmaceutical Co. LTD.
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 12
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Start Date: 2014-07
Completion Date: 2015-04
Results First Posted:
Last Update Posted: 2017-11-29
Locations: Seoul National University Hospital, Seoul, 110-744, Korea, Republic of
URL: https://clinicaltrials.gov/show/NCT02180334