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Clinical Trial Details

Trial ID: L0884
Source ID: NCT01870011
Associated Drug: Desflurane Balanced Anesthesia
Title: A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial
Acronym:
Status: COMPLETED
Study Results: NO
Results:
Conditions: End Stage Renal Disease
Interventions: DRUG: Desflurane balanced anesthesia|DRUG: Propofol total intravenous anesthesia
Outcome Measures: Primary: The difference in inflammatory markers of recipients between groups during and after renal transplantation (CRP, WBC differential count, IL-6, TGF-β), 1. Kidney donor: Inflammatory markers are evaluated immediately after anesthesia induction, right before kidney extraction and 1 hour after kidney extraction 2. Kidney recipient: (1) Inflammatory markers: Immediately after anesthesia induction, 2 and 24 hours after reperfusion (2) Renal function markers: Before anesthesia, 2 hours after reperfusion, immediate post-op, 24 and 48 hours postoperatively, Inflammatory markers are evelauted immediately after anesthesia induction, right before kidney extraction and 1 hour after kidney extraction | Secondary: The difference in renal function of kidney recipients between groups after renal transplantation (BUN/Cr, cystatin C, NGAL), 1. Kidney donor: Inflammatory markers are evaluated immediately after anesthesia induction, right before kidney extraction and 1 hour after kidney extraction 2. Kidney recipient: (1) Inflammatory markers: Immediately after anesthesia induction, 2 and 24 hours after reperfusion (2) Renal function markers: Before anesthesia, 2 hours after reperfusion, immediate post-op, 24 and 48 hours postoperatively, immediately after anesthesia induction, right before kidney extraction and 1 hour after kidney extraction | Other: The difference in global oxidative stress markers of recipients between groups during and after renal transplantation (Free Oxygen Radicals Testing, Free Oxygen Radial Defense), 1. Kidney donor: Inflammatory markers are evaluated immediately after anesthesia induction, right before kidney extraction and 1 hour after kidney extraction 2. Kidney recipient: (1) Inflammatory markers: Immediately after anesthesia induction, 2 and 24 hours after reperfusion (2) Renal function markers: Before anesthesia, 2 hours after reperfusion, immediate post-op, 24 and 48 hours postoperatively, changes of Global oxidative stress markers from Immediately after anesthesia induction to 2 hours after reperfusion
Sponsor/Collaborators: Sponsor: Yonsei University
Gender: ALL
Age: ADULT, OLDER_ADULT
Phases: PHASE4
Enrollment: 6
Study Type: INTERVENTIONAL
Study Designs: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Start Date: 2013-12
Completion Date: 2014-11
Results First Posted:
Last Update Posted: 2016-08-17
Locations: Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, 120-752, Korea, Republic of
URL: https://clinicaltrials.gov/show/NCT01870011

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D349 Desflurane small molecule DB01189 Details
D232 Propofol small molecule DB00818 Details