Bioactive Compound Details
| Compound ID: | B1277553 |
| Source ID: | CHEMBL1946170 |
| Source Type: | Small molecule |
| Compound Name: | REGORAFENIB |
| Synonyms: | BAY 73-4506|BAY 73-4506 monohydrate|BAY-73-4506|BAY-734506|Regorafenib|Regorafenib|Regorafenib|Regorafenib|Regorafenib|Regorafenib|Regorafenib|Regorafenib|Regorafenib|Regorafenib anhydrous|Regorafenib hydrate|Regorafenib hydrate|Regorafenib monohydrate|Stivarga |
| Molecular Formula: | C21H15ClF4N4O3 |
| SMILES: | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |