Bioactive Compound Details
| Compound ID: | B1376145 |
| Source ID: | CHEMBL2103875 |
| Source Type: | Small molecule |
| Compound Name: | TRAMETINIB |
| Synonyms: | GSK-1120212|GSK1120212|JTP 74057|JTP-74057|Mekinist|TMT-212|Tmt212|TMT212|Trametinib|Trametinib|Trametinib|Trametinib|Trametinib|Trametinib |
| Molecular Formula: | C26H23FIN5O4 |
| SMILES: | CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |