Bioactive Compound Details
| Compound ID: | B1377987 |
| Source ID: | CHEMBL2105717 |
| Source Type: | Small molecule |
| Compound Name: | CABOZANTINIB |
| Synonyms: | BMS-907351|XL-184|BMS-907351 FREE BASE|Cabometyx|Cabozantinib|Cabozantinib|Cabozantinib|Cabozantinib|Cabozantinib|Cabozantinib|Cometriq|XL-184 FREE BASE|XL184 |
| Molecular Formula: | C28H24FN3O5 |
| SMILES: | COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |