Bioactive Compound Details
| Compound ID: | B1420377 |
| Source ID: | CHEMBL2146883 |
| Source Type: | Small molecule |
| Compound Name: | COBIMETINIB |
| Synonyms: | Cobimetinib|Cobimetinib|Cobimetinib|Cobimetinib|Cobimetinib|Cobimetinib|Cotellic|Gdc 0623|Gdc 0973|Gdc-0623|GDC-0973|RG 7420|Rg-7420|RG-7420|Rg-7421|RG7420|Xl 518|XL-518|Xl518 |
| Molecular Formula: | C21H21F3IN3O2 |
| SMILES: | O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1 |
| Molecular Species: | BASE |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |