Bioactive Compound Details
| Compound ID: | B1748986 |
| Source ID: | CHEMBL3264002 |
| Source Type: | Small molecule |
| Compound Name: | AVUTOMETINIB |
| Synonyms: | RG-7304|Avutometinib|Avutometinib|Avutometinib|Avutometinib|Avutometinib|CH-5126766|CH5126766|CKI-27|R-7304|Rg-7304|Ro 5126766|Ro-5126766|VS-6766 |
| Molecular Formula: | C21H18FN5O5S |
| SMILES: | CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |