Bioactive Compound Details
| Compound ID: | B2089491 |
| Source ID: | CHEMBL3813873 |
| Source Type: | Small molecule |
| Compound Name: | PEXIDARTINIB |
| Synonyms: | CML-261|Pexidartinib|Pexidartinib|Pexidartinib|Pexidartinib|Pexidartinib|Plx-3397|PLX-3397|PLX3397 |
| Molecular Formula: | C20H15ClF3N5 |
| SMILES: | FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |