Bioactive Compound Details
| Compound ID: | B699032 |
| Source ID: | CHEMBL1236682 |
| Source Type: | Small molecule |
| Compound Name: | REFAMETINIB |
| Synonyms: | BAY 869766|BAY 8697661|Bay-86-9766|BAY-86-9766|BAY-869766|BAY-8697661|BAY86-9766|BAY869766|BAY8697661|RDEA 119|RDEA-119|Rdea119|Refametinib|Refametinib |
| Molecular Formula: | C19H20F3IN2O5S |
| SMILES: | COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |