Research Articles
Research articles concerning CKD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in CKDdb are presented with knowledge graphs.
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Diabetes mellitus148 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00001 | 10084598 | J Clin Endocrinol Metab | The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree. | 1999 | Details |
| A00002 | 10199785 | J Clin Endocrinol Metab | Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. | 1999 | Details |
| A00003 | 10331426 | Diabetes | A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. | 1999 | Details |
| A00006 | 10525667 | Diabetologia | Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. | 1999 | Details |
| A00007 | 10545530 | J Clin Invest | Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. | 1999 | Details |
| A00008 | 10545531 | J Clin Invest | Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. | 1999 | Details |
| A00009 | 10545951 | Nat Genet | Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. | 1999 | Details |
| A00010 | 10700186 | Nat Genet | The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. | 2000 | Details |
| A00011 | 10720052 | J Clin Endocrinol Metab | HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients. | 2000 | Details |
| A00013 | 10843190 | J Clin Endocrinol Metab | Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree. | 2000 | Details |
| A00015 | 10902787 | J Clin Endocrinol Metab | Alterations in nitric oxide/cyclic-GMP pathway in nondiabetic siblings of patients with type 2 diabetes. | 2000 | Details |
| A00016 | 10958757 | Hum Mol Genet | Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. | 2000 | Details |
| A00017 | 10973253 | Nat Genet | The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. | 2000 | Details |
| A00019 | 11030756 | Hum Mol Genet | Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. | 2000 | Details |
| A00020 | 11032783 | Am J Hum Genet | The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. | 2000 | Details |
| A00021 | 11032784 | Am J Hum Genet | The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. | 2000 | Details |
| A00022 | 11067779 | Am J Hum Genet | Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. | 2001 | Details |
| A00023 | 11130726 | Nature | Attenuation of FGF signalling in mouse beta-cells leads to diabetes. | 2001 | Details |
| A00024 | 11158011 | J Clin Endocrinol Metab | Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes. | 2001 | Details |
| A00025 | 11443197 | J Clin Endocrinol Metab | Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? | 2001 | Details |
| A00026 | 11473060 | Diabetes | New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes. | 2001 | Details |
| A00027 | 11533494 | Science | Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. | 2001 | Details |
| A00028 | 11558907 | J Hum Genet | Single nucleotide polymorphisms of the resistin (RSTN) gene. | 2001 | Details |
| A00030 | 11723072 | Diabetes | A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese. | 2001 | Details |
| A00036 | 11904371 | Proc Natl Acad Sci U S A | HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community. | 2002 | Details |
| A00037 | 11916952 | Diabetes | Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. | 2002 | Details |
| A00038 | 12045211 | Hum Mol Genet | Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study. | 2002 | Details |
| A00039 | 12118251 | Nat Genet | Digenic inheritance of severe insulin resistance in a human pedigree. | 2002 | Details |
| A00040 | 12161522 | J Clin Endocrinol Metab | Nonsense and missense mutations in the human hepatocyte nuclear factor-1 beta gene (TCF2) and their relation to type 2 diabetes in Japanese. | 2002 | Details |
| A00043 | 12629116 | J Clin Endocrinol Metab | Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population. | 2003 | Details |
| A00044 | 12679424 | J Clin Endocrinol Metab | A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. | 2003 | Details |
| A00045 | 12719374 | Hum Mol Genet | Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. | 2004 | Details |
| A00046 | 12727978 | J Clin Endocrinol Metab | A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13. | 2003 | Details |
| A00048 | 12783844 | Hum Mol Genet | Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case - control study. | 2004 | Details |
| A00050 | 12874106 | Hum Mol Genet | A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. | 2004 | Details |
| A00051 | 12915642 | J Clin Endocrinol Metab | Efficacy of glyburide/metformin tablets compared with initial monotherapy in type 2 diabetes. | 2003 | Details |
| A00052 | 12970316 | J Clin Endocrinol Metab | Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. | 2003 | Details |
| A00054 | 1357346 | Lancet | Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. | 1992 | Details |
| A00055 | 1360036 | Lancet | Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. | 1992 | Details |
| A00056 | 1397713 | Diabetes | Glucokinase and NIDDM. A candidate gene that paid off. | 1992 | Details |
| A00058 | 14960743 | N Engl J Med | Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. | 2004 | Details |
| A00060 | 15001634 | J Clin Endocrinol Metab | The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes. | 2004 | Details |
| A00062 | 15070960 | J Clin Endocrinol Metab | Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. | 2004 | Details |
| A00063 | 15126514 | J Clin Endocrinol Metab | The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. | 2004 | Details |
| A00064 | 15126519 | J Clin Endocrinol Metab | The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. | 2004 | Details |
| A00065 | 15166380 | Science | A family with severe insulin resistance and diabetes due to a mutation in AKT2. | 2004 | Details |
| A00067 | 15472205 | J Clin Endocrinol Metab | Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes. | 2004 | Details |
| A00068 | 15808156 | Am J Ophthalmol | Persistent diabetic macular edema is associated with elevated hemoglobin A1c. | 2005 | Details |
| A00069 | 1587533 | Hum Genet | Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth. | 1992 | Details |
| A00070 | 15924147 | Nat Med | Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. | 2005 | Details |
| A00071 | 15940393 | J Hum Genet | Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. | 2005 | Details |
| A00072 | 15980866 | Nat Med | Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. | 2005 | Details |
| A00073 | 16025115 | Nat Genet | Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. | 2005 | Details |
| A00074 | 16034410 | Nature | Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. | 2005 | Details |
| A00075 | 1607076 | Diabetes | NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene. | 1992 | Details |
| A00076 | 16142453 | Hum Genet | Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns. | 2006 | Details |
| A00079 | 16415884 | Nat Genet | Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. | 2006 | Details |
| A00080 | 16607460 | J Hum Genet | No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population. | 2006 | Details |
| A00082 | 16775236 | N Engl J Med | Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. | 2006 | Details |
| A00083 | 16885549 | N Engl J Med | Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. | 2006 | Details |
| A00085 | 17066296 | Hum Genet | Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors. | 2007 | Details |
| A00086 | 17179727 | Hum Hered | Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q. | 2007 | Details |
| A00087 | 17206141 | Nat Genet | Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. | 2007 | Details |
| A00088 | 17245407 | Eur J Hum Genet | TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden. | 2007 | Details |
| A00089 | 17273962 | Am J Hum Genet | Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. | 2007 | Details |
| A00090 | 17293876 | Nature | A genome-wide association study identifies novel risk loci for type 2 diabetes. | 2007 | Details |
| A00091 | 17340123 | Diabetologia | Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. | 2007 | Details |
| A00092 | 17460697 | Nat Genet | A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. | 2007 | Details |
| A00093 | 17463246 | Science | Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. | 2007 | Details |
| A00094 | 17463248 | Science | A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. | 2007 | Details |
| A00095 | 17463249 | Science | Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. | 2007 | Details |
| A00096 | 17470138 | Clin Genet | Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City. | 2007 | Details |
| A00097 | 17503332 | Am J Hum Genet | Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. | 2007 | Details |
| A00098 | 17603484 | Nat Genet | Common variants in WFS1 confer risk of type 2 diabetes. | 2007 | Details |
| A00099 | 17603485 | Nat Genet | Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. | 2007 | Details |
| A00100 | 17609304 | J Clin Endocrinol Metab | Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese. | 2007 | Details |
| A00102 | 17652184 | Mol Endocrinol | Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. | 2008 | Details |
| A00103 | 17671651 | J Clin Invest | Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. | 2007 | Details |
| A00106 | 18008060 | Diabetologia | The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. | 2008 | Details |
| A00107 | 18025464 | Proc Natl Acad Sci U S A | Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. | 2008 | Details |
| A00108 | 18097733 | J Hum Genet | Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. | 2008 | Details |
| A00109 | 18231124 | Eur J Hum Genet | HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. | 2008 | Details |
| A00110 | 18323454 | Science | Hepatic glucose sensing via the CREB coactivator CRTC2. | 2008 | Details |
| A00111 | 18364377 | J Clin Endocrinol Metab | The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. | 2008 | Details |
| A00112 | 18477659 | J Clin Endocrinol Metab | Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. | 2008 | Details |
| A00114 | 18602895 | Biochem Biophys Res Commun | Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes. | 2008 | Details |
| A00115 | 18711366 | Nat Genet | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. | 2009 | Details |
| A00116 | 18711367 | Nat Genet | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. | 2009 | Details |
| A00118 | 18952314 | Trends Genet | Type 2 diabetes: new genes, new understanding. | 2009 | Details |
| A00119 | 19020323 | N Engl J Med | Genotype score in addition to common risk factors for prediction of type 2 diabetes. | 2008 | Details |
| A00120 | 19020324 | N Engl J Med | Clinical risk factors, DNA variants, and the development of type 2 diabetes. | 2008 | Details |
| A00122 | 19602480 | Hum Mol Genet | Tissue-specific alternative splicing of TCF7L2. | 2010 | Details |
| A00124 | 19639018 | Nat Rev Nephrol | HNF1B-related diabetes triggered by renal transplantation. | 2009 | Details |
| A00125 | 19657112 | N Engl J Med | Sex hormone-binding globulin and risk of type 2 diabetes in women and men. | 2009 | Details |
| A00127 | 19933169 | Hum Mol Genet | Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. | 2010 | Details |
| A00128 | 20016592 | Nature | Parental origin of sequence variants associated with complex diseases. | 2010 | Details |
| A00129 | 20085713 | Am J Hum Genet | Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. | 2010 | Details |
| A00130 | 20118932 | Nat Genet | A map of open chromatin in human pancreatic islets. | 2010 | Details |
| A00132 | 20360734 | Nature | Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. | 2010 | Details |
| A00134 | 20574426 | J Hum Genet | The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. | 2011 | Details |