Research Article Details
| Article ID: | A00109 |
| PMID: | 18231124 |
| Source: | Eur J Hum Genet |
| Title: | HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. |
| Abstract: | Recently, the hematopoietically expressed homeobox (HHEX) gene, encoding a transcription factor, was identified in a large genome-wide scan in French individuals as a type 2 diabetes (T2D)-susceptibility locus. We aimed to check whether this finding could be replicated in a Dutch T2D cohort. Two common variants (rs7923837 and rs1111875) located near the HHEX gene were genotyped in 501 unrelated T2D patients and in 920 healthy controls. The major alleles of both variants were overrepresented in T2D cases compared with controls (66.7 vs 64.1%, P=0.16 for rs7923837 and 64.6 vs 60.4%, P=0.027 for rs1111875). For both polymorphisms, the risk for T2D was significantly increased in carriers of the major alleles (rs7923837: odds ratio (OR): 1.57, 95% confidence interval (CI): 1.08-2.27, P=0.017 and rs1111875: OR: 1.68, 95% CI: 1.19-2.35, P=0.003). The haplotype analysis did not reveal a risk haplotype that provided stronger evidence for association with T2D than each variant individually. Assuming a dominant genetic model, the population-attributable risks for diabetes due to the at-risk alleles of rs7923837 and rs1111875 were estimated to be 33 and 36%, respectively. These data provide evidence that variants near the HHEX gene contribute to the risk of T2D in a Dutch population. |
| DOI: | 10.1038/sj.ejhg.5202008 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D001 | Leuprolide | small molecule | DB00007 | Details | |||
| D002 | Goserelin | small molecule | DB00014 | Details | |||
| D003 | Cetrorelix | small molecule | DB00050 | Details | |||
| D004 | Pyridoxal phosphate | small molecule | DB00114 | Details | |||
| D005 | Histidine | small molecule | DB00117 | Details | |||
| D006 | Phenylalanine | small molecule | DB00120 | Details | |||
| D007 | Biotin | small molecule | DB00121 | Details | |||
| D008 | Choline | small molecule | DB00122 | Details | |||
| D009 | L-Lysine | small molecule | DB00123 | Details | |||
| D010 | Arginine | small molecule | DB00125 | Details | |||
| D011 | Ascorbic acid | small molecule | DB00126 | Details | |||
| D012 | Aspartic acid | small molecule | DB00128 | Details | |||
| D013 | Ornithine | small molecule | DB00129 | Details | |||
| D014 | L-Glutamine | small molecule | DB00130 | Details | |||
| D015 | Serine | small molecule | DB00133 | Details | |||
| D016 | Methionine | small molecule | DB00134 | Details | |||
| D017 | Tyrosine | small molecule | DB00135 | Details | |||
| D018 | Calcitriol | small molecule | DB00136 | Details | |||
| D019 | Lutein | small molecule | DB00137 | Details | |||
| D020 | Riboflavin | small molecule | DB00140 | Details | |||
| D021 | Glutamic acid | small molecule | DB00142 | Details | |||
| D022 | Phosphatidyl serine | small molecule | DB00144 | Details | |||
| D023 | Glycine | small molecule | DB00145 | Details | |||
| D024 | Calcifediol | small molecule | DB00146 | Details | |||
| D025 | Pyridoxal | small molecule | DB00147 | Details | |||
| D026 | Creatine | small molecule | DB00148 | Details | |||
| D027 | Leucine | small molecule | DB00149 | Details | |||
| D028 | Tryptophan | small molecule | DB00150 | Details | |||
| D029 | Cysteine | small molecule | DB00151 | Details | |||
| D030 | Thiamine | small molecule | DB00152 | Details | |||
| D031 | Ergocalciferol | small molecule | DB00153 | Details | |||
| D032 | Threonine | small molecule | DB00156 | Details | |||
| D033 | Alanine | small molecule | DB00160 | Details | |||
| D034 | Valine | small molecule | DB00161 | Details | |||
| D035 | Vitamin A | small molecule | DB00162 | Details | |||
| D036 | Vitamin E | small molecule | DB00163 | Details | |||
| D037 | Pyridoxine | small molecule | DB00165 | Details | |||
| D038 | Isoleucine | small molecule | DB00167 | Details | |||
| D039 | Cholecalciferol | small molecule | DB00169 | Details | |||
| D040 | Menadione | small molecule | DB00170 | Details | |||
| D041 | Proline | small molecule | DB00172 | Details | |||
| D042 | Pravastatin | small molecule | DB00175 | Details | |||
| D043 | Valsartan | small molecule | DB00177 | Details | |||
| D044 | Ramipril | small molecule | DB00178 | Details | |||
| D045 | Esmolol | small molecule | DB00187 | Details | |||
| D046 | Bortezomib | small molecule | DB00188 | Details | |||
| D047 | Phentermine | small molecule | DB00191 | Details | |||
| D048 | Tramadol | small molecule | DB00193 | Details | |||
| D049 | Fluconazole | small molecule | DB00196 | Details | |||
| D050 | Troglitazone | small molecule | DB00197 | Details | |||
| D051 | Oseltamivir | small molecule | DB00198 | Details | |||
| D052 | Erythromycin | small molecule | DB00199 | Details | |||
| D053 | Caffeine | small molecule | DB00201 | Details | |||
| D054 | Reserpine | small molecule | DB00206 | Details | |||
| D055 | Azithromycin | small molecule | DB00207 | Details | |||
| D056 | Pantoprazole | small molecule | DB00213 | Details | |||
| D057 | Torasemide | small molecule | DB00214 | Details | |||
| D058 | Citalopram | small molecule | DB00215 | Details | |||
| D059 | Moxifloxacin | small molecule | DB00218 | Details | |||
| D060 | Indinavir | small molecule | DB00224 | Details | |||
| D061 | Lovastatin | small molecule | DB00227 | Details | |||
| D062 | Pregabalin | small molecule | DB00230 | Details | |||
| D063 | Nevirapine | small molecule | DB00238 | Details | |||
| D064 | Ranolazine | small molecule | DB00243 | Details | |||
| D065 | Ziprasidone | small molecule | DB00246 | Details | |||
| D066 | Doxycycline | small molecule | DB00254 | Details | |||
| D067 | Clotrimazole | small molecule | DB00257 | Details | |||
| D068 | Metoprolol | small molecule | DB00264 | Details | |||
| D069 | Ropinirole | small molecule | DB00268 | Details | |||
| D070 | Chlorotrianisene | small molecule | DB00269 | Details | |||
| D071 | Topiramate | small molecule | DB00273 | Details | |||
| D072 | Olmesartan | small molecule | DB00275 | Details | |||
| D073 | Theophylline | small molecule | DB00277 | Details | |||
| D074 | Lidocaine | small molecule | DB00281 | Details | |||
| D075 | Pamidronic acid | small molecule | DB00282 | Details | |||
| D076 | Chlorambucil | small molecule | DB00291 | Details | |||
| D077 | Morphine | small molecule | DB00295 | Details | |||
| D078 | Bupivacaine | small molecule | DB00297 | Details | |||
| D079 | Tranexamic acid | small molecule | DB00302 | Details | |||
| D080 | Ertapenem | small molecule | DB00303 | Details | |||
| D081 | Mitomycin | small molecule | DB00305 | Details | |||
| D082 | Chlorthalidone | small molecule | DB00310 | Details | |||
| D083 | Valproic acid | small molecule | DB00313 | Details | |||
| D084 | Acetaminophen | small molecule | DB00316 | Details | |||
| D085 | Piperacillin | small molecule | DB00319 | Details | |||
| D086 | Amitriptyline | small molecule | DB00321 | Details | |||
| D087 | Nitroprusside | small molecule | DB00325 | Details | |||
| D088 | Indomethacin | small molecule | DB00328 | Details | |||
| D089 | Metformin | small molecule | DB00331 | Details | |||
| D090 | Methadone | small molecule | DB00333 | Details | |||
| D091 | Olanzapine | small molecule | DB00334 | Details | |||
| D092 | Atenolol | small molecule | DB00335 | Details | |||
| D093 | Cetirizine | small molecule | DB00341 | Details | |||
| D094 | Diltiazem | small molecule | DB00343 | Details | |||
| D095 | Minoxidil | small molecule | DB00350 | Details | |||
| D096 | Chlorzoxazone | small molecule | DB00356 | Details | |||
| D097 | Clozapine | small molecule | DB00363 | Details | |||
| D098 | Levonorgestrel | small molecule | DB00367 | Details | |||
| D099 | Norepinephrine | small molecule | DB00368 | Details | |||
| D100 | Cidofovir | small molecule | DB00369 | Details | |||
| D101 | Mirtazapine | small molecule | DB00370 | Details | |||
| D102 | Treprostinil | small molecule | DB00374 | Details | |||
| D103 | Dydrogesterone | small molecule | DB00378 | Details | |||
| D104 | Amlodipine | small molecule | DB00381 | Details | |||
| D105 | Triamterene | small molecule | DB00384 | Details | |||
| D106 | Phenylephrine | small molecule | DB00388 | Details | |||
| D107 | Digoxin | small molecule | DB00390 | Details | |||
| D108 | Nimodipine | small molecule | DB00393 | Details | |||
| D109 | Progesterone | small molecule | DB00396 | Details | |||
| D110 | Sorafenib | small molecule | DB00398 | Details | |||
| D111 | Zoledronic acid | small molecule | DB00399 | Details | |||
| D112 | Eszopiclone | small molecule | DB00402 | Details | |||
| D113 | Alprazolam | small molecule | DB00404 | Details | |||
| D114 | Loxapine | small molecule | DB00408 | Details | |||
| D115 | Mupirocin | small molecule | DB00410 | Details | |||
| D116 | Rosiglitazone | small molecule | DB00412 | Details | |||
| D117 | Acetohexamide | small molecule | DB00414 | Details | |||
| D118 | Ampicillin | small molecule | DB00415 | Details | |||
| D119 | Spironolactone | small molecule | DB00421 | Details | |||
| D120 | Methocarbamol | small molecule | DB00423 | Details | |||
| D121 | Zolpidem | small molecule | DB00425 | Details | |||
| D122 | Nitric Oxide | small molecule | DB00435 | Details | |||
| D123 | Ceftazidime | small molecule | DB00438 | Details | |||
| D124 | Trimethoprim | small molecule | DB00440 | Details | |||
| D125 | Betamethasone | small molecule | DB00443 | Details | |||
| D126 | Lansoprazole | small molecule | DB00448 | Details | |||
| D127 | Loratadine | small molecule | DB00455 | Details | |||
| D128 | Imipramine | small molecule | DB00458 | Details | |||
| D129 | Dronabinol | small molecule | DB00470 | Details | |||
| D130 | Montelukast | small molecule | DB00471 | Details | |||
| D131 | Fluoxetine | small molecule | DB00472 | Details | |||
| D132 | Duloxetine | small molecule | DB00476 | Details | |||
| D133 | Chlorpromazine | small molecule | DB00477 | Details | |||
| D134 | Amikacin | small molecule | DB00479 | Details | |||
| D135 | Lenalidomide | small molecule | DB00480 | Details | |||
| D136 | Celecoxib | small molecule | DB00482 | Details | |||
| D137 | Altretamine | small molecule | DB00488 | Details | |||
| D138 | Miglitol | small molecule | DB00491 | Details | |||
| D139 | Cefotaxime | small molecule | DB00493 | Details | |||
| D140 | Zidovudine | small molecule | DB00495 | Details | |||
| D141 | Oxycodone | small molecule | DB00497 | Details | |||
| D142 | Cimetidine | small molecule | DB00501 | Details | |||
| D143 | Ritonavir | small molecule | DB00503 | Details | |||
| D144 | Nitazoxanide | small molecule | DB00507 | Details | |||
| D145 | Vancomycin | small molecule | DB00512 | Details | |||
| D146 | Aminocaproic acid | small molecule | DB00513 | Details | |||
| D147 | Trandolapril | small molecule | DB00519 | Details | |||
| D148 | Metolazone | small molecule | DB00524 | Details | |||
| D149 | Tolnaftate | small molecule | DB00525 | Details | |||
| D150 | Lercanidipine | small molecule | DB00528 | Details | |||
| D151 | Cyclophosphamide | small molecule | DB00531 | Details | |||
| D152 | Ciprofloxacin | small molecule | DB00537 | Details | |||
| D153 | Benazepril | small molecule | DB00542 | Details | |||
| D154 | Propylthiouracil | small molecule | DB00550 | Details | |||
| D155 | Zanamivir | small molecule | DB00558 | Details | |||
| D156 | Bosentan | small molecule | DB00559 | Details | |||
| D157 | Methotrexate | small molecule | DB00563 | Details | |||
| D158 | Cisatracurium | small molecule | DB00565 | Details | |||
| D159 | Cephalexin | small molecule | DB00567 | Details | |||
| D160 | Propranolol | small molecule | DB00571 | Details | |||
| D161 | Atropine | small molecule | DB00572 | Details | |||
| D162 | Clonidine | small molecule | DB00575 | Details | |||
| D163 | Lactulose | small molecule | DB00581 | Details | |||
| D164 | Voriconazole | small molecule | DB00582 | Details | |||
| D165 | Diclofenac | small molecule | DB00586 | Details | |||
| D166 | Doxazosin | small molecule | DB00590 | Details | |||
| D167 | Amiloride | small molecule | DB00594 | Details | |||
| D168 | Labetalol | small molecule | DB00598 | Details | |||
| D169 | Thiopental | small molecule | DB00599 | Details | |||
| D170 | Linezolid | small molecule | DB00601 | Details | |||
| D171 | Cisapride | small molecule | DB00604 | Details | |||
| D172 | Nafcillin | small molecule | DB00607 | Details | |||
| D173 | Chloroquine | small molecule | DB00608 | Details | |||
| D174 | Bisoprolol | small molecule | DB00612 | Details | |||
| D175 | Fluphenazine | small molecule | DB00623 | Details | |||
| D176 | Testosterone | small molecule | DB00624 | Details | |||
| D177 | Efavirenz | small molecule | DB00625 | Details | |||
| D178 | Bacitracin | small molecule | DB00626 | Details | |||
| D179 | Niacin | small molecule | DB00627 | Details | |||
| D180 | Alendronic acid | small molecule | DB00630 | Details | |||
| D181 | Prednisone | small molecule | DB00635 | Details | |||
| D182 | Inulin | small molecule | DB00638 | Details | |||
| D183 | Adenosine | small molecule | DB00640 | Details | |||
| D184 | Simvastatin | small molecule | DB00641 | Details | |||
| D185 | Stavudine | small molecule | DB00649 | Details | |||
| D186 | Trazodone | small molecule | DB00656 | Details | |||
| D187 | Verapamil | small molecule | DB00661 | Details | |||
| D188 | Epinephrine | small molecule | DB00668 | Details | |||
| D189 | Pirenzepine | small molecule | DB00670 | Details | |||
| D190 | Cefixime | small molecule | DB00671 | Details | |||
| D191 | Chlorpropamide | small molecule | DB00672 | Details | |||
| D192 | Losartan | small molecule | DB00678 | Details | |||
| D193 | Thioridazine | small molecule | DB00679 | Details | |||
| D194 | Warfarin | small molecule | DB00682 | Details | |||
| D195 | Midazolam | small molecule | DB00683 | Details | |||
| D196 | Tobramycin | small molecule | DB00684 | Details | |||
| D197 | Fludrocortisone | small molecule | DB00687 | Details | |||
| D198 | Phentolamine | small molecule | DB00692 | Details | |||
| D199 | Furosemide | small molecule | DB00695 | Details | |||
| D200 | Eplerenone | small molecule | DB00700 | Details | |||
| D201 | Amprenavir | small molecule | DB00701 | Details | |||
| D202 | Naltrexone | small molecule | DB00704 | Details | |||
| D203 | Tamsulosin | small molecule | DB00706 | Details | |||
| D204 | Lamivudine | small molecule | DB00709 | Details | |||
| D205 | Ibandronate | small molecule | DB00710 | Details | |||
| D206 | Flurbiprofen | small molecule | DB00712 | Details | |||
| D207 | Oxacillin | small molecule | DB00713 | Details | |||
| D208 | Paroxetine | small molecule | DB00715 | Details | |||
| D209 | Lisinopril | small molecule | DB00722 | Details | |||
| D210 | Nitroglycerin | small molecule | DB00727 | Details | |||
| D211 | Rocuronium | small molecule | DB00728 | Details | |||
| D212 | Risperidone | small molecule | DB00734 | Details | |||
| D213 | Esomeprazole | small molecule | DB00736 | Details | |||
| D214 | Pentamidine | small molecule | DB00738 | Details | |||
| D215 | Hydrocortisone | small molecule | DB00741 | Details | |||
| D216 | Mannitol | small molecule | DB00742 | Details | |||
| D217 | Deferoxamine | small molecule | DB00746 | Details | |||
| D218 | Prilocaine | small molecule | DB00750 | Details | |||
| D219 | Isoflurane | small molecule | DB00753 | Details | |||
| D220 | Clopidogrel | small molecule | DB00758 | Details | |||
| D221 | Methimazole | small molecule | DB00763 | Details | |||
| D222 | Clavulanic acid | small molecule | DB00766 | Details | |||
| D223 | Alprostadil | small molecule | DB00770 | Details | |||
| D224 | Mefenamic acid | small molecule | DB00784 | Details | |||
| D225 | Perindopril | small molecule | DB00790 | Details | |||
| D226 | Alfentanil | small molecule | DB00802 | Details | |||
| D227 | Pentoxifylline | small molecule | DB00806 | Details | |||
| D228 | Indapamide | small molecule | DB00808 | Details | |||
| D229 | Tropicamide | small molecule | DB00809 | Details | |||
| D230 | Ribavirin | small molecule | DB00811 | Details | |||
| D231 | Fentanyl | small molecule | DB00813 | Details | |||
| D232 | Propofol | small molecule | DB00818 | Details | |||
| D233 | Acetazolamide | small molecule | DB00819 | Details | |||
| D234 | Tadalafil | small molecule | DB00820 | Details | |||
| D235 | Fosfomycin | small molecule | DB00828 | Details | |||
| D236 | Diazepam | small molecule | DB00829 | Details | |||
| D237 | Trifluoperazine | small molecule | DB00831 | Details | |||
| D238 | Mifepristone | small molecule | DB00834 | Details | |||
| D239 | Tolazamide | small molecule | DB00839 | Details | |||
| D240 | Dobutamine | small molecule | DB00841 | Details | |||
| D241 | Donepezil | small molecule | DB00843 | Details | |||
| D242 | Nalbuphine | small molecule | DB00844 | Details | |||
| D243 | Levamisole | small molecule | DB00848 | Details | |||
| D244 | Perphenazine | small molecule | DB00850 | Details | |||
| D245 | Pseudoephedrine | small molecule | DB00852 | Details | |||
| D246 | Aminolevulinic acid | small molecule | DB00855 | Details | |||
| D247 | Terbinafine | small molecule | DB00857 | Details | |||
| D248 | Prednisolone | small molecule | DB00860 | Details | |||
| D249 | Diflunisal | small molecule | DB00861 | Details | |||
| D250 | Terbutaline | small molecule | DB00871 | Details | |||
| D251 | Guaifenesin | small molecule | DB00874 | Details | |||
| D252 | Eprosartan | small molecule | DB00876 | Details | |||
| D253 | Sirolimus | small molecule | DB00877 | Details | |||
| D254 | Emtricitabine | small molecule | DB00879 | Details | |||
| D255 | Quinapril | small molecule | DB00881 | Details | |||
| D256 | Isosorbide dinitrate | small molecule | DB00883 | Details | |||
| D257 | Mechlorethamine | small molecule | DB00888 | Details | |||
| D258 | Ethanol | small molecule | DB00898 | Details | |||
| D259 | Remifentanil | small molecule | DB00899 | Details | |||
| D260 | Ondansetron | small molecule | DB00904 | Details | |||
| D261 | Cocaine | small molecule | DB00907 | Details | |||
| D262 | Repaglinide | small molecule | DB00912 | Details | |||
| D263 | Phenformin | small molecule | DB00914 | Details | |||
| D264 | Amantadine | small molecule | DB00915 | Details | |||
| D265 | Metronidazole | small molecule | DB00916 | Details | |||
| D266 | Dinoprostone | small molecule | DB00917 | Details | |||
| D267 | Buprenorphine | small molecule | DB00921 | Details | |||
| D268 | Azacitidine | small molecule | DB00928 | Details | |||
| D269 | Misoprostol | small molecule | DB00929 | Details | |||
| D270 | Mesoridazine | small molecule | DB00933 | Details | |||
| D271 | Oxymetazoline | small molecule | DB00935 | Details | |||
| D272 | Salicylic acid | small molecule | DB00936 | Details | |||
| D273 | Acetylsalicylic acid | small molecule | DB00945 | Details | |||
| D274 | Phenprocoumon | small molecule | DB00946 | Details | |||
| D275 | Fexofenadine | small molecule | DB00950 | Details | |||
| D276 | Isoniazid | small molecule | DB00951 | Details | |||
| D277 | Norgestimate | small molecule | DB00957 | Details | |||
| D278 | Methylprednisolone | small molecule | DB00959 | Details | |||
| D279 | Mepivacaine | small molecule | DB00961 | Details | |||
| D280 | Zaleplon | small molecule | DB00962 | Details | |||
| D281 | Bromfenac | small molecule | DB00963 | Details | |||
| D282 | Telmisartan | small molecule | DB00966 | Details | |||
| D283 | Methyldopa | small molecule | DB00968 | Details | |||
| D284 | Ezetimibe | small molecule | DB00973 | Details | |||
| D285 | Edetic acid | small molecule | DB00974 | Details | |||
| D286 | Dipyridamole | small molecule | DB00975 | Details | |||
| D287 | Ethinylestradiol | small molecule | DB00977 | Details | |||
| D288 | Physostigmine | small molecule | DB00981 | Details | |||
| D289 | Isotretinoin | small molecule | DB00982 | Details | |||
| D290 | Nandrolone phenpropionate | small molecule | DB00984 | Details | |||
| D291 | Glycopyrronium | small molecule | DB00986 | Details | |||
| D292 | Dopamine | small molecule | DB00988 | Details | |||
| D293 | Azathioprine | small molecule | DB00993 | Details | |||
| D294 | Gabapentin | small molecule | DB00996 | Details | |||
| D295 | Frovatriptan | small molecule | DB00998 | Details | |||
| D296 | Hydrochlorothiazide | small molecule | DB00999 | Details | |||
| D297 | Salbutamol | small molecule | DB01001 | Details | |||
| D298 | Levobupivacaine | small molecule | DB01002 | Details | |||
| D299 | Hydroxyurea | small molecule | DB01005 | Details | |||
| D300 | Letrozole | small molecule | DB01006 | Details | |||
| D301 | Metyrapone | small molecule | DB01011 | Details | |||
| D302 | Cinacalcet | small molecule | DB01012 | Details | |||
| D303 | Sulfamethoxazole | small molecule | DB01015 | Details | |||
| D304 | Bethanechol | small molecule | DB01019 | Details | |||
| D305 | Phylloquinone | small molecule | DB01022 | Details | |||
| D306 | Felodipine | small molecule | DB01023 | Details | |||
| D307 | Mycophenolic acid | small molecule | DB01024 | Details | |||
| D308 | Amlexanox | small molecule | DB01025 | Details | |||
| D309 | Irbesartan | small molecule | DB01029 | Details | |||
| D310 | Probenecid | small molecule | DB01032 | Details | |||
| D311 | Fenofibrate | small molecule | DB01039 | Details | |||
| D312 | Thalidomide | small molecule | DB01041 | Details | |||
| D313 | Ibuprofen | small molecule | DB01050 | Details | |||
| D314 | Benzylpenicillin | small molecule | DB01053 | Details | |||
| D315 | Amoxicillin | small molecule | DB01060 | Details | |||
| D316 | Melatonin | small molecule | DB01065 | Details | |||
| D317 | Glipizide | small molecule | DB01067 | Details | |||
| D318 | Promethazine | small molecule | DB01069 | Details | |||
| D319 | Diphenhydramine | small molecule | DB01075 | Details | |||
| D320 | Atorvastatin | small molecule | DB01076 | Details | |||
| D321 | Vigabatrin | small molecule | DB01080 | Details | |||
| D322 | Streptomycin | small molecule | DB01082 | Details | |||
| D323 | Orlistat | small molecule | DB01083 | Details | |||
| D324 | Pilocarpine | small molecule | DB01085 | Details | |||
| D325 | Benzocaine | small molecule | DB01086 | Details | |||
| D326 | Dimethyl sulfoxide | small molecule | DB01093 | Details | |||
| D327 | Pimozide | small molecule | DB01100 | Details | |||
| D328 | Sertraline | small molecule | DB01104 | Details | |||
| D329 | Miconazole | small molecule | DB01110 | Details | |||
| D330 | Nifedipine | small molecule | DB01115 | Details | |||
| D331 | Amiodarone | small molecule | DB01118 | Details | |||
| D332 | Diazoxide | small molecule | DB01119 | Details | |||
| D333 | Gliclazide | small molecule | DB01120 | Details | |||
| D334 | Tolbutamide | small molecule | DB01124 | Details | |||
| D335 | Dutasteride | small molecule | DB01126 | Details | |||
| D336 | Pioglitazone | small molecule | DB01132 | Details | |||
| D337 | Carvedilol | small molecule | DB01136 | Details | |||
| D338 | Levofloxacin | small molecule | DB01137 | Details | |||
| D339 | Cefadroxil | small molecule | DB01140 | Details | |||
| D340 | Bupropion | small molecule | DB01156 | Details | |||
| D341 | Terazosin | small molecule | DB01162 | Details | |||
| D342 | Ofloxacin | small molecule | DB01165 | Details | |||
| D343 | Cilostazol | small molecule | DB01166 | Details | |||
| D344 | Itraconazole | small molecule | DB01167 | Details | |||
| D345 | Chlormezanone | small molecule | DB01178 | Details | |||
| D346 | Naloxone | small molecule | DB01183 | Details | |||
| D347 | Domperidone | small molecule | DB01184 | Details | |||
| D348 | Ciclopirox | small molecule | DB01188 | Details | |||
| D349 | Desflurane | small molecule | DB01189 | Details | |||
| D350 | Clindamycin | small molecule | DB01190 | Details | |||
| D351 | Dexfenfluramine | small molecule | DB01191 | Details | |||
| D352 | Captopril | small molecule | DB01197 | Details | |||
| D353 | Zopiclone | small molecule | DB01198 | Details | |||
| D354 | Bromocriptine | small molecule | DB01200 | Details | |||
| D355 | Clarithromycin | small molecule | DB01211 | Details | |||
| D356 | Ceftriaxone | small molecule | DB01212 | Details | |||
| D357 | Anastrozole | small molecule | DB01217 | Details | |||
| D358 | Dantrolene | small molecule | DB01219 | Details | |||
| D359 | Budesonide | small molecule | DB01222 | Details | |||
| D360 | Quetiapine | small molecule | DB01224 | Details | |||
| D361 | Paclitaxel | small molecule | DB01229 | Details | |||
| D362 | Metoclopramide | small molecule | DB01233 | Details | |||
| D363 | Dexamethasone | small molecule | DB01234 | Details | |||
| D364 | Sevoflurane | small molecule | DB01236 | Details | |||
| D365 | Aripiprazole | small molecule | DB01238 | Details | |||
| D366 | Epoprostenol | small molecule | DB01240 | Details | |||
| D367 | Gliquidone | small molecule | DB01251 | Details | |||
| D368 | Dasatinib | small molecule | DB01254 | Details | |||
| D369 | Lapatinib | small molecule | DB01259 | Details | |||
| D370 | Darunavir | small molecule | DB01264 | Details | |||
| D371 | Sunitinib | small molecule | DB01268 | Details | |||
| D372 | Hydralazine | small molecule | DB01275 | Details | |||
| D373 | Lumiracoxib | small molecule | DB01283 | Details | |||
| D374 | Glucosamine | small molecule | DB01296 | Details | |||
| D375 | Cefazolin | small molecule | DB01327 | Details | |||
| D376 | Vecuronium | small molecule | DB01339 | Details | |||
| D377 | Cilazapril | small molecule | DB01340 | Details | |||
| D378 | Spirapril | small molecule | DB01348 | Details | |||
| D379 | Ephedrine | small molecule | DB01364 | Details | |||
| D380 | Yohimbine | small molecule | DB01392 | Details | |||
| D381 | Bezafibrate | small molecule | DB01393 | Details | |||
| D382 | Colchicine | small molecule | DB01394 | Details | |||
| D383 | Drospirenone | small molecule | DB01395 | Details | |||
| D384 | Methotrimeprazine | small molecule | DB01403 | Details | |||
| D385 | Clenbuterol | small molecule | DB01407 | Details | |||
| D386 | Theobromine | small molecule | DB01412 | Details | |||
| D387 | Cefepime | small molecule | DB01413 | Details | |||
| D388 | Alfacalcidol | small molecule | DB01436 | Details | |||
| D389 | Diamorphine | small molecule | DB01452 | Details | |||
| D390 | Metamfetamine | small molecule | DB01577 | Details | |||
| D391 | Sulfamethazine | small molecule | DB01582 | Details | |||
| D392 | Ursodeoxycholic acid | small molecule | DB01586 | Details | |||
| D393 | Probucol | small molecule | DB01599 | Details | |||
| D394 | Lopinavir | small molecule | DB01601 | Details | |||
| D395 | Tazobactam | small molecule | DB01606 | Details | |||
| D396 | Hydroxychloroquine | small molecule | DB01611 | Details | |||
| D397 | Molindone | small molecule | DB01618 | Details | |||
| D398 | Thiothixene | small molecule | DB01623 | Details | |||
| D399 | Sorbitol | small molecule | DB01638 | Details | |||
| D400 | Genistein | small molecule | DB01645 | Details | |||
| D401 | N,N-dimethylarginine | small molecule | DB01686 | Details | |||
| D402 | Prasterone | small molecule | DB01708 | Details | |||
| D403 | Pantothenic acid | small molecule | DB01783 | Details | |||
| D404 | Taurine | small molecule | DB01956 | Details | |||
| D405 | Calcipotriol | small molecule | DB02300 | Details | |||
| D406 | Thymol | small molecule | DB02513 | Details | |||
| D407 | gamma-Aminobutyric acid | small molecule | DB02530 | Details | |||
| D408 | Terlipressin | small molecule | DB02638 | Details | |||
| D409 | Nicotinamide | small molecule | DB02701 | Details | |||
| D410 | Fusidic acid | small molecule | DB02703 | Details | |||
| D411 | Resveratrol | small molecule | DB02709 | Details | |||
| D412 | Oxitriptan | small molecule | DB02959 | Details | |||
| D413 | Glycolic acid | small molecule | DB03085 | Details | |||
| D414 | Acetylcholine | small molecule | DB03128 | Details | |||
| D415 | Acetic acid | small molecule | DB03166 | Details | |||
| D416 | Phenol | small molecule | DB03255 | Details | |||
| D417 | Palmitic Acid | small molecule | DB03796 | Details | |||
| D418 | Eucalyptol | small molecule | DB03852 | Details | |||
| D419 | Citric acid | small molecule | DB04272 | Details | |||
| D420 | Maleic Acid | small molecule | DB04299 | Details | |||
| D421 | N,N,N-trimethylglycinium | small molecule | DB04455 | Details | |||
| D422 | Meso-Erythritol | small molecule | DB04481 | Details | |||
| D423 | Indole | small molecule | DB04532 | Details | |||
| D424 | Arachidonic Acid | small molecule | DB04557 | Details | |||
| D425 | Buformin | small molecule | DB04830 | Details | |||
| D426 | Methaqualone | small molecule | DB04833 | Details | |||
| D427 | Cyproterone acetate | small molecule | DB04839 | Details | |||
| D428 | Fluspirilene | small molecule | DB04842 | Details | |||
| D429 | Tetrabenazine | small molecule | DB04844 | Details | |||
| D430 | Febuxostat | small molecule | DB04854 | Details | |||
| D431 | Nebivolol | small molecule | DB04861 | Details | |||
| D432 | Vildagliptin | small molecule | DB04876 | Details | |||
| D433 | Voglibose | small molecule | DB04878 | Details | |||
| D434 | Iloperidone | small molecule | DB04946 | Details | |||
| D435 | Lobeline | small molecule | DB05137 | Details | |||
| D436 | Histamine | small molecule | DB05381 | Details | |||
| D437 | Iodine | small molecule | DB05382 | Details | |||
| D438 | Levoketoconazole | small molecule | DB05667 | Details | |||
| D439 | Acetylcysteine | small molecule | DB06151 | Details | |||
| D440 | Atrasentan | small molecule | DB06199 | Details | |||
| D441 | Rivaroxaban | small molecule | DB06228 | Details | |||
| D442 | Eflornithine | small molecule | DB06243 | Details | |||
| D443 | Sitaxentan | small molecule | DB06268 | Details | |||
| D444 | Amisulpride | small molecule | DB06288 | Details | |||
| D445 | Dapagliflozin | small molecule | DB06292 | Details | |||
| D446 | Darapladib | small molecule | DB06311 | Details | |||
| D447 | Saxagliptin | small molecule | DB06335 | Details | |||
| D448 | Ambrisentan | small molecule | DB06403 | Details | |||
| D449 | Etravirine | small molecule | DB06414 | Details | |||
| D450 | Prucalopride | small molecule | DB06480 | Details | |||
| D451 | Cetilistat | small molecule | DB06586 | Details | |||
| D452 | Agomelatine | small molecule | DB06594 | Details | |||
| D453 | Apixaban | small molecule | DB06605 | Details | |||
| D454 | Bosutinib | small molecule | DB06616 | Details | |||
| D455 | Desvenlafaxine | small molecule | DB06700 | Details | |||
| D456 | Methyltestosterone | small molecule | DB06710 | Details | |||
| D457 | Beta carotene | small molecule | DB06755 | Details | |||
| D458 | Manganese | small molecule | DB06757 | Details | |||
| D459 | Capsaicin | small molecule | DB06774 | Details | |||
| D460 | Chenodeoxycholic acid | small molecule | DB06777 | Details | |||
| D461 | Cupric sulfate | small molecule | DB06778 | Details | |||
| D462 | Lanreotide | small molecule | DB06791 | Details | |||
| D463 | Plerixafor | small molecule | DB06809 | Details | |||
| D464 | Phenylbutyric acid | small molecule | DB06819 | Details | |||
| D465 | 4,4'-PROPANE-2,2-DIYLDIPHENOL | small molecule | DB06973 | Details | |||
| D466 | Emodin | small molecule | DB07715 | Details | |||
| D467 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | small molecule | DB07919 | Details | |||
| D468 | Parecoxib | small molecule | DB08439 | Details | |||
| D469 | Triclosan | small molecule | DB08604 | Details | |||
| D470 | Nandrolone decanoate | small molecule | DB08804 | Details | |||
| D471 | Ticagrelor | small molecule | DB08816 | Details | |||
| D472 | Deferiprone | small molecule | DB08826 | Details | |||
| D473 | Uric acid | small molecule | DB08844 | Details | |||
| D474 | Pitavastatin | small molecule | DB08860 | Details | |||
| D475 | Rilpivirine | small molecule | DB08864 | Details | |||
| D476 | Linaclotide | small molecule | DB08890 | Details | |||
| D477 | Tofacitinib | small molecule | DB08895 | Details | |||
| D478 | Dimethyl fumarate | small molecule | DB08908 | Details | |||
| D479 | Sofosbuvir | small molecule | DB08934 | Details | |||
| D480 | Dexetimide | small molecule | DB08997 | Details | |||
| D481 | Bisacodyl | small molecule | DB09020 | Details | |||
| D482 | Aliskiren | small molecule | DB09026 | Details | |||
| D483 | Ledipasvir | small molecule | DB09027 | Details | |||
| D484 | Acipimox | small molecule | DB09055 | Details | |||
| D485 | Ciprofibrate | small molecule | DB09064 | Details | |||
| D486 | Olaparib | small molecule | DB09074 | Details | |||
| D487 | Benzoyl peroxide | small molecule | DB09096 | Details | |||
| D488 | Coenzyme M | small molecule | DB09110 | Details | |||
| D489 | Nicorandil | small molecule | DB09220 | Details | |||
| D490 | Manidipine | small molecule | DB09238 | Details | |||
| D491 | Methylene blue | small molecule | DB09241 | Details | |||
| D492 | Moxonidine | small molecule | DB09242 | Details | |||
| D493 | Ubidecarenone | small molecule | DB09270 | Details | |||
| D494 | Silibinin | small molecule | DB09298 | Details | |||
| D495 | Glycerin | small molecule | DB09462 | Details | |||
| D496 | Methyl salicylate | small molecule | DB09543 | Details | |||
| D497 | Ixazomib | small molecule | DB09570 | Details | |||
| D498 | Hydrogen peroxide | small molecule | DB11091 | Details | |||
| D499 | Lycopene | small molecule | DB11231 | Details | |||
| D500 | Medetomidine | small molecule | DB11428 | Details | |||
| D501 | Lesinurad | small molecule | DB11560 | Details | |||
| D502 | Carbon monoxide | small molecule | DB11588 | Details | |||
| D503 | Curcumin | small molecule | DB11672 | Details | |||
| D504 | Pyridoxamine | small molecule | DB11673 | Details | |||
| D505 | Equol | small molecule | DB11674 | Details | |||
| D506 | Mosapride | small molecule | DB11675 | Details | |||
| D507 | Ebastine | small molecule | DB11742 | Details | |||
| D508 | Rifamycin | small molecule | DB11753 | Details | |||
| D509 | Imidapril | small molecule | DB11783 | Details | |||
| D510 | Angiotensin II | small molecule | DB11842 | Details | |||
| D511 | Verinurad | small molecule | DB11873 | Details | |||
| D512 | 2,4-thiazolidinedione | small molecule | DB11898 | Details | |||
| D513 | Zuretinol acetate | small molecule | DB12112 | Details | |||
| D514 | Bradykinin | small molecule | DB12126 | Details | |||
| D515 | Sarpogrelate | small molecule | DB12163 | Details | |||
| D516 | Secoisolariciresinol | small molecule | DB12179 | Details | |||
| D517 | Bexagliflozin | small molecule | DB12236 | Details | |||
| D518 | Benzbromarone | small molecule | DB12319 | Details | |||
| D519 | Nitroaspirin | small molecule | DB12445 | Details | |||
| D520 | Piperine | small molecule | DB12582 | Details | |||
| D521 | Isoquercetin | small molecule | DB12665 | Details | |||
| D522 | Cicletanine | small molecule | DB12766 | Details | |||
| D523 | Gallopamil | small molecule | DB12923 | Details | |||
| D524 | Lactitol | small molecule | DB12942 | Details | |||
| D525 | Daidzein | small molecule | DB13182 | Details | |||
| D526 | Camostat | small molecule | DB13729 | Details | |||
| D527 | Fenofibric acid | small molecule | DB13873 | Details | |||
| D528 | Candesartan | small molecule | DB13919 | Details | |||
| D529 | Testosterone enanthate | small molecule | DB13944 | Details | |||
| D530 | Ferric cation | small molecule | DB13949 | Details | |||
| D531 | Palmidrol | small molecule | DB14043 | Details | |||
| D532 | Cianidanol | small molecule | DB14086 | Details | |||
| D533 | Tenofovir | small molecule | DB14126 | Details | |||
| D534 | Cinnamaldehyde | small molecule | DB14184 | Details | |||
| D535 | Cobaltous cation | small molecule | DB14205 | Details | |||
| D536 | Chromic cation | small molecule | DB14525 | Details | |||
| D537 | Zinc cation | small molecule | DB14532 | Details | |||
| D538 | Cupric cation | small molecule | DB14552 | Details | |||
| D539 | Bismuth cation | small molecule | DB14572 | Details | |||
| D540 | Calcium cation | small molecule | DB14577 | Details | |||
| D541 | Cortisone | small molecule | DB14681 | Details | |||
| D542 | Dabigatran | small molecule | DB14726 | Details | |||
| D543 | Remdesivir | small molecule | DB14761 | Details | |||
| D544 | Venglustat | small molecule | DB14966 | Details | |||
| D545 | Abrocitinib | small molecule | DB14973 | Details | |||
| D546 | Ursolic acid | small molecule | DB15588 | Details |