Research Article Details
| Article ID: | A00132 |
| PMID: | 20360734 |
| Source: | Nature |
| Title: | Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. |
| Abstract: | Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed approximately 19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated approximately 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases. |
| DOI: | 10.1038/nature08979 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 1184 | nephrotic syndrome | "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." [url:https\://en.wikipedia.org/wiki/Nephrotic_syndrome, url:https\://www.niddk.nih.gov/health-information/kidney-disease/nephrotic-syndrome-adults] | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D001 | Leuprolide | small molecule | DB00007 | Details | |||
| D002 | Goserelin | small molecule | DB00014 | Details | |||
| D003 | Cetrorelix | small molecule | DB00050 | Details | |||
| D004 | Pyridoxal phosphate | small molecule | DB00114 | Details | |||
| D005 | Histidine | small molecule | DB00117 | Details | |||
| D006 | Phenylalanine | small molecule | DB00120 | Details | |||
| D007 | Biotin | small molecule | DB00121 | Details | |||
| D008 | Choline | small molecule | DB00122 | Details | |||
| D009 | L-Lysine | small molecule | DB00123 | Details | |||
| D010 | Arginine | small molecule | DB00125 | Details | |||
| D011 | Ascorbic acid | small molecule | DB00126 | Details | |||
| D012 | Aspartic acid | small molecule | DB00128 | Details | |||
| D013 | Ornithine | small molecule | DB00129 | Details | |||
| D014 | L-Glutamine | small molecule | DB00130 | Details | |||
| D015 | Serine | small molecule | DB00133 | Details | |||
| D016 | Methionine | small molecule | DB00134 | Details | |||
| D017 | Tyrosine | small molecule | DB00135 | Details | |||
| D018 | Calcitriol | small molecule | DB00136 | Details | |||
| D019 | Lutein | small molecule | DB00137 | Details | |||
| D020 | Riboflavin | small molecule | DB00140 | Details | |||
| D021 | Glutamic acid | small molecule | DB00142 | Details | |||
| D022 | Phosphatidyl serine | small molecule | DB00144 | Details | |||
| D023 | Glycine | small molecule | DB00145 | Details | |||
| D024 | Calcifediol | small molecule | DB00146 | Details | |||
| D025 | Pyridoxal | small molecule | DB00147 | Details | |||
| D026 | Creatine | small molecule | DB00148 | Details | |||
| D027 | Leucine | small molecule | DB00149 | Details | |||
| D028 | Tryptophan | small molecule | DB00150 | Details | |||
| D029 | Cysteine | small molecule | DB00151 | Details | |||
| D030 | Thiamine | small molecule | DB00152 | Details | |||
| D031 | Ergocalciferol | small molecule | DB00153 | Details | |||
| D032 | Threonine | small molecule | DB00156 | Details | |||
| D033 | Alanine | small molecule | DB00160 | Details | |||
| D034 | Valine | small molecule | DB00161 | Details | |||
| D035 | Vitamin A | small molecule | DB00162 | Details | |||
| D036 | Vitamin E | small molecule | DB00163 | Details | |||
| D037 | Pyridoxine | small molecule | DB00165 | Details | |||
| D038 | Isoleucine | small molecule | DB00167 | Details | |||
| D039 | Cholecalciferol | small molecule | DB00169 | Details | |||
| D040 | Menadione | small molecule | DB00170 | Details | |||
| D041 | Proline | small molecule | DB00172 | Details | |||
| D042 | Pravastatin | small molecule | DB00175 | Details | |||
| D043 | Valsartan | small molecule | DB00177 | Details | |||
| D044 | Ramipril | small molecule | DB00178 | Details | |||
| D045 | Esmolol | small molecule | DB00187 | Details | |||
| D046 | Bortezomib | small molecule | DB00188 | Details | |||
| D047 | Phentermine | small molecule | DB00191 | Details | |||
| D048 | Tramadol | small molecule | DB00193 | Details | |||
| D049 | Fluconazole | small molecule | DB00196 | Details | |||
| D050 | Troglitazone | small molecule | DB00197 | Details | |||
| D051 | Oseltamivir | small molecule | DB00198 | Details | |||
| D052 | Erythromycin | small molecule | DB00199 | Details | |||
| D053 | Caffeine | small molecule | DB00201 | Details | |||
| D054 | Reserpine | small molecule | DB00206 | Details | |||
| D055 | Azithromycin | small molecule | DB00207 | Details | |||
| D056 | Pantoprazole | small molecule | DB00213 | Details | |||
| D057 | Torasemide | small molecule | DB00214 | Details | |||
| D058 | Citalopram | small molecule | DB00215 | Details | |||
| D059 | Moxifloxacin | small molecule | DB00218 | Details | |||
| D060 | Indinavir | small molecule | DB00224 | Details | |||
| D061 | Lovastatin | small molecule | DB00227 | Details | |||
| D062 | Pregabalin | small molecule | DB00230 | Details | |||
| D063 | Nevirapine | small molecule | DB00238 | Details | |||
| D064 | Ranolazine | small molecule | DB00243 | Details | |||
| D065 | Ziprasidone | small molecule | DB00246 | Details | |||
| D066 | Doxycycline | small molecule | DB00254 | Details | |||
| D067 | Clotrimazole | small molecule | DB00257 | Details | |||
| D068 | Metoprolol | small molecule | DB00264 | Details | |||
| D069 | Ropinirole | small molecule | DB00268 | Details | |||
| D070 | Chlorotrianisene | small molecule | DB00269 | Details | |||
| D071 | Topiramate | small molecule | DB00273 | Details | |||
| D072 | Olmesartan | small molecule | DB00275 | Details | |||
| D073 | Theophylline | small molecule | DB00277 | Details | |||
| D074 | Lidocaine | small molecule | DB00281 | Details | |||
| D075 | Pamidronic acid | small molecule | DB00282 | Details | |||
| D076 | Chlorambucil | small molecule | DB00291 | Details | |||
| D077 | Morphine | small molecule | DB00295 | Details | |||
| D078 | Bupivacaine | small molecule | DB00297 | Details | |||
| D079 | Tranexamic acid | small molecule | DB00302 | Details | |||
| D080 | Ertapenem | small molecule | DB00303 | Details | |||
| D081 | Mitomycin | small molecule | DB00305 | Details | |||
| D082 | Chlorthalidone | small molecule | DB00310 | Details | |||
| D083 | Valproic acid | small molecule | DB00313 | Details | |||
| D084 | Acetaminophen | small molecule | DB00316 | Details | |||
| D085 | Piperacillin | small molecule | DB00319 | Details | |||
| D086 | Amitriptyline | small molecule | DB00321 | Details | |||
| D087 | Nitroprusside | small molecule | DB00325 | Details | |||
| D088 | Indomethacin | small molecule | DB00328 | Details | |||
| D089 | Metformin | small molecule | DB00331 | Details | |||
| D090 | Methadone | small molecule | DB00333 | Details | |||
| D091 | Olanzapine | small molecule | DB00334 | Details | |||
| D092 | Atenolol | small molecule | DB00335 | Details | |||
| D093 | Cetirizine | small molecule | DB00341 | Details | |||
| D094 | Diltiazem | small molecule | DB00343 | Details | |||
| D095 | Minoxidil | small molecule | DB00350 | Details | |||
| D096 | Chlorzoxazone | small molecule | DB00356 | Details | |||
| D097 | Clozapine | small molecule | DB00363 | Details | |||
| D098 | Levonorgestrel | small molecule | DB00367 | Details | |||
| D099 | Norepinephrine | small molecule | DB00368 | Details | |||
| D100 | Cidofovir | small molecule | DB00369 | Details | |||
| D101 | Mirtazapine | small molecule | DB00370 | Details | |||
| D102 | Treprostinil | small molecule | DB00374 | Details | |||
| D103 | Dydrogesterone | small molecule | DB00378 | Details | |||
| D104 | Amlodipine | small molecule | DB00381 | Details | |||
| D105 | Triamterene | small molecule | DB00384 | Details | |||
| D106 | Phenylephrine | small molecule | DB00388 | Details | |||
| D107 | Digoxin | small molecule | DB00390 | Details | |||
| D108 | Nimodipine | small molecule | DB00393 | Details | |||
| D109 | Progesterone | small molecule | DB00396 | Details | |||
| D110 | Sorafenib | small molecule | DB00398 | Details | |||
| D111 | Zoledronic acid | small molecule | DB00399 | Details | |||
| D112 | Eszopiclone | small molecule | DB00402 | Details | |||
| D113 | Alprazolam | small molecule | DB00404 | Details | |||
| D114 | Loxapine | small molecule | DB00408 | Details | |||
| D115 | Mupirocin | small molecule | DB00410 | Details | |||
| D116 | Rosiglitazone | small molecule | DB00412 | Details | |||
| D117 | Acetohexamide | small molecule | DB00414 | Details | |||
| D118 | Ampicillin | small molecule | DB00415 | Details | |||
| D119 | Spironolactone | small molecule | DB00421 | Details | |||
| D120 | Methocarbamol | small molecule | DB00423 | Details | |||
| D121 | Zolpidem | small molecule | DB00425 | Details | |||
| D122 | Nitric Oxide | small molecule | DB00435 | Details | |||
| D123 | Ceftazidime | small molecule | DB00438 | Details | |||
| D124 | Trimethoprim | small molecule | DB00440 | Details | |||
| D125 | Betamethasone | small molecule | DB00443 | Details | |||
| D126 | Lansoprazole | small molecule | DB00448 | Details | |||
| D127 | Loratadine | small molecule | DB00455 | Details | |||
| D128 | Imipramine | small molecule | DB00458 | Details | |||
| D129 | Dronabinol | small molecule | DB00470 | Details | |||
| D130 | Montelukast | small molecule | DB00471 | Details | |||
| D131 | Fluoxetine | small molecule | DB00472 | Details | |||
| D132 | Duloxetine | small molecule | DB00476 | Details | |||
| D133 | Chlorpromazine | small molecule | DB00477 | Details | |||
| D134 | Amikacin | small molecule | DB00479 | Details | |||
| D135 | Lenalidomide | small molecule | DB00480 | Details | |||
| D136 | Celecoxib | small molecule | DB00482 | Details | |||
| D137 | Altretamine | small molecule | DB00488 | Details | |||
| D138 | Miglitol | small molecule | DB00491 | Details | |||
| D139 | Cefotaxime | small molecule | DB00493 | Details | |||
| D140 | Zidovudine | small molecule | DB00495 | Details | |||
| D141 | Oxycodone | small molecule | DB00497 | Details | |||
| D142 | Cimetidine | small molecule | DB00501 | Details | |||
| D143 | Ritonavir | small molecule | DB00503 | Details | |||
| D144 | Nitazoxanide | small molecule | DB00507 | Details | |||
| D145 | Vancomycin | small molecule | DB00512 | Details | |||
| D146 | Aminocaproic acid | small molecule | DB00513 | Details | |||
| D147 | Trandolapril | small molecule | DB00519 | Details | |||
| D148 | Metolazone | small molecule | DB00524 | Details | |||
| D149 | Tolnaftate | small molecule | DB00525 | Details | |||
| D150 | Lercanidipine | small molecule | DB00528 | Details | |||
| D151 | Cyclophosphamide | small molecule | DB00531 | Details | |||
| D152 | Ciprofloxacin | small molecule | DB00537 | Details | |||
| D153 | Benazepril | small molecule | DB00542 | Details | |||
| D154 | Propylthiouracil | small molecule | DB00550 | Details | |||
| D155 | Zanamivir | small molecule | DB00558 | Details | |||
| D156 | Bosentan | small molecule | DB00559 | Details | |||
| D157 | Methotrexate | small molecule | DB00563 | Details | |||
| D158 | Cisatracurium | small molecule | DB00565 | Details | |||
| D159 | Cephalexin | small molecule | DB00567 | Details | |||
| D160 | Propranolol | small molecule | DB00571 | Details | |||
| D161 | Atropine | small molecule | DB00572 | Details | |||
| D162 | Clonidine | small molecule | DB00575 | Details | |||
| D163 | Lactulose | small molecule | DB00581 | Details | |||
| D164 | Voriconazole | small molecule | DB00582 | Details | |||
| D165 | Diclofenac | small molecule | DB00586 | Details | |||
| D166 | Doxazosin | small molecule | DB00590 | Details | |||
| D167 | Amiloride | small molecule | DB00594 | Details | |||
| D168 | Labetalol | small molecule | DB00598 | Details | |||
| D169 | Thiopental | small molecule | DB00599 | Details | |||
| D170 | Linezolid | small molecule | DB00601 | Details | |||
| D171 | Cisapride | small molecule | DB00604 | Details | |||
| D172 | Nafcillin | small molecule | DB00607 | Details | |||
| D173 | Chloroquine | small molecule | DB00608 | Details | |||
| D174 | Bisoprolol | small molecule | DB00612 | Details | |||
| D175 | Fluphenazine | small molecule | DB00623 | Details | |||
| D176 | Testosterone | small molecule | DB00624 | Details | |||
| D177 | Efavirenz | small molecule | DB00625 | Details | |||
| D178 | Bacitracin | small molecule | DB00626 | Details | |||
| D179 | Niacin | small molecule | DB00627 | Details | |||
| D180 | Alendronic acid | small molecule | DB00630 | Details | |||
| D181 | Prednisone | small molecule | DB00635 | Details | |||
| D182 | Inulin | small molecule | DB00638 | Details | |||
| D183 | Adenosine | small molecule | DB00640 | Details | |||
| D184 | Simvastatin | small molecule | DB00641 | Details | |||
| D185 | Stavudine | small molecule | DB00649 | Details | |||
| D186 | Trazodone | small molecule | DB00656 | Details | |||
| D187 | Verapamil | small molecule | DB00661 | Details | |||
| D188 | Epinephrine | small molecule | DB00668 | Details | |||
| D189 | Pirenzepine | small molecule | DB00670 | Details | |||
| D190 | Cefixime | small molecule | DB00671 | Details | |||
| D191 | Chlorpropamide | small molecule | DB00672 | Details | |||
| D192 | Losartan | small molecule | DB00678 | Details | |||
| D193 | Thioridazine | small molecule | DB00679 | Details | |||
| D194 | Warfarin | small molecule | DB00682 | Details | |||
| D195 | Midazolam | small molecule | DB00683 | Details | |||
| D196 | Tobramycin | small molecule | DB00684 | Details | |||
| D197 | Fludrocortisone | small molecule | DB00687 | Details | |||
| D198 | Phentolamine | small molecule | DB00692 | Details | |||
| D199 | Furosemide | small molecule | DB00695 | Details | |||
| D200 | Eplerenone | small molecule | DB00700 | Details | |||
| D201 | Amprenavir | small molecule | DB00701 | Details | |||
| D202 | Naltrexone | small molecule | DB00704 | Details | |||
| D203 | Tamsulosin | small molecule | DB00706 | Details | |||
| D204 | Lamivudine | small molecule | DB00709 | Details | |||
| D205 | Ibandronate | small molecule | DB00710 | Details | |||
| D206 | Flurbiprofen | small molecule | DB00712 | Details | |||
| D207 | Oxacillin | small molecule | DB00713 | Details | |||
| D208 | Paroxetine | small molecule | DB00715 | Details | |||
| D209 | Lisinopril | small molecule | DB00722 | Details | |||
| D210 | Nitroglycerin | small molecule | DB00727 | Details | |||
| D211 | Rocuronium | small molecule | DB00728 | Details | |||
| D212 | Risperidone | small molecule | DB00734 | Details | |||
| D213 | Esomeprazole | small molecule | DB00736 | Details | |||
| D214 | Pentamidine | small molecule | DB00738 | Details | |||
| D215 | Hydrocortisone | small molecule | DB00741 | Details | |||
| D216 | Mannitol | small molecule | DB00742 | Details | |||
| D217 | Deferoxamine | small molecule | DB00746 | Details | |||
| D218 | Prilocaine | small molecule | DB00750 | Details | |||
| D219 | Isoflurane | small molecule | DB00753 | Details | |||
| D220 | Clopidogrel | small molecule | DB00758 | Details | |||
| D221 | Methimazole | small molecule | DB00763 | Details | |||
| D222 | Clavulanic acid | small molecule | DB00766 | Details | |||
| D223 | Alprostadil | small molecule | DB00770 | Details | |||
| D224 | Mefenamic acid | small molecule | DB00784 | Details | |||
| D225 | Perindopril | small molecule | DB00790 | Details | |||
| D226 | Alfentanil | small molecule | DB00802 | Details | |||
| D227 | Pentoxifylline | small molecule | DB00806 | Details | |||
| D228 | Indapamide | small molecule | DB00808 | Details | |||
| D229 | Tropicamide | small molecule | DB00809 | Details | |||
| D230 | Ribavirin | small molecule | DB00811 | Details | |||
| D231 | Fentanyl | small molecule | DB00813 | Details | |||
| D232 | Propofol | small molecule | DB00818 | Details | |||
| D233 | Acetazolamide | small molecule | DB00819 | Details | |||
| D234 | Tadalafil | small molecule | DB00820 | Details | |||
| D235 | Fosfomycin | small molecule | DB00828 | Details | |||
| D236 | Diazepam | small molecule | DB00829 | Details | |||
| D237 | Trifluoperazine | small molecule | DB00831 | Details | |||
| D238 | Mifepristone | small molecule | DB00834 | Details | |||
| D239 | Tolazamide | small molecule | DB00839 | Details | |||
| D240 | Dobutamine | small molecule | DB00841 | Details | |||
| D241 | Donepezil | small molecule | DB00843 | Details | |||
| D242 | Nalbuphine | small molecule | DB00844 | Details | |||
| D243 | Levamisole | small molecule | DB00848 | Details | |||
| D244 | Perphenazine | small molecule | DB00850 | Details | |||
| D245 | Pseudoephedrine | small molecule | DB00852 | Details | |||
| D246 | Aminolevulinic acid | small molecule | DB00855 | Details | |||
| D247 | Terbinafine | small molecule | DB00857 | Details | |||
| D248 | Prednisolone | small molecule | DB00860 | Details | |||
| D249 | Diflunisal | small molecule | DB00861 | Details | |||
| D250 | Terbutaline | small molecule | DB00871 | Details | |||
| D251 | Guaifenesin | small molecule | DB00874 | Details | |||
| D252 | Eprosartan | small molecule | DB00876 | Details | |||
| D253 | Sirolimus | small molecule | DB00877 | Details | |||
| D254 | Emtricitabine | small molecule | DB00879 | Details | |||
| D255 | Quinapril | small molecule | DB00881 | Details | |||
| D256 | Isosorbide dinitrate | small molecule | DB00883 | Details | |||
| D257 | Mechlorethamine | small molecule | DB00888 | Details | |||
| D258 | Ethanol | small molecule | DB00898 | Details | |||
| D259 | Remifentanil | small molecule | DB00899 | Details | |||
| D260 | Ondansetron | small molecule | DB00904 | Details | |||
| D261 | Cocaine | small molecule | DB00907 | Details | |||
| D262 | Repaglinide | small molecule | DB00912 | Details | |||
| D263 | Phenformin | small molecule | DB00914 | Details | |||
| D264 | Amantadine | small molecule | DB00915 | Details | |||
| D265 | Metronidazole | small molecule | DB00916 | Details | |||
| D266 | Dinoprostone | small molecule | DB00917 | Details | |||
| D267 | Buprenorphine | small molecule | DB00921 | Details | |||
| D268 | Azacitidine | small molecule | DB00928 | Details | |||
| D269 | Misoprostol | small molecule | DB00929 | Details | |||
| D270 | Mesoridazine | small molecule | DB00933 | Details | |||
| D271 | Oxymetazoline | small molecule | DB00935 | Details | |||
| D272 | Salicylic acid | small molecule | DB00936 | Details | |||
| D273 | Acetylsalicylic acid | small molecule | DB00945 | Details | |||
| D274 | Phenprocoumon | small molecule | DB00946 | Details | |||
| D275 | Fexofenadine | small molecule | DB00950 | Details | |||
| D276 | Isoniazid | small molecule | DB00951 | Details | |||
| D277 | Norgestimate | small molecule | DB00957 | Details | |||
| D278 | Methylprednisolone | small molecule | DB00959 | Details | |||
| D279 | Mepivacaine | small molecule | DB00961 | Details | |||
| D280 | Zaleplon | small molecule | DB00962 | Details | |||
| D281 | Bromfenac | small molecule | DB00963 | Details | |||
| D282 | Telmisartan | small molecule | DB00966 | Details | |||
| D283 | Methyldopa | small molecule | DB00968 | Details | |||
| D284 | Ezetimibe | small molecule | DB00973 | Details | |||
| D285 | Edetic acid | small molecule | DB00974 | Details | |||
| D286 | Dipyridamole | small molecule | DB00975 | Details | |||
| D287 | Ethinylestradiol | small molecule | DB00977 | Details | |||
| D288 | Physostigmine | small molecule | DB00981 | Details | |||
| D289 | Isotretinoin | small molecule | DB00982 | Details | |||
| D290 | Nandrolone phenpropionate | small molecule | DB00984 | Details | |||
| D291 | Glycopyrronium | small molecule | DB00986 | Details | |||
| D292 | Dopamine | small molecule | DB00988 | Details | |||
| D293 | Azathioprine | small molecule | DB00993 | Details | |||
| D294 | Gabapentin | small molecule | DB00996 | Details | |||
| D295 | Frovatriptan | small molecule | DB00998 | Details | |||
| D296 | Hydrochlorothiazide | small molecule | DB00999 | Details | |||
| D297 | Salbutamol | small molecule | DB01001 | Details | |||
| D298 | Levobupivacaine | small molecule | DB01002 | Details | |||
| D299 | Hydroxyurea | small molecule | DB01005 | Details | |||
| D300 | Letrozole | small molecule | DB01006 | Details | |||
| D301 | Metyrapone | small molecule | DB01011 | Details | |||
| D302 | Cinacalcet | small molecule | DB01012 | Details | |||
| D303 | Sulfamethoxazole | small molecule | DB01015 | Details | |||
| D304 | Bethanechol | small molecule | DB01019 | Details | |||
| D305 | Phylloquinone | small molecule | DB01022 | Details | |||
| D306 | Felodipine | small molecule | DB01023 | Details | |||
| D307 | Mycophenolic acid | small molecule | DB01024 | Details | |||
| D308 | Amlexanox | small molecule | DB01025 | Details | |||
| D309 | Irbesartan | small molecule | DB01029 | Details | |||
| D310 | Probenecid | small molecule | DB01032 | Details | |||
| D311 | Fenofibrate | small molecule | DB01039 | Details | |||
| D312 | Thalidomide | small molecule | DB01041 | Details | |||
| D313 | Ibuprofen | small molecule | DB01050 | Details | |||
| D314 | Benzylpenicillin | small molecule | DB01053 | Details | |||
| D315 | Amoxicillin | small molecule | DB01060 | Details | |||
| D316 | Melatonin | small molecule | DB01065 | Details | |||
| D317 | Glipizide | small molecule | DB01067 | Details | |||
| D318 | Promethazine | small molecule | DB01069 | Details | |||
| D319 | Diphenhydramine | small molecule | DB01075 | Details | |||
| D320 | Atorvastatin | small molecule | DB01076 | Details | |||
| D321 | Vigabatrin | small molecule | DB01080 | Details | |||
| D322 | Streptomycin | small molecule | DB01082 | Details | |||
| D323 | Orlistat | small molecule | DB01083 | Details | |||
| D324 | Pilocarpine | small molecule | DB01085 | Details | |||
| D325 | Benzocaine | small molecule | DB01086 | Details | |||
| D326 | Dimethyl sulfoxide | small molecule | DB01093 | Details | |||
| D327 | Pimozide | small molecule | DB01100 | Details | |||
| D328 | Sertraline | small molecule | DB01104 | Details | |||
| D329 | Miconazole | small molecule | DB01110 | Details | |||
| D330 | Nifedipine | small molecule | DB01115 | Details | |||
| D331 | Amiodarone | small molecule | DB01118 | Details | |||
| D332 | Diazoxide | small molecule | DB01119 | Details | |||
| D333 | Gliclazide | small molecule | DB01120 | Details | |||
| D334 | Tolbutamide | small molecule | DB01124 | Details | |||
| D335 | Dutasteride | small molecule | DB01126 | Details | |||
| D336 | Pioglitazone | small molecule | DB01132 | Details | |||
| D337 | Carvedilol | small molecule | DB01136 | Details | |||
| D338 | Levofloxacin | small molecule | DB01137 | Details | |||
| D339 | Cefadroxil | small molecule | DB01140 | Details | |||
| D340 | Bupropion | small molecule | DB01156 | Details | |||
| D341 | Terazosin | small molecule | DB01162 | Details | |||
| D342 | Ofloxacin | small molecule | DB01165 | Details | |||
| D343 | Cilostazol | small molecule | DB01166 | Details | |||
| D344 | Itraconazole | small molecule | DB01167 | Details | |||
| D345 | Chlormezanone | small molecule | DB01178 | Details | |||
| D346 | Naloxone | small molecule | DB01183 | Details | |||
| D347 | Domperidone | small molecule | DB01184 | Details | |||
| D348 | Ciclopirox | small molecule | DB01188 | Details | |||
| D349 | Desflurane | small molecule | DB01189 | Details | |||
| D350 | Clindamycin | small molecule | DB01190 | Details | |||
| D351 | Dexfenfluramine | small molecule | DB01191 | Details | |||
| D352 | Captopril | small molecule | DB01197 | Details | |||
| D353 | Zopiclone | small molecule | DB01198 | Details | |||
| D354 | Bromocriptine | small molecule | DB01200 | Details | |||
| D355 | Clarithromycin | small molecule | DB01211 | Details | |||
| D356 | Ceftriaxone | small molecule | DB01212 | Details | |||
| D357 | Anastrozole | small molecule | DB01217 | Details | |||
| D358 | Dantrolene | small molecule | DB01219 | Details | |||
| D359 | Budesonide | small molecule | DB01222 | Details | |||
| D360 | Quetiapine | small molecule | DB01224 | Details | |||
| D361 | Paclitaxel | small molecule | DB01229 | Details | |||
| D362 | Metoclopramide | small molecule | DB01233 | Details | |||
| D363 | Dexamethasone | small molecule | DB01234 | Details | |||
| D364 | Sevoflurane | small molecule | DB01236 | Details | |||
| D365 | Aripiprazole | small molecule | DB01238 | Details | |||
| D366 | Epoprostenol | small molecule | DB01240 | Details | |||
| D367 | Gliquidone | small molecule | DB01251 | Details | |||
| D368 | Dasatinib | small molecule | DB01254 | Details | |||
| D369 | Lapatinib | small molecule | DB01259 | Details | |||
| D370 | Darunavir | small molecule | DB01264 | Details | |||
| D371 | Sunitinib | small molecule | DB01268 | Details | |||
| D372 | Hydralazine | small molecule | DB01275 | Details | |||
| D373 | Lumiracoxib | small molecule | DB01283 | Details | |||
| D374 | Glucosamine | small molecule | DB01296 | Details | |||
| D375 | Cefazolin | small molecule | DB01327 | Details | |||
| D376 | Vecuronium | small molecule | DB01339 | Details | |||
| D377 | Cilazapril | small molecule | DB01340 | Details | |||
| D378 | Spirapril | small molecule | DB01348 | Details | |||
| D379 | Ephedrine | small molecule | DB01364 | Details | |||
| D380 | Yohimbine | small molecule | DB01392 | Details | |||
| D381 | Bezafibrate | small molecule | DB01393 | Details | |||
| D382 | Colchicine | small molecule | DB01394 | Details | |||
| D383 | Drospirenone | small molecule | DB01395 | Details | |||
| D384 | Methotrimeprazine | small molecule | DB01403 | Details | |||
| D385 | Clenbuterol | small molecule | DB01407 | Details | |||
| D386 | Theobromine | small molecule | DB01412 | Details | |||
| D387 | Cefepime | small molecule | DB01413 | Details | |||
| D388 | Alfacalcidol | small molecule | DB01436 | Details | |||
| D389 | Diamorphine | small molecule | DB01452 | Details | |||
| D390 | Metamfetamine | small molecule | DB01577 | Details | |||
| D391 | Sulfamethazine | small molecule | DB01582 | Details | |||
| D392 | Ursodeoxycholic acid | small molecule | DB01586 | Details | |||
| D393 | Probucol | small molecule | DB01599 | Details | |||
| D394 | Lopinavir | small molecule | DB01601 | Details | |||
| D395 | Tazobactam | small molecule | DB01606 | Details | |||
| D396 | Hydroxychloroquine | small molecule | DB01611 | Details | |||
| D397 | Molindone | small molecule | DB01618 | Details | |||
| D398 | Thiothixene | small molecule | DB01623 | Details | |||
| D399 | Sorbitol | small molecule | DB01638 | Details | |||
| D400 | Genistein | small molecule | DB01645 | Details | |||
| D401 | N,N-dimethylarginine | small molecule | DB01686 | Details | |||
| D402 | Prasterone | small molecule | DB01708 | Details | |||
| D403 | Pantothenic acid | small molecule | DB01783 | Details | |||
| D404 | Taurine | small molecule | DB01956 | Details | |||
| D405 | Calcipotriol | small molecule | DB02300 | Details | |||
| D406 | Thymol | small molecule | DB02513 | Details | |||
| D407 | gamma-Aminobutyric acid | small molecule | DB02530 | Details | |||
| D408 | Terlipressin | small molecule | DB02638 | Details | |||
| D409 | Nicotinamide | small molecule | DB02701 | Details | |||
| D410 | Fusidic acid | small molecule | DB02703 | Details | |||
| D411 | Resveratrol | small molecule | DB02709 | Details | |||
| D412 | Oxitriptan | small molecule | DB02959 | Details | |||
| D413 | Glycolic acid | small molecule | DB03085 | Details | |||
| D414 | Acetylcholine | small molecule | DB03128 | Details | |||
| D415 | Acetic acid | small molecule | DB03166 | Details | |||
| D416 | Phenol | small molecule | DB03255 | Details | |||
| D417 | Palmitic Acid | small molecule | DB03796 | Details | |||
| D418 | Eucalyptol | small molecule | DB03852 | Details | |||
| D419 | Citric acid | small molecule | DB04272 | Details | |||
| D420 | Maleic Acid | small molecule | DB04299 | Details | |||
| D421 | N,N,N-trimethylglycinium | small molecule | DB04455 | Details | |||
| D422 | Meso-Erythritol | small molecule | DB04481 | Details | |||
| D423 | Indole | small molecule | DB04532 | Details | |||
| D424 | Arachidonic Acid | small molecule | DB04557 | Details | |||
| D425 | Buformin | small molecule | DB04830 | Details | |||
| D426 | Methaqualone | small molecule | DB04833 | Details | |||
| D427 | Cyproterone acetate | small molecule | DB04839 | Details | |||
| D428 | Fluspirilene | small molecule | DB04842 | Details | |||
| D429 | Tetrabenazine | small molecule | DB04844 | Details | |||
| D430 | Febuxostat | small molecule | DB04854 | Details | |||
| D431 | Nebivolol | small molecule | DB04861 | Details | |||
| D432 | Vildagliptin | small molecule | DB04876 | Details | |||
| D433 | Voglibose | small molecule | DB04878 | Details | |||
| D434 | Iloperidone | small molecule | DB04946 | Details | |||
| D435 | Lobeline | small molecule | DB05137 | Details | |||
| D436 | Histamine | small molecule | DB05381 | Details | |||
| D437 | Iodine | small molecule | DB05382 | Details | |||
| D438 | Levoketoconazole | small molecule | DB05667 | Details | |||
| D439 | Acetylcysteine | small molecule | DB06151 | Details | |||
| D440 | Atrasentan | small molecule | DB06199 | Details | |||
| D441 | Rivaroxaban | small molecule | DB06228 | Details | |||
| D442 | Eflornithine | small molecule | DB06243 | Details | |||
| D443 | Sitaxentan | small molecule | DB06268 | Details | |||
| D444 | Amisulpride | small molecule | DB06288 | Details | |||
| D445 | Dapagliflozin | small molecule | DB06292 | Details | |||
| D446 | Darapladib | small molecule | DB06311 | Details | |||
| D447 | Saxagliptin | small molecule | DB06335 | Details | |||
| D448 | Ambrisentan | small molecule | DB06403 | Details | |||
| D449 | Etravirine | small molecule | DB06414 | Details | |||
| D450 | Prucalopride | small molecule | DB06480 | Details | |||
| D451 | Cetilistat | small molecule | DB06586 | Details | |||
| D452 | Agomelatine | small molecule | DB06594 | Details | |||
| D453 | Apixaban | small molecule | DB06605 | Details | |||
| D454 | Bosutinib | small molecule | DB06616 | Details | |||
| D455 | Desvenlafaxine | small molecule | DB06700 | Details | |||
| D456 | Methyltestosterone | small molecule | DB06710 | Details | |||
| D457 | Beta carotene | small molecule | DB06755 | Details | |||
| D458 | Manganese | small molecule | DB06757 | Details | |||
| D459 | Capsaicin | small molecule | DB06774 | Details | |||
| D460 | Chenodeoxycholic acid | small molecule | DB06777 | Details | |||
| D461 | Cupric sulfate | small molecule | DB06778 | Details | |||
| D462 | Lanreotide | small molecule | DB06791 | Details | |||
| D463 | Plerixafor | small molecule | DB06809 | Details | |||
| D464 | Phenylbutyric acid | small molecule | DB06819 | Details | |||
| D465 | 4,4'-PROPANE-2,2-DIYLDIPHENOL | small molecule | DB06973 | Details | |||
| D466 | Emodin | small molecule | DB07715 | Details | |||
| D467 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | small molecule | DB07919 | Details | |||
| D468 | Parecoxib | small molecule | DB08439 | Details | |||
| D469 | Triclosan | small molecule | DB08604 | Details | |||
| D470 | Nandrolone decanoate | small molecule | DB08804 | Details | |||
| D471 | Ticagrelor | small molecule | DB08816 | Details | |||
| D472 | Deferiprone | small molecule | DB08826 | Details | |||
| D473 | Uric acid | small molecule | DB08844 | Details | |||
| D474 | Pitavastatin | small molecule | DB08860 | Details | |||
| D475 | Rilpivirine | small molecule | DB08864 | Details | |||
| D476 | Linaclotide | small molecule | DB08890 | Details | |||
| D477 | Tofacitinib | small molecule | DB08895 | Details | |||
| D478 | Dimethyl fumarate | small molecule | DB08908 | Details | |||
| D479 | Sofosbuvir | small molecule | DB08934 | Details | |||
| D480 | Dexetimide | small molecule | DB08997 | Details | |||
| D481 | Bisacodyl | small molecule | DB09020 | Details | |||
| D482 | Aliskiren | small molecule | DB09026 | Details | |||
| D483 | Ledipasvir | small molecule | DB09027 | Details | |||
| D484 | Acipimox | small molecule | DB09055 | Details | |||
| D485 | Ciprofibrate | small molecule | DB09064 | Details | |||
| D486 | Olaparib | small molecule | DB09074 | Details | |||
| D487 | Benzoyl peroxide | small molecule | DB09096 | Details | |||
| D488 | Coenzyme M | small molecule | DB09110 | Details | |||
| D489 | Nicorandil | small molecule | DB09220 | Details | |||
| D490 | Manidipine | small molecule | DB09238 | Details | |||
| D491 | Methylene blue | small molecule | DB09241 | Details | |||
| D492 | Moxonidine | small molecule | DB09242 | Details | |||
| D493 | Ubidecarenone | small molecule | DB09270 | Details | |||
| D494 | Silibinin | small molecule | DB09298 | Details | |||
| D495 | Glycerin | small molecule | DB09462 | Details | |||
| D496 | Methyl salicylate | small molecule | DB09543 | Details | |||
| D497 | Ixazomib | small molecule | DB09570 | Details | |||
| D498 | Hydrogen peroxide | small molecule | DB11091 | Details | |||
| D499 | Lycopene | small molecule | DB11231 | Details | |||
| D500 | Medetomidine | small molecule | DB11428 | Details | |||
| D501 | Lesinurad | small molecule | DB11560 | Details | |||
| D502 | Carbon monoxide | small molecule | DB11588 | Details | |||
| D503 | Curcumin | small molecule | DB11672 | Details | |||
| D504 | Pyridoxamine | small molecule | DB11673 | Details | |||
| D505 | Equol | small molecule | DB11674 | Details | |||
| D506 | Mosapride | small molecule | DB11675 | Details | |||
| D507 | Ebastine | small molecule | DB11742 | Details | |||
| D508 | Rifamycin | small molecule | DB11753 | Details | |||
| D509 | Imidapril | small molecule | DB11783 | Details | |||
| D510 | Angiotensin II | small molecule | DB11842 | Details | |||
| D511 | Verinurad | small molecule | DB11873 | Details | |||
| D512 | 2,4-thiazolidinedione | small molecule | DB11898 | Details | |||
| D513 | Zuretinol acetate | small molecule | DB12112 | Details | |||
| D514 | Bradykinin | small molecule | DB12126 | Details | |||
| D515 | Sarpogrelate | small molecule | DB12163 | Details | |||
| D516 | Secoisolariciresinol | small molecule | DB12179 | Details | |||
| D517 | Bexagliflozin | small molecule | DB12236 | Details | |||
| D518 | Benzbromarone | small molecule | DB12319 | Details | |||
| D519 | Nitroaspirin | small molecule | DB12445 | Details | |||
| D520 | Piperine | small molecule | DB12582 | Details | |||
| D521 | Isoquercetin | small molecule | DB12665 | Details | |||
| D522 | Cicletanine | small molecule | DB12766 | Details | |||
| D523 | Gallopamil | small molecule | DB12923 | Details | |||
| D524 | Lactitol | small molecule | DB12942 | Details | |||
| D525 | Daidzein | small molecule | DB13182 | Details | |||
| D526 | Camostat | small molecule | DB13729 | Details | |||
| D527 | Fenofibric acid | small molecule | DB13873 | Details | |||
| D528 | Candesartan | small molecule | DB13919 | Details | |||
| D529 | Testosterone enanthate | small molecule | DB13944 | Details | |||
| D530 | Ferric cation | small molecule | DB13949 | Details | |||
| D531 | Palmidrol | small molecule | DB14043 | Details | |||
| D532 | Cianidanol | small molecule | DB14086 | Details | |||
| D533 | Tenofovir | small molecule | DB14126 | Details | |||
| D534 | Cinnamaldehyde | small molecule | DB14184 | Details | |||
| D535 | Cobaltous cation | small molecule | DB14205 | Details | |||
| D536 | Chromic cation | small molecule | DB14525 | Details | |||
| D537 | Zinc cation | small molecule | DB14532 | Details | |||
| D538 | Cupric cation | small molecule | DB14552 | Details | |||
| D539 | Bismuth cation | small molecule | DB14572 | Details | |||
| D540 | Calcium cation | small molecule | DB14577 | Details | |||
| D541 | Cortisone | small molecule | DB14681 | Details | |||
| D542 | Dabigatran | small molecule | DB14726 | Details | |||
| D543 | Remdesivir | small molecule | DB14761 | Details | |||
| D544 | Venglustat | small molecule | DB14966 | Details | |||
| D545 | Abrocitinib | small molecule | DB14973 | Details | |||
| D546 | Ursolic acid | small molecule | DB15588 | Details |