Bioactive Compound Details
| Compound ID: | B675133 |
| Source ID: | CHEMBL1201182 |
| Source Type: | Small molecule |
| Compound Name: | TEMSIROLIMUS |
| Synonyms: | CCI-779|Temsirolimus|Temsirolimus|Temsirolimus|Temsirolimus|Temsirolimus|Temsirolimus|Temsirolimus|Temsirolimus|Temsirolimus|Torisel |
| Molecular Formula: | C56H87NO16 |
| SMILES: | CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C |
| Molecular Species: |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T50 | Interferon-induced helicase C domain-containing protein 1 | IFIH1 | Hydrolase | Q9BYX4 | IFIH1_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T16 | Phospholipase C-gamma-2 | PLCG2 | Hydrolase | P16885 | PLCG2_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T07 | Potassium channel, inwardly rectifying, subfamily J, member 11 | KCNJ11 | OPENER | Target is a single protein chain | Q14654 | KCNJ11_HUMAN | Details |
| T06 | Sulfonylurea receptor 1 | ABCC8 | Target is a single protein chain | Q09428 | ABCC8_HUMAN | Details |