Bioactive Compound Details
| Compound ID: | B453228 |
| Source ID: | CHEMBL507361 |
| Source Type: | Small molecule |
| Compound Name: | MIRDAMETINIB |
| Synonyms: | Mirdametinib|Mirdametinib|Mirdametinib|Pd 0325901|Pd 03525901|Pd 901|Pd-0325901|PD-0325901 |
| Molecular Formula: | C16H14F3IN2O4 |
| SMILES: | O=C(NOC[C@H](O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T50 | Interferon-induced helicase C domain-containing protein 1 | IFIH1 | Hydrolase | Q9BYX4 | IFIH1_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T16 | Phospholipase C-gamma-2 | PLCG2 | Hydrolase | P16885 | PLCG2_HUMAN | Details | |
| T09 | Serine/threonine-protein kinase AKT2 | AKT2 | INHIBITOR | Target is a single protein chain | P31751 | AKT2_HUMAN | Details |
| T30 | TP53-regulating kinase | TP53RK | Target is a single protein chain | Q96S44 | TP53RK_HUMAN | Details | |
| T01 | Insulin receptor | INSR | AGONIST; INHIBITOR | Target is a single protein chain | P06213 | INSR_HUMAN | Details |
| T07 | Potassium channel, inwardly rectifying, subfamily J, member 11 | KCNJ11 | OPENER | Target is a single protein chain | Q14654 | KCNJ11_HUMAN | Details |
| T06 | Sulfonylurea receptor 1 | ABCC8 | Target is a single protein chain | Q09428 | ABCC8_HUMAN | Details |